ID A0A6J1TZY6_9SAUR Unreviewed; 496 AA.
AC A0A6J1TZY6;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 05-FEB-2025, entry version 20.
DE RecName: Full=Tyrosine 3-monooxygenase {ECO:0000256|ARBA:ARBA00017181};
DE EC=1.14.16.2 {ECO:0000256|ARBA:ARBA00011993};
DE AltName: Full=Tyrosine 3-hydroxylase {ECO:0000256|ARBA:ARBA00032379};
GN Name=TH {ECO:0000313|RefSeq:XP_026524061.1};
OS Notechis scutatus (mainland tiger snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Acanthophiinae; Notechis.
OX NCBI_TaxID=8663 {ECO:0000313|Proteomes:UP000504612, ECO:0000313|RefSeq:XP_026524061.1};
RN [1] {ECO:0000313|RefSeq:XP_026524061.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine
CC from L-tyrosine: step 1/2. {ECO:0000256|ARBA:ARBA00004700}.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR RefSeq; XP_026524061.1; XM_026668276.1.
DR AlphaFoldDB; A0A6J1TZY6; -.
DR UniPathway; UPA00747; UER00733.
DR Proteomes; UP000504612; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR CDD; cd03345; eu_TyrOH; 1.
DR FunFam; 1.10.800.10:FF:000002; Tyrosine 3-monooxygenase; 1.
DR FunFam; 3.30.70.260:FF:000024; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR041903; Eu_TyrOH_cat.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR005962; Tyr_3_mOase.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR InterPro; IPR021164; Tyrosine_hydroxylase_CS.
DR NCBIfam; TIGR01269; Tyr_3_monoox; 1.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF21417; TH_ACT; 1.
DR Pfam; PF12549; TOH_N; 2.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Catecholamine biosynthesis {ECO:0000256|ARBA:ARBA00022584};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000504612}.
FT DOMAIN 150..496
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 329
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 334
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 374
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
SQ SEQUENCE 496 AA; 56588 MW; D20F49BA8A59057D CRC64;
MPTPNTSSSS AKGFRRAVSE LDSKQAEAIM VSKDSPQFIG RRQSLIEDAR KEREAAAAAA
SEAAELTETI VFDEKDGIAL LHLLFTLKGG KTSLPSRALK IFETFEAKIH HLETRPCKKV
REGSPDLEYF VRCELHCSAL NTFISSLKRV SEDVRSTKED KFHWFPRKIS ELDLCHHLVT
KFDPDLDLDH PGFSDQVYRE RRKMIAEIAF HYKHGDPIPR VDYTEEEINT WREVYSTLKS
LYPTHACKEH LDAFHLLERY SGYSENNIPQ LEDVSCFLKE RTGFQLRPVA GLLSARDFLA
SLAFRVFQCT QYIRHASSPM HSPEPDCCHE LLGHVPMLAD KTFAQFSQDI GLASLGATDE
EIEKLSTLYW FTVEFGLCKQ NGIIKAYGAG LLSSYGELIH SLSDEPELRD FDPDMTAMQP
YQDQTYQPVY FVSESFNDAK AKLRVYAAHI KRPFSVKYDP YTYSIELLDH PQKICHSLTN
VRDELHSLID ALNIIS
//