ID   A0A9J7YDV5_CYPCA        Unreviewed;      2132 AA.
AC   A0A9J7YDV5;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   05-FEB-2025, entry version 9.
DE   RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Cyprinus carpio carpio.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=630221 {ECO:0000313|Ensembl:ENSCCRP00000115560.1, ECO:0000313|Proteomes:UP001108240};
RN   [1] {ECO:0000313|Ensembl:ENSCCRP00000115560.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
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DR   Ensembl; ENSCCRT00000177643.1; ENSCCRP00000115560.1; ENSCCRG00000030276.2.
DR   GeneTree; ENSGT00940000159520; -.
DR   Proteomes; UP001108240; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR050637; NLRP_innate_immun_reg.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF19; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF13553; FIIND; 2.
DR   Pfam; PF05729; NACHT; 2.
DR   Pfam; PF17776; NLRC4_HD2; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF52047; RNI-like; 2.
DR   PROSITE; PS51830; FIIND; 2.
DR   PROSITE; PS50837; NACHT; 2.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP001108240}.
FT   DOMAIN          93..226
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          812..1082
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          1201..1403
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          1928..2132
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
SQ   SEQUENCE   2132 AA;  243707 MW;  94409D236A9147E6 CRC64;
     MNLQYRTLLN DRSKFAAMDK LLSDERLDLA ACSTEPVIIQ RSKEQTKKYY GEWVRSVRTF
     GKQTPSPLLL NDENHSIRID QLFSPDSDGN TPKTVILSGD SGRGKSFMLQ KIMLDWASGE
     LYSENFDAVF LLKCEEFKSI STEESLFYLL SLNHSLTSKQ ISKILQLTPE KVLILIDGMD
     EYVSRPRIHF MQHTNLYTKA PVMVILTNLL RRVLLPESFM LVTTRSAVDT VNLLKDPQRF
     TEIMGFSERG VQEYFQKFFQ DEQLFRKMYE RVKINESLLT ACSVPLLCWM VCFCLKKHFT
     DDDHVMRELK TNTSIYVHFV STLLEHHDQS QSVLTMLRSL GQLAEEGMKK QQVFFVGKSV
     TMKCFDAVTT LFLYKDGLKI KDSQKPAFRF MHHSFQEFFT ALYYVLLDEE NSWWKVSELL
     DWMEWGDIID RPSPERRSNP IPSVMLFLCG LLNKKVSSSL FKKIQWTVPH TVKLKEKLQE
     SVLRLTTHSG CELYALHCLY ELQDERFVSE ALKKHNFMDL SNISLTSTDC WVLLYCLQCC
     PHVRYLNLMY CDLTAEKLKI LQPALCMSKT MRLSVEHLSE VADLIQILGE SKILRQLKVQ
     EDENSAESPR WSLNLSITRG DVLLSLSSSE KSPSFPAVLN ITLTCPQSEI SSTDWSLFLQ
     RLSKTGKVAE DSSALDEHVS LLLSSFHSVG LKTLDLKLVS LNESWASGII CLVQTCTSLQ
     QLNVCADLLL EEGIMLLNKS LTDPHCTVII EGSESSKHTD QCKELDCSHS CYDKVKIHFK
     PKVLEQLKKL NISEPEPSVM NLYCQSCVHI GDSDQWVQVE PLACTDEGGS EFRISTPAGR
     FECSRTRMRW VCAGDITLQY RAVDGGFLSE ELERLQCERI GPVIDVTVIS GKLEEAHLPH
     YACLAESYSS LKYAVKVLGI LESVELTCFH AKILQPSFWP TTVIKEKDIP VEQHLDLLIF
     MTSEDPLILH VYFIPLFDTF SKEKIKQEET AYNPHVLEIE HPSPSMKIQM DTPHVLKVSG
     ASVDSKEGIT FLSSIHPVFF KIKQDIDGDV QMTLIKQQHE MFVWKTIIWK DKLNQKKQEM
     RDLMARFGRL STEMRKHKKR KPRKGWSDII LYYKASVIDK CKFVTECNLP TDECVELAGR
     YTEPVIIQRS KEQNEKYYHE HVRSAHASGL NTSSHLLSND KNRSIRIDQL FSPDCDGNTP
     KTVILSGDSG RGKSFTLQKI MLDWAFGKLY YKNFDVIFLL KCEELKCISE EMSLFELLSW
     SCSLTLDQIS QILELTPEKV LILIDGIDEY VSHPPSHSML VLTNPSDRAQ PMDIFRNVLK
     GILLPESFML VTTISLAADA EINLLKGPQR FTEIVGFSER GVQEYFQKFF WDEQLFRKTY
     ERVKINESLL TACSVPLLCW MVCFCLKKHF TDDDHVMREL KTTTSIYVYF VSTLLEHHDQ
     SQSVLTMLRS LGQRAEEGVK KREGLFVEKS VTATGLDPAT NVFLYKDSLK RNNRQVQVFK
     FMHLSFQEFF TALYYVLLDK EESWGKVTDL LTSLKMKGII NRPSPERRSN PIPSVMMFLC
     GLLNEKASNS LFEMIKWTVP QIINLKTNMQ GSLLTVIRHN GCELFALRCL FELQDEKVVR
     RALGDWVSMN LHNVPLRSKD CWVLLYCLQC CPHVRYLNLM YCDSTAEKLK ILQPALCMCE
     NMRLSVKHLS EVGDLIQILG KSKFLKKMRV QESENSAESP RWSLDLSVTH GDVLLSLSSS
     EKNPSFPAVL NITLTCPQSE ISSTDWSLFL QRLSKTEKVA EDSSALDEHV SLLLSLFHSV
     GLKTLNLKLV SLNKSWASGI IFLAQTCTSL QQLSVSVTGL LLEEGLMFLK KSLTEPHCTV
     IIEGRKCSKL TDQCKEQDWS HSCNEKVEIH LKPKVLKKLE EPTISDSEPS GLNLQPLPVC
     QFCVHIGDSD QWVQVEPSVC TDEGGSEFRI STPAGRFECS RTRMRWVCAG DVTLQYRAVD
     GGFLSEELER LQCERIGPVI DVTVISGKLE EAHLPHYACL AESDPSLRQS VKVLNVEDEG
     ISLESVELTR IHGKVLQPSF SPKTVLMKLG IAVKVHCDLL IFMTHKDPII LHVYFLPIDS
     LFEEKIKIVE KSRHQINLSR PETPLQMNKK QS
//