ID A0A8C7HY60_ONCKI Unreviewed; 1659 AA.
AC A0A8C7HY60;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 05-FEB-2025, entry version 16.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 1b allele 5-like {ECO:0000313|Ensembl:ENSOKIP00005063915.1};
GN Name=LOC109878766 {ECO:0000313|Ensembl:ENSOKIP00005063915.1};
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019 {ECO:0000313|Ensembl:ENSOKIP00005063915.1, ECO:0000313|Proteomes:UP000694557};
RN [1] {ECO:0000313|Ensembl:ENSOKIP00005063915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR Ensembl; ENSOKIT00005067935.1; ENSOKIP00005063915.1; ENSOKIG00005027317.1.
DR GeneTree; ENSGT01130000278267; -.
DR Proteomes; UP000694557; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR FunFam; 3.40.50.300:FF:000210; Si:dkey-16p6.1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR051261; NLR.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000694557};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 213..346
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 896..1092
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1285..1566
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1572..1658
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..12
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1659 AA; 186318 MW; 00CC6F5B524B458D CRC64;
MSLSGEREET TDSKMSLSGE TEEGTTDSKM NLSGEREEET TASKMSLSGE RETTATKMTQ
DTSSKSVQKP RAESPTTSLL SIKSDQPPAF SQEPLADDNK EVESLDSEDV LKITHNLLDR
RSQTLLTVQQ NIKAKLKHKY QHISEGIGHH GNQSLFKDIY TELYITEGGS GGLNNEHEVR
QMEMAYKKQT TQETPIKCND IFKPLPGQDK PIRTVLTKGI AGIGKTVSVQ KVVLDWAEGK
ANQDVHFMFP LPFRDLNLKK DQYSLMQLLS HYFPEMKEIV SIEDGETKTD FILDGLDECR
LPLDFKNNEK CCDVTKPTSV AVLLTNLIEG NLLPSSHLWI TTRPAAANQI PPECVDQVTE
VRGFNDPQKE EYFRKKITDQ KLANEIIKHI TTSRSLQIMC HIPVFCWISA TVLETMLKVA
EKNEVPKTLT QMCSHFMLIQ IIVKNRKYNK TTETNPKELS QSDKEMILKL AKLAFQQLQK
GNLIFYEEDL RECGLDVTEA SEYSALCTEI FKEESGLYQE KIYSFVHLSI QEFLAAVHAL
ESCLDNKENV FSPTSDDEKK ESIQLSDLHR RAVDQALKSE NGHLDLFLRF LLGLSLESNQ
NLLRGLLTQT GSTTQSHKKT VKRIVRYLSD KIKYESSPER IINLFHCLNE LGSNSLVEDM
QTSLRSGTLS ETRLKPDQCS ALAYLLLMSE EVLEEFDLKT YNTSEKGYQR LLPVVKTCKR
ALLAGCKLTY ESCETLTSAL QTPNSPLREL DLSYNDLRGR GIELLCVGLT SPLCNIQTLV
LGQCGLTEGC CSDLASVLSS PNSQLKQLEL RDNDLQDSGV TLLSAGLVDP DCKLHTLGLS
GCLVTEEGCA ALSSALRSNP SHLKELDLSY NHPGDSAGGL LSAALVDPTY KLMKLNVDHG
GECRLKSGLR KYACHLTLDP NTANPNLILS EGNRKVTCVV EKQHYEDHPD RFDYLYQVLC
REGLSGGRYY WEVERDGSMA DIGVVYKGME RKGWEDASWI GGNRESRCLL CSHSGYRFYH
DGVNRIIPGP VSNRVGVYLD WSAGTLSFYS VSSSGSLTHL YTEHTTFTEP LYPGFGISFF
SVTSVTLRQI DYQHTQRDHG GESWIRPGPE DTRDHGGESW IKPGPEDTRD HGGESCIKPG
PENTRDHGGE SWIKPGPEDT RDHGGESWIK PGPEDTRDHS GECWIKPGPE NTRDHGGESW
IKPGPEDTRD HGGESWTKPG PEDTRDHGGE SWTKPGPEDT RDHGGESWIK PGPENTREHG
GESCIKSGPE KRIPQSCKTC DHVEDSTHWL QIEPLTSTVQ GVTMFRHRTP KGSYECTVSG
LRWLCERDVI LKYHFRNWEP YSQLLKDMQY TQGGPLLDIT MELGELKEVH LPHFVCLGTN
PSLRNEMKIL HVEEHGVSLE EVHEVTRFHA KILHPKFSAI AVILSYIFSW IVDVHCDVVL
YMAVKKSTLI SRLYLLLRNS SQKEAVRERE KDQVSQGYSE FLLSSPNGPL KMNTWFALKN
PHSTSIYPEK IQLLPANTTP SCCKMIMGNT GVDIEMELIG DDERTVWKSV VSKDEYSKDS
HPTPLTLSGI PAEEFLKKHR AELIQGVKNP MPIADDLSSK SMIGDEEYSR ITAETTEQER
MRKLLNAVLP KGPEVMGACL KALREHEQHL VKYLSESST
//