ID A0A6P9APL9_PANGU Unreviewed; 435 AA.
AC A0A6P9APL9;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 05-FEB-2025, entry version 20.
DE SubName: Full=Tyrosine 3-monooxygenase-like {ECO:0000313|RefSeq:XP_034258935.1};
GN Name=LOC117655512 {ECO:0000313|RefSeq:XP_034258935.1};
OS Pantherophis guttatus (Corn snake) (Elaphe guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Colubridae; Colubrinae; Pantherophis.
OX NCBI_TaxID=94885 {ECO:0000313|Proteomes:UP000515157, ECO:0000313|RefSeq:XP_034258935.1};
RN [1] {ECO:0000313|RefSeq:XP_034258935.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_034258935.1};
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR RefSeq; XP_034258935.1; XM_034403044.1.
DR AlphaFoldDB; A0A6P9APL9; -.
DR KEGG; pgut:117655512; -.
DR InParanoid; A0A6P9APL9; -.
DR OMA; QKYALTI; -.
DR Proteomes; UP000515157; Unplaced.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:TreeGrafter.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR FunFam; 1.10.800.10:FF:000002; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF19; BIOPTERIN-DEPENDENT AROMATIC AMINO ACID HYDROXYLASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF21417; TH_ACT; 1.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000515157}.
FT DOMAIN 89..435
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 268
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 273
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 313
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
SQ SEQUENCE 435 AA; 50126 MW; 79C584AAB647C144 CRC64;
MEAQRSRDLA GKREERSATV IFTFALSHKK KSSISKTLRV FEMFEAKIQH FESRTARMSK
NMDGNLELFV RCEVQDCEVS SLLNSLKGVA EDVEAIREEK VPWFPKKIRD LDYCHHLITK
FDPDLNFDHP GYADPEYRKR RAFIADLAFN HRQGDPLPRV EYTAEETATW KEIYQKLNDL
YPTHACKQYL EAFHQLEKYC GYQADCIPQL QDVSAFLKER TGFSLRPAAG LLSPRDFLAA
LAFRVFQSTQ YIRHWSSPMH SPEPDCCHEL LGHVPMLADK DFAQFSQDIG LASLGASDED
IEKLSTFYWF TVEFGLCKQN DSIKAYGAGL LSSYGELIYA LSEKPEYKAF DPDVMVVQPY
HDQTFQPIYF VADCFEDAKS QLQKYALTIK KTFPLHYNPI TCSMEVLDSP QKVSEIATHL
KEELTTLCHV LEKHL
//