ID A0A803U0D0_ANOCA Unreviewed; 905 AA.
AC A0A803U0D0;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 05-FEB-2025, entry version 18.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=gabbr2 {ECO:0000313|Ensembl:ENSACAP00000040920.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000040920.1, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000040920.1, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000040920.1,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000040920.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR AlphaFoldDB; A0A803U0D0; -.
DR Ensembl; ENSACAT00000047759.1; ENSACAP00000040920.1; ENSACAG00000002199.4.
DR GeneTree; ENSGT00940000155783; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000002199; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR FunFam; 3.40.50.2300:FF:000072; Gamma-aminobutyric acid type B receptor subunit 2; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 2.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..905
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032771857"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 486..595
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT DOMAIN 608..727
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 722..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 101411 MW; F2651A6479CFBDD9 CRC64;
MPSSASPRRP SPAPPPAWPL LLLLFLLTLA SSSSSSSAWA RSSSRALSGM PPSSSSSSTP
IAIMGLMPLS DAVEKGKIGR GVLPAMQLAM EQILNESLLS PYALDLRYYD TECDNAKGLK
AFYDAIKYGP THLMVFGGVC TTVTSIIAES LIGWNLIQLS FAATTPELAD KKKYPYFFRT
VPSDNAVNPA ILKLLKHFQW KRVGTLTQDI QRFSEVRNDL TGVLYGEEIE ISDTESFSND
PCTSVKKLKG NDVRIIVGQF NEEMAAKVFC CAFNAQMYGP KYQWIIPGWY QTFWWEKAIP
KLNSSNCHTA NILSAMEGYI GVDFEPLSSK QIKTISGRTP QQYEKEYDQR RGNVEPSKFH
GFAYDGIWVI AKTLQQAMKI LNATNKNQKI EDFNYTNKDL GKIFLDAMNQ TSFFGVTGQV
MFRNGERMGT IKFTQFQDKK EVKVGEYNAI LDSLEIINNS IKFQGIEPPK DRTIVQPQLR
KISLPLYSIL SAITILGMIM ASAFLFFNIK NRNQKLIKMS SPYMNNLIIL GGMLSYASIF
LFGLDGSFVS DKTFETLCTV RTWILTVGYT TAFGAMFAKT WRVHAIFKNV KMKKKPDPAG
RDISILPILE HCENSHMTIW LGIVYAYKGL LMLFGCFLAW ETRNVSIPAL NDSKYIGMSV
YNVGIMCIIG AAVSFLTRDQ PNVQFCIVAL VIIFCSTITL CLVFVPKLIT LRTNPDAATR
NRGLQFTQNQ KKDDSKTSTS VTSVNQASTS RLEGLQSENH QLRMKITELD KALEEVTMQL
QDTPEKTTYI KQNHYQELND ILSIRNFTEN KDGEKAVLKN HLDQNPQAQW DTTESSRTNK
DFIEDINSPE HIQRRLSLQL PILHHAYLPS IGGVDASCAS PCVSPSASPR HRHVPPSFRV
MVSGL
//