ID   A0A7K7TK32_9CHAR        Unreviewed;       352 AA.
AC   A0A7K7TK32;
DT   07-APR-2021, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 1.
DT   05-FEB-2025, entry version 14.
DE   SubName: Full=CARD8 protein {ECO:0000313|EMBL:NXA17255.1};
DE   Flags: Fragment;
GN   Name=Card8 {ECO:0000313|EMBL:NXA17255.1};
GN   ORFNames=IBISTR_R05312 {ECO:0000313|EMBL:NXA17255.1};
OS   Ibidorhyncha struthersii.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Charadriidae;
OC   Ibidorhyncha.
OX   NCBI_TaxID=425643 {ECO:0000313|EMBL:NXA17255.1, ECO:0000313|Proteomes:UP000587655};
RN   [1] {ECO:0000313|EMBL:NXA17255.1, ECO:0000313|Proteomes:UP000587655}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B10K-DU-030-25 {ECO:0000313|EMBL:NXA17255.1};
RA   Zhang G.;
RT   "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:NXA17255.1}.
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DR   EMBL; VZSZ01000432; NXA17255.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A7K7TK32; -.
DR   Proteomes; UP000587655; Unassembled WGS sequence.
DR   GO; GO:0061702; C:canonical inflammasome complex; IEA:TreeGrafter.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF4; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000587655}.
FT   DOMAIN          1..263
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          269..352
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:NXA17255.1"
FT   NON_TER         352
FT                   /evidence="ECO:0000313|EMBL:NXA17255.1"
SQ   SEQUENCE   352 AA;  40219 MW;  BD693439AFDCC293 CRC64;
     RAHFPGTGIF QCPITGLAFK VKSAVTITYK YASWTKHLSK ADQEMWIPAG PLFRIQVQPG
     VVEAVHLPHF ICLAEDVDTS LCSIAHFKSG KMTLERPTRL IPFSAVLENP TFSLLGALWR
     KLRSTLKSLP VHSLVLIFQQ LSAANTTLHL YLIPDDKSVK QAIEKQEMDW NSKIIPKPPP
     FRPLFLGCIY RVTSTNSVEI MPEEQLPFCY KSPKEQQLFF EIYIRNMAEE IGLRMTDTRS
     DTEVWRASLR SGRNSSTVLW ACCLLGVAFL KKHRTNLCSR MGQLSTILLH LRHANVINSD
     EEEEVRGQGT SQRRNQLLLD LVEKKGWEAQ EQLYQILRTK NPYLITDLEK PN
//