ID A0A6P6F457_OCTDE Unreviewed; 1299 AA.
AC A0A6P6F457;
DT 02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 1.
DT 05-FEB-2025, entry version 20.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 1-like {ECO:0000313|RefSeq:XP_023579179.1};
GN Name=LOC105743093 {ECO:0000313|RefSeq:XP_023579179.1};
OS Octodon degus (Degu) (Sciurus degus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Octodontidae;
OC Octodon.
OX NCBI_TaxID=10160 {ECO:0000313|Proteomes:UP000515203, ECO:0000313|RefSeq:XP_023579179.1};
RN [1] {ECO:0000313|RefSeq:XP_023579179.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_023579179.1; XM_023723411.1.
DR InParanoid; A0A6P6F457; -.
DR OrthoDB; 428577at2759; -.
DR Proteomes; UP000515203; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:TreeGrafter.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR FunFam; 1.10.533.10:FF:000013; Apoptosis-associated speck-like protein containing a CARD; 1.
DR FunFam; 3.40.50.300:FF:000897; NLR family pyrin domain containing 1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR050637; NLRP_innate_immun_reg.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000515203};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 248..556
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 998..1189
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1205..1288
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 140..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 878..905
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 149359 MW; DF8E0E8AB0958CE2 CRC64;
MDNKLQIVNA CELEQSLLQT SNLGPSSSRM SAIPKNISAS NVTSDLRPPL EVTPVQFSAT
QLNLSDIECM VYPLKRKLKL DKQKLHPLKY NKTDALKGYE KEEEMPCFTH SWKVGNLHQF
SQLILLQKDH PIQPQWHKTI IPDTQKPKPE KSEVEDQSGQ LSKTLCQNIK NDKVDIKHTS
VDLQSYPQHD QKHEKQEQTN KMHKMHDLRG QEVLFKESGF HNSVTKQGHL IEIQDLFSPD
SGTQKEPRTV IVHGPAGIGK SALARQVRRA WQQGWLYRDH FQYVFYINCR KLARYKILSL
AMLMAKDWDK SEVPIGKILS QPEQLLFILD GVDEPKWVLQ DQNAELCWHW SYPLPVSELL
GSLLRKTVLP GASFLITTRT TAIQKFIPFL AQPYWVEILG FSESGKKEYF FKYFTDEKQA
IAAFRLVDSN SALWTLCLVP WVCWLACTCL KQQLEHGNKY PLTCQTTTAL CLHYISQVFP
AQKLSSELRD LCFLAAEGIR KRDTMFSAGD LKKHQLDEAI IFTFLKMGIL QKHSSLTYSF
TQQCFQEFFA AVYFILWNED ERQEHLNCNK YMEELLKRYE SHDLFQAPIL HFLFGLLSTE
GAKEMEHIFS CKLPSQWKWQ LFQWAQEKAP TQPPYSLDFF RCLYETQDEE LLKPAMAHFQ
GTRMCIQTNT ELLVFTFCVK FCNHVKQLQL NDGGHQPQAS WSPEVARSNW LPLTTANWKA
FFAVLQDSRS LKDLDLCGNP LSLCDLQYLC ETLRDTRCYL ETLWLASCSL TAEGCKDLAI
SISTNHRLIN LDLSFNMITD SGARHLCQTL GSPQSKLQRL QLVNCGLTSR CCKNLASLLS
SNPSLMELDL QQNDLSTHGV QQLFEGLRHP NCRLTLLCLD QTFQNEELSK ELNALKEEKH
HLQICSRWNR SVMDSPEDQD GRIIDNSTSS LQQRSQSGTH HIEPLGTEND FQGPMGPVAT
EVVDKERGLY RFYKSPGETQ QELLRIQSMK VWSKAGAETS GGSVDTSLFH VAHFKEEGML
LEKPSRVETH YIVLENPSFS PMGIFLKMFS TARRFIPINC TTLLYHQLQP EDVKFHLYLI
PSDCTIRKAI DDEEKKFQFT RIHKPPPMDS LYIGSCYTVS GSENLEIIPK ELKLHYRSSG
ESQLFSEIYV DNFGSRIQLQ IRNKNDGATV WEALLKPGDL KSAATPVSPA TTASPSSLNV
PSMPHFVDQH KKQLVERVTS VDSVLDKLYG SVLSEEQYES VRAEVTKQNQ MRKLFSFSRS
WDRECKCHFY KVLKETHHHL IMQLWEDWGR KSNTLDSYS
//