ID   A0A6P7JZ79_9TELE        Unreviewed;      1043 AA.
AC   A0A6P7JZ79;
DT   02-DEC-2020, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 1.
DT   05-FEB-2025, entry version 19.
DE   SubName: Full=Uncharacterized protein LOC114448224 isoform X2 {ECO:0000313|RefSeq:XP_028280841.1};
GN   Name=LOC114448224 {ECO:0000313|RefSeq:XP_028280841.1};
OS   Parambassis ranga (Indian glassy fish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Ambassidae; Parambassis.
OX   NCBI_TaxID=210632 {ECO:0000313|Proteomes:UP000515145, ECO:0000313|RefSeq:XP_028280841.1};
RN   [1] {ECO:0000313|RefSeq:XP_028280841.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
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DR   RefSeq; XP_028280841.1; XM_028425040.1.
DR   AlphaFoldDB; A0A6P7JZ79; -.
DR   Proteomes; UP000515145; Chromosome 16.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08321; Pyrin_ASC-like; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 7.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   Pfam; PF02758; PYRIN; 6.
DR   SMART; SM01289; PYRIN; 7.
DR   SUPFAM; SSF47986; DEATH domain; 6.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50168; DED; 1.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000515145}.
FT   DOMAIN          204..287
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          649..928
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          953..1043
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   REGION          385..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          907..942
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          946..973
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        639..660
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1043 AA;  118298 MW;  50A72E3F7A99CD41 CRC64;
     MASERPLVET LNQLSPDDFD RFKSLVEVEK DLPPISKSRL KEGRRQDVVE LLLGTDCVDV
     TRKVLMRMER SVLGQRFPAF QPGDKKTPPP SLRHRVEALV SDTELLLETL ADLTDEDLGT
     FKRTFGLFHR QIPNELMESD LQDSVCLMVQ TYGHQTVEKA AEVLGYMKRK DLALRLTHSG
     STPRRQQLGE HLSAAIHKVA TFKAVTDLLV ETLTGLDRHE VPEFMWLLQY TLFHRSLPQL
     SGRAVNSTDT TLTVDMLVET LGLQSVDVTR EVLSAMRRTD LVQRLPERGS GSREEPSVDE
     DWPALTPKVE ALLSVTEQLV ETLAGLSSRE CWTFKRLLTA THRNIPLKTL LDLDLQASVI
     LMVQRQGLRS LKSTMDVLED MKKSDLVQRH TDSSSNPQRK QQHEHPSALI HKVVTVVAVK
     QLLVEALKHL SYGELGKFKT LLQLTMSEQD LSDVSESVRA TPDRDQIVDL LVDELGQRCV
     KVIRDVFVDM GRTDLVQQLN GPSSESRKRR SMDQCHQALS KAVSAHSSDQ SAAVMMLWSG
     FEQKAERAAV TVTLVEMLSK LDKKGFKKFR WWLHFTLFQR SLRLIPWSSL RVNTRQRLAA
     LMVKKHGLQC VDVTREVLRD INQRPPDSSS GSEGAQRGLE AESCGRGRDA SDWTKVDPEV
     NERADEAPTY SLQTAAGCFE CRVSGLRWLC EGQTSFQYQF CSWEGHMQRM ESRQYMPAGP
     LLDITVTAGR LNEVHLPHWI CTEDNPKILD RFAVLHVKDC GDEVEKVSEV TASHVRLTRP
     MFSPRAVLMK VGLPVKISCS VLLYYKLNTP FLKLHVYLIP HDPALQQTVE KKETSGGYGT
     IRKPRPDRYL KMLQGFVLTA DTDAAKIQPQ KLTLRYDSQD PNFYEVFIES PDRNFTLTLL
     LQSKPSDPVW SSKIRKDDHP HSGPSEAAAS SGEADGVSTL SDEQHCEQLD TQVQETSSDL
     QRLLNLLEEL TQDELKRFKW SLQGPDQRAD RPGIPWGRLE TADRLDLVNL MLQTYGQQQS
     VAVTRSVFRE MSRMDLVQRM SDW
//