ID   A0A8P4G7X4_DICLA        Unreviewed;       942 AA.
AC   A0A8P4G7X4;
DT   12-OCT-2022, integrated into UniProtKB/TrEMBL.
DT   12-OCT-2022, sequence version 1.
DT   05-FEB-2025, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDLAP00005067812.1};
OS   Dicentrarchus labrax (European seabass) (Morone labrax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Moronidae; Dicentrarchus.
OX   NCBI_TaxID=13489 {ECO:0000313|Ensembl:ENSDLAP00005067812.1, ECO:0000313|Proteomes:UP000694389};
RN   [1] {ECO:0000313|Ensembl:ENSDLAP00005067812.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
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DR   Ensembl; ENSDLAT00005072974.1; ENSDLAP00005067812.1; ENSDLAG00005032191.1.
DR   GeneTree; ENSGT01100000263761; -.
DR   OMA; VWTCEIR; -.
DR   OrthoDB; 8869108at2759; -.
DR   Proteomes; UP000694389; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 5.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   Pfam; PF02758; PYRIN; 5.
DR   SMART; SM01289; PYRIN; 5.
DR   SUPFAM; SSF47986; DEATH domain; 5.
DR   PROSITE; PS50824; DAPIN; 4.
DR   PROSITE; PS50168; DED; 4.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694389}.
FT   DOMAIN          17..112
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          19..108
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          133..222
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          135..218
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          243..341
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          359..448
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          364..444
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          471..557
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          581..860
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   REGION          860..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..873
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   942 AA;  108197 MW;  12B21F79054B91A8 CRC64;
     MEDEKQRSLL TQRVETMASV IELLLETLKD LSDEEFEEFK KVLNQFPFLS PDLLMFVTTD
     MQSLLLKITD LQDTVFSMVQ TFGQKSVEKT KEVLKKMKRT DLVQRLSDSS SGAKKKHSVD
     EHLSALIHKV ATMAAFKELL LETFSDLSYK DLNTYKWLLQ FTLFKRNLPQ LSWEQLWANS
     VNLLVDVMVE KYGQQSVEVT KEVFMDMNRM DLVQRLSETS SGHKEKHSVD EHWPVLTQKV
     ETMASVIELL LETLKDLTYG EVKEFKLVLS HVRFQLFRLG KWSLLETTGY SLRLLETMGL
     QDTVFLLVQT FGQRSVEKTK EVLKKMNMTD LDQRLSDSSS GSEKKPSTDE QRSALIQKVA
     TIAAVKQLLL ETLKDLSNEE LKKFEEFLQL IFSQKDLQMD LRDTADRAEI VDLMVETYGQ
     QSVELTREVF MDLNRTDLVQ RLSKPSSGLK EKPSVDKRRT ALLERVSARA AVRKILFETL
     SGLNMKELME FKFLLQFKYF QKSLPQISKR QMLFAHSAEE LVDLMVENLL KIRQPVEVTK
     EVFMDMNRTD LVQRLSETSS GLKEGPSRSL VLKGCGSSMQ DSSDWTKLEP DVNSTDADEA
     PAYSLQTEAG KFECSVSGLR WFCKEKISFK YQFCSWEEPM ERMESIQYMP AGPLIDITVI
     AGRLDEVYLP HWICIDDNPA ILDKFAVLHI NDSGDVVEKV SEVTQSHVKL SEPVFSPRAV
     LMKIGFPLKI SCNVLIYYKP NTTFLKLHVY LIPHDLALKK RVDKKESSKG YQLIEKPRPD
     KYLKMKQGFK LAADIDTARI CPKEITLRYD SQEPNFYEVV SENPDGDFHL ILSHTNKSDP
     VWTCEIQKDD DLRYQNSPHL QVQETGGQSS LPGSSDKKHT VNEHLSALMQ NATITTDRER
     LWYVLGRLKR KSSKNSSGSC RTGTSWQASH ASKASGWRRE NC
//