ID A0A8C7AWP1_NEOVI Unreviewed; 428 AA.
AC A0A8C7AWP1;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 05-FEB-2025, entry version 16.
DE RecName: Full=Caspase recruitment domain-containing protein 8 {ECO:0008006|Google:ProtNLM};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|Ensembl:ENSNVIP00000014991.1, ECO:0000313|Proteomes:UP000694425};
RN [1] {ECO:0000313|Ensembl:ENSNVIP00000014991.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR Ensembl; ENSNVIT00000017485.1; ENSNVIP00000014991.1; ENSNVIG00000011703.1.
DR GeneTree; ENSGT00830000128447; -.
DR Proteomes; UP000694425; Unplaced.
DR GO; GO:0072559; C:NLRP3 inflammasome complex; IEA:TreeGrafter.
DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IEA:TreeGrafter.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:TreeGrafter.
DR CDD; cd01671; CARD; 1.
DR FunFam; 1.10.533.10:FF:000090; Caspase recruitment domain family member 8; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR PANTHER; PTHR46985:SF4; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR SMART; SM00114; CARD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000694425}.
FT DOMAIN 39..335
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 342..425
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
SQ SEQUENCE 428 AA; 48983 MW; 983444105839A861 CRC64;
LPNEIPSYLI LDKPIFSEPC LFQKIQSDTY NVYFSEETCL EEETLVPLEA PKLFSGVGPA
CHSYQFLGPE GNVDIELIDE SANRYRKYVL SWVAQSITVR LWLRSVSYTH LDVYKRQMVA
GPLFDISVEP EGVIAEIHLP HIISLPANEV DMSWFHVAHF KDEGMVLEPP ARVESFYAVL
ENPSFSLMGI LLRLASGARV SVPITSTALL YYHFYPKDTK FHLYLIPSDS LLTKAIDEEE
TKFHGVRLQT SPPMEPLNFG SRYIVSGSAH LEIMPEELKL SYRSPGEIQV FSKVFAGKME
EPIILEVTDK RHKTLVWRTL VKPVELQFCA ASPPSPFSAE AFMKENHRHL QARLGDLSGV
LDDLQDSEVF TEEEKELVQQ LPTRQRKNET LLRMVEKKGP QALEIFFRSL QQRDPYLMSY
LSQQNLQQ
//