ID A0A8C5CMR6_GADMO Unreviewed; 472 AA.
AC A0A8C5CMR6;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2025, sequence version 2.
DT 05-FEB-2025, entry version 16.
DE SubName: Full=Tyrosine hydroxylase 2 {ECO:0000313|Ensembl:ENSGMOP00000060564.1};
GN Name=th2 {ECO:0000313|Ensembl:ENSGMOP00000060564.1};
OS Gadus morhua (Atlantic cod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX NCBI_TaxID=8049 {ECO:0000313|Ensembl:ENSGMOP00000060564.1, ECO:0000313|Proteomes:UP000694546};
RN [1] {ECO:0000313|Ensembl:ENSGMOP00000060564.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR Ensembl; ENSGMOT00000076905.1; ENSGMOP00000060564.1; ENSGMOG00000001233.2.
DR GeneTree; ENSGT00950000182885; -.
DR Proteomes; UP000694546; Chromosome 4.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR FunFam; 1.10.800.10:FF:000002; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR InterPro; IPR021164; Tyrosine_hydroxylase_CS.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF38; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF21417; TH_ACT; 1.
DR Pfam; PF12549; TOH_N; 1.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000694546}.
SQ SEQUENCE 472 AA; 53400 MW; 986E8446193A3EF2 CRC64;
MKTDNAVQSV PFGGRRQSLI EDARKERAGG AGGPPSPGPH GDHPGFETKD ERVVLNVVVA
LSNEKNSGFF KTGKIFETFE AKLLHVESRP ARKGKNSPGP GDLEFFIRCE VHGADLDVFI
NSLRKVADDI RTFPEEKVPW FPRKIKELDR CKLLITKFDP NVDKEHPGFS DPEYRKRRAL
LSDLAFSYKQ GDPLPTVEYT TEEVATWREV YSTLRSIYPS MACRQFLDAL QQLERECGYG
DDRIPQLREV SAFLKEKTGF QLRPAVGLLS ARDFLASLAF RVFQCTQYIR HASTPMHSPE
PDCCHELLGH VPMLADKEFA EFSQEIGLAS LGASDEDIEK LSTLYWFTLE FGLCKQNGAL
KAYGAGLLSS FGELVYALSN EPECRPFEPE QTSVQPYQDQ TYQPVYFVSE SFEDATVKMR
KFSAKINRPF SVRYDPFTCS VEVLDQPEKI QHTLGQMKED LRVLHTALEK LA
//