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Database: UniProt
Entry: A0A6J0AHN2_VICPA
LinkDB: A0A6J0AHN2_VICPA
Original site: A0A6J0AHN2_VICPA 
ID   A0A6J0AHN2_VICPA        Unreviewed;       813 AA.
AC   A0A6J0AHN2;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   05-FEB-2025, entry version 21.
DE   SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 isoform X2 {ECO:0000313|RefSeq:XP_015094451.1};
GN   Name=GABBR2 {ECO:0000313|RefSeq:XP_015094451.1};
OS   Vicugna pacos (Alpaca) (Lama pacos).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Vicugna.
OX   NCBI_TaxID=30538 {ECO:0000313|Proteomes:UP000504605, ECO:0000313|RefSeq:XP_015094451.1};
RN   [1] {ECO:0000313|RefSeq:XP_015094451.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_015094451.1};
RG   RefSeq;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC       receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR   RefSeq; XP_015094451.1; XM_015238965.2.
DR   AlphaFoldDB; A0A6J0AHN2; -.
DR   GeneID; 102526877; -.
DR   CTD; 9568; -.
DR   Proteomes; UP000504605; Chromosome 4.
DR   GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR   GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR   CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR   CDD; cd06366; PBP1_GABAb_receptor; 1.
DR   FunFam; 3.40.50.2300:FF:000063; Gamma-aminobutyric acid type B receptor subunit; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR041689; GBR2_CC.
DR   InterPro; IPR002455; GPCR3_GABA-B.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR   PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF18455; GBR2_CC; 1.
DR   PRINTS; PR01178; GABAB2RECPTR.
DR   PRINTS; PR01176; GABABRECEPTR.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170,
KW   ECO:0000313|RefSeq:XP_015094451.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000504605};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        351..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        525..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        568..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        590..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          353..635
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          635..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   813 AA;  92167 MW;  7BE4898EA0025D6B CRC64;
     MVFGGVCPSV TSIIAESLQG WNLVQLSFAA TTPVLADKKK YPYFFRTVPS DNAVNPAILK
     LLKHYQWKRV GTLTQDVQRF SEVRNDLTGV LYGEDIEISD TESFSNDPCT SVKKLKGNDV
     RIILGQFDQN MAAKVFCCAY EENMYGSKYQ WIIPGWYEPS WWEQVHTEAN SSRCLRKNLL
     AAMEGYIGVD FEPLSSKQIK TISGKTPQQY EREYNSKRSG VGPSKFHGYA YDGIWVIAKT
     LQRAMETLHA SSRHQRIQDF NYTDHTLGRI ILNAMNETNF FGVTGQVVFR NGERMGTIKF
     TQFQDRREVK VGEYNAVADT LEIINDTIRF QGSEPPKDKT IILEQLRKIS LPLYSILSAL
     TILGMIMASA FLFFNIKNRN QKLIKMSSPY MNNLIILGGM LSYASIFLFG LDGSFVSEKT
     FETLCTVRTW ILTVGYTTAF GAMFAKTWRV HAIFKNVKMK KKIIKDQKLL VIVGGMLLID
     LCILICWQAV DPLRRTVERY SMEPDPAGRD ISIRPLLEHC ENTHMTIWLG IVYAYKGLLM
     LFGCFLAWET RNVSIPALND SKYIGMSVYN VGIMCIIGAA VSFLTRDQPN VQFCIVALVI
     IFCSTITLCL VFVPKLITLR TNPDAATQNR RFQFTQNQKK EDSKTSTSVT SVNQASTSRL
     EGLQSENHRL RMKITELDKD LEEVTMQLQD TPEKTTYIKQ NHYQELNDIL NLGNFTESTD
     GGKAILKNHL DQNPQLQWNT TEPSRTCKDP IEDINSPEHI QRRLSLQLPI LHHAYLPSIG
     GVDASCVSPC VSPTASPRHR HVPPSFRVMV SGL
//
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