ID A0A6P8UE56_GYMAC Unreviewed; 1300 AA.
AC A0A6P8UE56;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 05-FEB-2025, entry version 20.
DE SubName: Full=Protein NLRC3-like isoform X4 {ECO:0000313|RefSeq:XP_034075284.1};
GN Name=LOC117548245 {ECO:0000313|RefSeq:XP_034075284.1};
OS Gymnodraco acuticeps (Antarctic dragonfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Bathydraconidae; Gymnodraco.
OX NCBI_TaxID=8218 {ECO:0000313|Proteomes:UP000515161, ECO:0000313|RefSeq:XP_034075284.1};
RN [1] {ECO:0000313|RefSeq:XP_034075284.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR RefSeq; XP_034075284.1; XM_034219393.1.
DR Proteomes; UP000515161; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR FunFam; 3.40.50.300:FF:001524; Si:dkey-126g1.7; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR051261; NLR.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00114; CARD; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000515161};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 110..152
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 251..385
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 915..1194
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1210..1300
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 147851 MW; 1AE27B25D7434C66 CRC64;
MKLVMKQREE LQTGKDVESE RRKSNCQTPF YTSAEQQEEN RCSVTGFSLR LEKMSDFKVE
EEDKSQFLSG LCGSEQSEEE PPDFRDEPGP SDTKGKRKSP VPVEEQLSSC ALCQDVLKDP
VSTSCGHWFC RQCITSYWEQ RPPSGDSCCP QCGERWNILQ TERGLQEVLD EHRLSLRRRC
ERVTEGTDES ETLLNRIFTE LYITQGQSEE VNTQHEVRQL ETASKKKPLH DTPIKCQDIF
QASPDQQTPI RAVLTNGVAG VGKSFSVQKF TLDWAEGLGN QDVSLVIPLS FRELNLIKGE
QYSLLRLLHV FHPTLQKVTA EQLAVCKVLF IFDGLDESRL SLDFTNNEVV SDVSQQSSVN
VLLTNLIRGK LLSSALVWIT SRPAAANQIP PECVDRVTEV RGFTDAQKEE YFRRRWSDED
LSSRIISHIK SSRSLHIMCL IPVFCWITAA VLDHMLTTDQ RGQLPKTLTD MYAHFLLVQT
KRKKQKYEEG HETSPQQLTE ADRELLLKLG RLAFEHLEKG DIMFYQEDLQ RCGLGVTEAL
VHSGVCTEIF KRESVIFQKT VYCFVHLSIQ EFLAAVYMLH CYTNRDTEVL KDFLQGYYSN
RYNRDQDYPS LDVFLEGAME KSLQSKNGHL DLFVRFLHGL SLESNQRLLG GLLGRTGKRP
TIIERLFRGR LGRTDNRPET IQRAISNLKE MSSYNISPER SINIFHCLTE MKDHSVTQEI
TEFLKSGNRS EELSEIHCSA LAYMLQMSEE VLDELDLRKY NTSDEGRRRL IPAVRNCRKA
ELTDCRLSET DCEVVASALK SNPSHLRDLD LSRNALEDSG VELLSSGLKS PICRLEALRL
ELCSLSEISC SALISALKSN LHLRHLDLSY NNLKDSGVKL RDLLESPDCR LETLRINGET
FRAKIQKTCD SDVEQEVKTD REAPQSFSPE LTTESSYRFR CPGPGEFQCA STGLVFVMAQ
EAELLYRAVP WEESLLQSAG KQAAGPLFDV KSSDEAAVCQ LHLPHSETED ALLLDGLLSV
VHITDEGLSI LEPLEVTRTH VVVKVLHLSP FGLIIDKLKR LLKWRINGQV LVFLRPPGRE
EQILDVFLLH NNVPEEEVVK KHKRAVNIPI SSDCELDIDH SYSVHCEPEG FFIQPESKTF
KSMFGPNYHP TFQVSLMTST ERVFLKVQNQ GGNEVWNYRV SLEDPRKELS QRNVPAESRV
PAESRIPAES RVPAKEWLLS VRTEFIQRVS LSVLKDLLDK LFQSEVINES EMESAKTKSR
NDGAREVVDV VRNKGAAASR VLINALRELD PLLYEELNSS
//