ID A0A8I5YT83_PONAB Unreviewed; 1442 AA.
AC A0A8I5YT83;
DT 25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 1.
DT 05-FEB-2025, entry version 16.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSPPYP00000037968.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSPPYP00000037968.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000037968.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000037968.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000037968.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR Ensembl; ENSPPYT00000035060.1; ENSPPYP00000037968.1; ENSPPYG00000007874.2.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR FunFam; 1.10.533.10:FF:000013; Apoptosis-associated speck-like protein containing a CARD; 1.
DR FunFam; 1.10.533.10:FF:000049; NLR family pyrin domain containing 1; 1.
DR FunFam; 3.40.50.300:FF:000897; NLR family pyrin domain containing 1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 328..637
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1048..1333
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1349..1432
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 90..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1442 AA; 162136 MW; CBB2AE61FC7E91BF CRC64;
MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPAQPEKTSG MEVASYLVAQ
YGEQRAWDLA LHTWEQMGLR SLCAQAQEGA GHSPSFPYSP SEPHLGSPSQ PTSTAVLMPW
IHELPAGCTQ GSERRVLRQL PDTSGRRWRE ISSSLLYQAL PSSPDYESPS QESPNAPTST
AVLGSWGSPP QPSLAPREQE APGTQWPLDE MSGIYYAEIR EREREKSEKG RPPWAAAVGT
PPQAHTSLQP HRHPWEPSVR ESLCSTWPWK NEDLNQKFTQ LLLLQRPHPR SQVPLFKGSW
PHYVEENRGH LIEIRDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVKEA WGRGQLYGER
FQHVFYFSCR ELAQSKVVSL AELIGKDWTV TQAPIRQILS MPERLLFILD GVDEPGWVLQ
EPSSELCLHW SQPQQADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG
FSESSRKEYF YKYFTDERQA IRAFRLVKSN KELWALCLVP WVSWLACACL MQQMKRKEKL
TLTSKTTTTL CLHYLSQALQ AQPLGPQLRD LCSLAAEGIW QKKTLFSPDD LRKHGLDGAV
ISTLLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYALENK KGKGKHSNCI IDLEKLLEAY
GTHGLFGAST TRFLLGLLSD EGEREMENIF HCQLSQGRNL MRWVPSLQLL LQPHSLESLH
CLYETRNKTF LTRVMAHFEE MGMCVETDME LLVSTFCIKF SRHVKKLQLI EGRQHRSTWS
PTMVVLFRWA PVTDAYWQIL FSVLKVTRNL KELDLSGNSL SRSAVKSLCK TLRCPRCLLE
TLRLAGCGLI AEDCKDLASG LRANWTLTKL DLSFNVLTDA GAKHLCQRLR QPSCKLQRLQ
LVSCGVTSDC CQDLASVLSA SPILKELDLQ QNNLDDAGVR LLCEGLRHPA CKLIRLGKPS
VMTPIEGLDT GETSNSTSSL KRQRLRSETE PSHIAQADLK RLDWSILLSA GITEGSSPEV
AQVEPLCLPS PASQGDLHTK ALGTDDDFWG PTGPVAAEIV DKEKSLYRVH FPVAGSYRWP
NMGLCFVVRE AVTVEIEFCV WDQFLGEINP QHSWMVAGPL LDIKAEPGAV EAVHLPHFVA
LQGGHVDTSL FQVAHFKEEG MLLEKPARVE LHHIVLENPS FSPLGVLLKM IHNALRFLPV
TSVVLLYHRL HPEEVTFHLY LIPSDCSIRK AIDDLEMKFQ FVRIHKPPPL TPLYMGCRYT
VSGSGSGMLE ILPKELELCY RSPGEDQLFS EFYVGHLGSG IRLQVKDKKD ETLVWEALVK
PGDLMPATAL VPPACIAVPS PLDAPRLLHF VDQYREQLIA RVTSVEVVLD KLHGQVLSQE
QYERVLAEDT RPSQMRKLFS LSQSWDRRCK DRLYQALKET HPHLIMELWE KGSKKGLLPL
SS
//