ID A0A9L0RJH0_HORSE Unreviewed; 1380 AA.
AC A0A9L0RJH0;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 05-FEB-2025, entry version 9.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000064080.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSECAP00000064080.1,
GN ECO:0000313|VGNC:VGNC:56458};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000064080.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000064080.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000064080.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000064080.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000064080.1};
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR Ensembl; ENSECAT00000089193.1; ENSECAP00000064080.1; ENSECAG00000008523.4.
DR VGNC; VGNC:56458; NLRP1.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000002281; Chromosome 11.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR FunFam; 1.10.533.10:FF:000013; Apoptosis-associated speck-like protein containing a CARD; 1.
DR FunFam; 3.40.50.300:FF:000897; NLR family pyrin domain containing 1; 1.
DR FunFam; 3.80.10.10:FF:000256; NLR family pyrin domain containing 1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 31..120
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 260..565
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 984..1267
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1277..1366
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 155403 MW; B70ACFC697F86493 CRC64;
MAAQDLVPGV QAQETEDSEE HRTAPPAQAE MAGGAELQWP WYLESREKKE PKEFQLRLPD
AHSRHSPGET VAQVEASGPE VASRLVALYG QRQAWDLALL TQRRMDLSRV SIQAHREAAS
IPIQVSSLHA SLGKPNLEFS SAPTSTMVLG HWVPEAPGLL QDSQRKNLRH LPGTSGHTWK
GIRERYQKQW RETPCPTQSR QNEDLHQKFV QLLLLHTSDP GSHESLVRRC CPHGVVEEEG
HLIEIGDLFG PGLGTQRGPH TVVLHGVTGI GKSTLARQVR GAWEEGRLYR DRFQHVFYFN
CTELAQSKPV SLAKLMGEDC AAPAPPIRSQ QEKMLFILDG LDEPELVLEE QRPLCEDWSL
RQPVPRVLHS LLRKVLLPEA SLLVTARTPA PQKFILSLEH PHWVEVLGFS ESSRKEYFYR
YFTEESQAVQ AFSLVESNPA LLTLCLVPFV SWMVCTCLKQ QMERGEELSL TSQTTTALCL
HYLSQALPAQ PLRTQLRCLC SLAAEGVGQG ETLFSLNDLR KHRLDGACIS TLLKMGLLQK
HPTSQRYSFI HPFFQGFFAA MSYALGDKEK SDHLNSTRRI KKLLEKCERH DPFGTPTTPF
LFGLLSEQGV RKMEHIFRCK LSQERKGDLL QKVEAEVRRG HPSLPPYSLQ VLRCLYEIQD
EDFLTQAMAH FQRTRMYVQT DMELLVFTFC VKFCHHVERL QLNESGPHRQ AWRPSSVVLL
SRAPVTDACW KVLFSVLQVT GSLKELDLSG NFLSLSAVQS LCEALRHPRC HLQTLRLASC
GLTAEGCKDL ASGLSTSQTL TELELSCNVL EDAGVKHLCQ GLRQPSCVLQ RLLLVSCGLT
SGFCQDLASV LSAGSRLTEL DLQQNKLGDL GVKLLCEGLR RPTCQLMLLW LDQTQLNEEV
TEMLRALEKN AQLLILSRWK PSVTTPNEGR DGGEMSENRC SLKRQRAESE SSSPQVVQVQ
PLFLPFPASP GDPHVEPLET KDDFWGPMGP VATEVVDKER SLYRVHLPMA GSYRWPNTGL
HFVVRGPVTI EIEFCAWGQF LDRTVPQHSW MVVGPLFDIK AEPGAVAAVY LPHFVVLQGA
HVDISLFQVA HFKEEGMLLE KPARVEPCYA VLENPSFSPV GVLLRMIHAA LPFIPVTSTV
LLYYHFQPEE VTFHLYLIPN DCTIRKAIDD EEKKFQFVRI HKPPPLTPLY VGSRYTVSGS
KKLEIIPKEL ELCYRSPGES QLFSEFYIDH FGTGIKLQMR DKKDGTVVWE ALVKRGDLRL
TATPVPPALK VSPSHGLAPA SLHFVDRYRE QLVARVTSVD PVLDKLHGLV LSEEQYEKVR
AEATTPSQMR KLFSFSKSWD WACKDKFYQA LKETHPHLIV ELWEKWGHGG ELGTASKLGS
//