ID A0A6P6H880_PUMCO Unreviewed; 829 AA.
AC A0A6P6H880;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 05-FEB-2025, entry version 21.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|RefSeq:XP_025771862.1};
GN Name=GABBR2 {ECO:0000313|RefSeq:XP_025771862.1};
OS Puma concolor (Mountain lion) (Felis concolor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma.
OX NCBI_TaxID=9696 {ECO:0000313|Proteomes:UP000515131, ECO:0000313|RefSeq:XP_025771862.1};
RN [1] {ECO:0000313|RefSeq:XP_025771862.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025771862.1};
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_025771862.1; XM_025916077.1.
DR AlphaFoldDB; A0A6P6H880; -.
DR KEGG; pcoo:112852537; -.
DR Proteomes; UP000515131; Unplaced.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR FunFam; 3.40.50.2300:FF:000072; Gamma-aminobutyric acid type B receptor subunit 2; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_025771862.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000515131};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 421..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 423..705
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 705..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 94113 MW; 36BC85A28A8E61FD CRC64;
MGLMPLTKEV AKGSIGRGVL PAVELAIEQI RNESLLRPYF LDLRLYDTEC DNAKGLKAFY
DAIKYGPNHL MVFGGVCPSV TSIIAESLQG WNLVQLSFAA TTPVLADKKK YPYFFRTVPS
DNAVNPAILK LLKHYQWKRV GTLTQDVQRF SEVRNDLTGV LYGEDIEISD TESFSNDPCT
SVKKLKGNDV RIILGQFDQN MAAKVFCCAY EENMYGSKYQ WIIPGWYEPS WWEQVHTEAN
SSRCLRKNLL AAMEGYIGVD FEPLSSKQIK TISGKTPQQY EREYNNKRSG VGPSKFHGYA
YDGIWVIAKT LQRAMETLHA SSRHQRIQDF NYTDHTLGRI ILNAMNETNF FGVTGQVVFR
NGERMGTIKF TQFQDSREVK VGEYNAVADT LEIINDTIRF QGSEPPKDKT IILEQLRKIS
LPLYSILSAL TILGMIMASA FLFFNIKNRN QKLIKMSSPY MNNLIILGGM LSYASIFLFG
LDGSFVSEKT FETLCTVRTW ILTVGYTTAF GAMFAKTWRV HAIFKNVKMK KKIIKDQKLL
VIVGGMLLID LCILICWQAV DPLRRTVERY SMEPDPAGRD ISIRPLLEHC ENTHMTIWLG
IVYAYKGLLM LFGCFLAWET RNVSIPALND SKYIGMSVYN VGIMCIIGAA VSFLTRDQPN
VQFCIVALVI IFCSTITLCL VFVPKLITLR TNPDAATQNR RFQFTQNQKK EDSKTSTSVT
SVNQASTSRL EGLQSENHRL RMKITELDKD LEEVTMQLQD TPEKTTYIKQ NHYQELNDIL
NLGNFTESTD GGKAILKNHL DQNPQLQWNT TEPSRTCKDP IEDINSPEQ
//