ID A0A8B7BAH8_ORYAF Unreviewed; 508 AA.
AC A0A8B7BAH8;
DT 19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2022, sequence version 1.
DT 05-FEB-2025, entry version 16.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2-like {ECO:0000313|RefSeq:XP_007956547.1};
GN Name=LOC103212375 {ECO:0000313|RefSeq:XP_007956547.1};
OS Orycteropus afer afer.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Tubulidentata; Orycteropodidae; Orycteropus.
OX NCBI_TaxID=1230840 {ECO:0000313|Proteomes:UP000694850, ECO:0000313|RefSeq:XP_007956547.1};
RN [1] {ECO:0000313|RefSeq:XP_007956547.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_007956547.1; XM_007958356.1.
DR GeneID; 103212375; -.
DR OrthoDB; 2150267at2759; -.
DR Proteomes; UP000694850; Unplaced.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_007956547.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694850};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..324
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 324..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 349..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 334..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_007956547.1"
SQ SEQUENCE 508 AA; 57155 MW; 637E10DCF6E77BAE CRC64;
GQVVFRNGER MGTIKFTQFQ GSEPPKDKTI ILEQLRKISL PLYSILSALT ILGMIMASAF
LFFNIKNRNQ KLIKMSSPYM NNLIILGGML SYASIFLFGL DGSFVSEKTF ETLCTVRTWI
LTVGYTTAFG AMFAKTWRVH AIFKNVKMKK KIIKDQKLLV IVGGMLLIDL CILICWQAVD
PLRRTVERYS MEPDPAGRDI SIRPLLEHCE NTHMTIWLGI VYAYKGLLML FGCFLAWETR
NVSIPALNDS KYIGMSVYNV GIMCIIGAAV SFLTRDQPNV QFCIVALVII FCSTITLCLV
FVPKLITLRT NPDAATQNRR FQFTQNQKKE DSKTSTSVTS VNQASTSRLE GLQSENHRLR
MKITELDKDL EDVTMQLQDT PEKTTYIKQN HYQELNDILN LGNFTESTGQ LESLQILKLK
KSASFLLGDV SRVIARALAG TCKPSLYTRK VAERIQRRLS LQLPILHHAY LPSIGGVDAS
CVSPCVSPTA SPRHRHVPPS FRVMVSGL
//