ID A0A6J0AHN2_VICPA Unreviewed; 813 AA.
AC A0A6J0AHN2;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 05-FEB-2025, entry version 21.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 isoform X2 {ECO:0000313|RefSeq:XP_015094451.1};
GN Name=GABBR2 {ECO:0000313|RefSeq:XP_015094451.1};
OS Vicugna pacos (Alpaca) (Lama pacos).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Vicugna.
OX NCBI_TaxID=30538 {ECO:0000313|Proteomes:UP000504605, ECO:0000313|RefSeq:XP_015094451.1};
RN [1] {ECO:0000313|RefSeq:XP_015094451.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_015094451.1};
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_015094451.1; XM_015238965.2.
DR AlphaFoldDB; A0A6J0AHN2; -.
DR GeneID; 102526877; -.
DR CTD; 9568; -.
DR Proteomes; UP000504605; Chromosome 4.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR FunFam; 3.40.50.2300:FF:000063; Gamma-aminobutyric acid type B receptor subunit; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_015094451.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000504605};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 351..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..635
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 635..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 92167 MW; 7BE4898EA0025D6B CRC64;
MVFGGVCPSV TSIIAESLQG WNLVQLSFAA TTPVLADKKK YPYFFRTVPS DNAVNPAILK
LLKHYQWKRV GTLTQDVQRF SEVRNDLTGV LYGEDIEISD TESFSNDPCT SVKKLKGNDV
RIILGQFDQN MAAKVFCCAY EENMYGSKYQ WIIPGWYEPS WWEQVHTEAN SSRCLRKNLL
AAMEGYIGVD FEPLSSKQIK TISGKTPQQY EREYNSKRSG VGPSKFHGYA YDGIWVIAKT
LQRAMETLHA SSRHQRIQDF NYTDHTLGRI ILNAMNETNF FGVTGQVVFR NGERMGTIKF
TQFQDRREVK VGEYNAVADT LEIINDTIRF QGSEPPKDKT IILEQLRKIS LPLYSILSAL
TILGMIMASA FLFFNIKNRN QKLIKMSSPY MNNLIILGGM LSYASIFLFG LDGSFVSEKT
FETLCTVRTW ILTVGYTTAF GAMFAKTWRV HAIFKNVKMK KKIIKDQKLL VIVGGMLLID
LCILICWQAV DPLRRTVERY SMEPDPAGRD ISIRPLLEHC ENTHMTIWLG IVYAYKGLLM
LFGCFLAWET RNVSIPALND SKYIGMSVYN VGIMCIIGAA VSFLTRDQPN VQFCIVALVI
IFCSTITLCL VFVPKLITLR TNPDAATQNR RFQFTQNQKK EDSKTSTSVT SVNQASTSRL
EGLQSENHRL RMKITELDKD LEEVTMQLQD TPEKTTYIKQ NHYQELNDIL NLGNFTESTD
GGKAILKNHL DQNPQLQWNT TEPSRTCKDP IEDINSPEHI QRRLSLQLPI LHHAYLPSIG
GVDASCVSPC VSPTASPRHR HVPPSFRVMV SGL
//