ID A0A8C8YSN5_PROSS Unreviewed; 1124 AA.
AC A0A8C8YSN5;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 05-FEB-2025, entry version 17.
DE RecName: Full=NLR family pyrin domain containing 1 {ECO:0008006|Google:ProtNLM};
OS Prolemur simus (Greater bamboo lemur) (Hapalemur simus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Lemuridae; Prolemur.
OX NCBI_TaxID=1328070 {ECO:0000313|Ensembl:ENSPSMP00000004749.1, ECO:0000313|Proteomes:UP000694414};
RN [1] {ECO:0000313|Ensembl:ENSPSMP00000004749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR Ensembl; ENSPSMT00000005699.1; ENSPSMP00000004749.1; ENSPSMG00000003563.1.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000694414; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR FunFam; 1.10.533.10:FF:000013; Apoptosis-associated speck-like protein containing a CARD; 1.
DR FunFam; 3.40.50.300:FF:000897; NLR family pyrin domain containing 1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000694414};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 121..430
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 741..1024
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1024..1113
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
SQ SEQUENCE 1124 AA; 126145 MW; AFC42BB34F37F66B CRC64;
LAILVGSEDR WGQGGPDVPE DSVLQMGPKR GPGSFLSPAR FPHQTSLILL SKENPYSTHS
WENEDLYQNF TQLLLLQRPH PRGCESLVRG SWHHDVAENQ GHLIEMRDLF GPGLGAQAEP
RVVILHGAAG IGKSTLARQV RRAWEEGQLY RDCFQHVFYF SCRELAQAKK LSLAELITKA
SGASPAPLGE ILSCPEYLLF ILDGVDEPRW VLEEQSADFC LHWSRQQPVH NLLGSLLGKT
ILPEASLLIT TRTTALQKLI PSLEQPRWVE VLGFSDSGRK EYFYNYFTEE SEAIRAFGLV
ESNRAVWTLC LLPFVSWLVC SSLKQQMEQG EELTLTPRTA TVLCLQLLSE ALPAQPLGPR
LRGLCSLAAE GVWQGKSLFS PDELRKHKLD DSIISTFLQM GVLQKHDTSL SYSFTHLCFQ
EFFAAMSCAL GDTEERGEHP NRIGVVEKLQ EAYKSQDVFG APTTRFLFGL LSEQAGREME
NIFSRRPRPE RRRELLQWSP ICPCKTDFFV CVSGATIAPG SRPETHPLST RQHLSPHTQI
TSLLSLSPSL SFTRAPVTDA SWLVLCSTLE DSGSLKELDL SGNSLSRSAV HSLCDTLSRP
RCHLETLRLV SCGLTSSCCQ DLASVLSASP SLTELDLQQN DLGDLGVRLL CKGLRHPACQ
LTLLGLDQTP QDEELREHLR ALQEEKPQLV ISGIGADHCP AVPEGSSPQV AQKVEPFCLF
SPASPRDLHM EAVPLGTEGD FWGPTGPVAT EVVDRERSLY RVHFPMSGSY HWPNTGLRFV
VRGAVTIEIE FCSWDQFLRG TIPQHSWMVA GPLFDIKAEP GCVAAVYLPH FVDLQGGHVD
ISLFQVAHFK EEGMLLEKAA RVEPHYTVLE NPSFSPMGVL LRMVHAALRF IPVISTVLLY
HHLHREEVTF HLYLIPSDCS IRKAIDDEEK KFQFVRIHKP PPLTSLYMGS RYTVSGSENL
EIIPEELELC YRSPREPQLF SEIYVGHLGS GIRLQLRDKK DGTVVWKALL KPGKTRATSP
SSPDTSALLH FIDWYREELV ARVTSVDPVL DKLHRHVLSE EQYEQVRAEA TRPGQMRKLF
SFSQSWDQTC KDRLYEALQE THPHLIMELW EKWGSKQGLL SPRS
//