ID A0A6P9B8W5_PANGU Unreviewed; 864 AA.
AC A0A6P9B8W5;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 05-FEB-2025, entry version 20.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 isoform X2 {ECO:0000313|RefSeq:XP_034267742.1};
GN Name=GABBR2 {ECO:0000313|RefSeq:XP_034267742.1};
OS Pantherophis guttatus (Corn snake) (Elaphe guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Colubridae; Colubrinae; Pantherophis.
OX NCBI_TaxID=94885 {ECO:0000313|Proteomes:UP000515157, ECO:0000313|RefSeq:XP_034267742.1};
RN [1] {ECO:0000313|RefSeq:XP_034267742.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_034267742.1};
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_034267742.1; XM_034411851.1.
DR AlphaFoldDB; A0A6P9B8W5; -.
DR OrthoDB; 2150267at2759; -.
DR Proteomes; UP000515157; Unplaced.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR FunFam; 3.40.50.2300:FF:000072; Gamma-aminobutyric acid type B receptor subunit 2; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_034267742.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000515157};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 402..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..686
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 681..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97722 MW; D9C6C9B9F073CAD3 CRC64;
MPQLAVCQLE VMQRKAFSVG TLPGGIASEK CDNAKGLKAF YDAIKYGPTH LMVFGGVCTT
VTSIIAESLI GWNLVQLSFA ATTPELADKK KYPYFFRTVP SDNAVNPAIL KLLKHYKWKR
VGTLTQDIRR FSEVRNDLTG VLYGEDIEIS DTESFSNDPC TSVKKLKGND VRIILGQFNE
EMAAKVFCCA FNEKMFGPKY QWIIPGWYQS FWWEKAIPKL NSSHCLGINL LGAMEGYIGV
DFEPLSSKQI KTISGRTPQQ YEEEYDQRRG NVEPSKFHGF AYDGIWVIAK TLQQAMKILN
ATNRNQKIED FNYTNKELGK IFLDAMNQTS FFGVTGQVMF RNGERMGTIK FTQFQDKKEV
KVGEYNAILD SLEIINNSIK FHGKEPPKDR TIIQKQLRKI SLPLYSILSA LTILGMIMAS
AFLFFNIKNR NQKLIKMSSP YMNNLIILGG MLSYASIFLF GLDGSFVSEK TFETLCTIRT
WILTVGYTTA FGAMFAKTWR VHAIFKNVKM KKKIIKDQKL MVIVGGMLLI DLCILICWQV
VDPLRRTVEK YNMEPDPAGR DISILPILEH CENTHMTIWL GIVYAYKGLL MLFGCFLAWE
TRNVSIPALN DSKYIGMSVY NVGIMCIIGA AVSFLTRDQP NVQFCIVALV IIFCSTITLC
LVFVPKLITL RTNPDAATRN RGLQFTQNQK KDDSKTSTSV TSVNQASTSR LEGLQSENHQ
LRMKITELDK ALEEVTMQLQ DTPEKTTYIK QNHYQELNDI LSIRNFTESK DGEKTVLKNH
LDQNPQAQWN TTESSRTSKD FIEDINSPEH IQRRLSLQLP ILHHAYLPSI GGVDASCASP
CVSPSASPRH RHVPPSFRVM VSGL
//