ID A0A851WGJ5_CORMO Unreviewed; 493 AA.
AC A0A851WGJ5;
DT 29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 1.
DT 05-FEB-2025, entry version 17.
DE RecName: Full=Tyrosine 3-monooxygenase {ECO:0000256|ARBA:ARBA00017181};
DE EC=1.14.16.2 {ECO:0000256|ARBA:ARBA00011993};
DE AltName: Full=Tyrosine 3-hydroxylase {ECO:0000256|ARBA:ARBA00032379};
DE Flags: Fragment;
GN Name=Th_1 {ECO:0000313|EMBL:NXD51952.1};
GN Synonyms=TH {ECO:0000313|Ensembl:ENSCMUP00000024722.1};
GN ORFNames=CORMON_R07201 {ECO:0000313|EMBL:NXD51952.1};
OS Corvus moneduloides (New Caledonian crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Corvoidea; Corvidae; Corvus.
OX NCBI_TaxID=1196302 {ECO:0000313|EMBL:NXD51952.1, ECO:0000313|Proteomes:UP000603793};
RN [1] {ECO:0000313|EMBL:NXD51952.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OUT-0060 {ECO:0000313|EMBL:NXD51952.1};
RC TISSUE=Blood {ECO:0000313|EMBL:NXD51952.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCMUP00000024722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine
CC from L-tyrosine: step 1/2. {ECO:0000256|ARBA:ARBA00004700}.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; WBNF01000125; NXD51952.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A851WGJ5; -.
DR Ensembl; ENSCMUT00000026561.2; ENSCMUP00000024722.1; ENSCMUG00000015073.2.
DR OMA; SVEHGYP; -.
DR OrthoDB; 983542at2759; -.
DR UniPathway; UPA00747; UER00733.
DR Proteomes; UP000603793; Unassembled WGS sequence.
DR Proteomes; UP000694553; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR CDD; cd04930; ACT_TH; 1.
DR CDD; cd03345; eu_TyrOH; 1.
DR FunFam; 1.10.800.10:FF:000002; Tyrosine 3-monooxygenase; 1.
DR FunFam; 3.30.70.260:FF:000024; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR041903; Eu_TyrOH_cat.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR005962; Tyr_3_mOase.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR InterPro; IPR021164; Tyrosine_hydroxylase_CS.
DR NCBIfam; TIGR01269; Tyr_3_monoox; 1.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF21417; TH_ACT; 1.
DR Pfam; PF12549; TOH_N; 2.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Catecholamine biosynthesis {ECO:0000256|ARBA:ARBA00022584};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:NXD51952.1};
KW Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000603793}.
FT DOMAIN 147..493
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 326
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 331
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 371
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXD51952.1"
FT NON_TER 493
FT /evidence="ECO:0000313|EMBL:NXD51952.1"
SQ SEQUENCE 493 AA; 56144 MW; E7D5EF0493D39FD7 CRC64;
MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE AAAAAAATDA
AESTETIVFE EKDGRAMLNL FFMLKGAKTS PLSRVLKVFE TFEAKIHHLE TRLSRKPREG
TAELEYFVRC EVHSSDLNTF ISSIKRVAED VRTTKEDKFH WFPRKICELD KCHHLVTKFD
PDLDLDHPGY SDQVYRQRRK SIAEIAFHYK HGDPIPHVEY TAEETATWKE VYSTLKSLYP
THACKEYLEA FSLLEKFCGY NENNIPQLEE VSRFLKERTG FQLRPVAGLL SARDFLASLA
FRVFQCTQYI RHASSPMHSP EPDCCHELLG HVPMLADKTF AQFSQDIGLA SLGATDEEIE
KLATLYWFTV EFGLCRQNGI VKAYGAGLLS SYGELIHSLS DEPEVRDFDP DAAAVQPYQD
QNYQPVYFVS ESFSDAKNKL RSYAAHIKRP FSVKYEPYTH SIELLDSPQM ICHSLESVRD
ELHSLINALN VIS
//