ID A0A7L3EZR3_9GRUI Unreviewed; 421 AA.
AC A0A7L3EZR3;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 05-FEB-2025, entry version 15.
DE SubName: Full=TY3H monooxygenase {ECO:0000313|EMBL:NXT73497.1};
DE Flags: Fragment;
GN Name=Th_0 {ECO:0000313|EMBL:NXT73497.1};
GN ORFNames=ZAPATR_R08944 {ECO:0000313|EMBL:NXT73497.1};
OS Zapornia atra (Henderson crake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Gruiformes; Rallidae; Zapornia.
OX NCBI_TaxID=2585822 {ECO:0000313|EMBL:NXT73497.1, ECO:0000313|Proteomes:UP000557426};
RN [1] {ECO:0000313|EMBL:NXT73497.1, ECO:0000313|Proteomes:UP000557426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-011-47 {ECO:0000313|EMBL:NXT73497.1};
RC TISSUE=Mixed tissue sample {ECO:0000313|EMBL:NXT73497.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXT73497.1}.
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DR EMBL; VZTU01001306; NXT73497.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L3EZR3; -.
DR Proteomes; UP000557426; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:TreeGrafter.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR FunFam; 1.10.800.10:FF:000002; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF19; BIOPTERIN-DEPENDENT AROMATIC AMINO ACID HYDROXYLASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF21417; TH_ACT; 1.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:NXT73497.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000557426}.
FT DOMAIN 75..421
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 254
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 259
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 299
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXT73497.1"
FT NON_TER 421
FT /evidence="ECO:0000313|EMBL:NXT73497.1"
SQ SEQUENCE 421 AA; 48266 MW; 4AA1E0879B066F1D CRC64;
DGRTTLFLTL TLRNVRNIDL SKAAKVFEIF EIQIHHFETR RAKKPRNSAD DLDIFVECEA
RSADVSILIT SLKRVAEDVK TSREDKVPWF PRKIQDLDKC HHLITNYDPS LDHGHPGYDD
LDYKKRRAFF ADLASNYRVG DPLPHIEYTA QETSTWREVY RKLSSLYPTH ACIQYLDAFH
QLEKYCGYRE DNIPQLQDVS RFLKGQTGFQ LRPAAGLLSA RDFLASLAFR VFQSTQYIRH
FSSPMHSPEP DCCHELLGHV PMLADKEFAQ FSQDIGLASL GSSEAEIEKL ATLYWFTVEF
GLCKQNGSIK AYGAGLLSSY GELTYALSNK PEYKPFDPEV TAVHPYQDQA FQPVYFIAES
LEDAKAKLQN YAMKIKKPFS LLYDPFTSSI EVMNTPQKIK RTLCHMKEEL KSLCLALENL
S
//