ID   A0A6F9C6F5_9TELE        Unreviewed;       933 AA.
AC   A0A6F9C6F5;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   05-FEB-2025, entry version 16.
DE   RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=CSTEINMANNI_LOCUS3750927 {ECO:0000313|EMBL:CAB1344204.1};
OS   Coregonus sp. 'balchen'.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Coregoninae; Coregonus.
OX   NCBI_TaxID=861768 {ECO:0000313|EMBL:CAB1344204.1, ECO:0000313|Proteomes:UP000502089};
RN   [1] {ECO:0000313|EMBL:CAB1344204.1, ECO:0000313|Proteomes:UP000502089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   De-Kayne R.;
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
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DR   EMBL; LR778290; CAB1344204.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A6F9C6F5; -.
DR   OrthoDB; 8950220at2759; -.
DR   Proteomes; UP000502089; Chromosome 38.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd01671; CARD; 1.
DR   CDD; cd08321; Pyrin_ASC-like; 2.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 3.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   Pfam; PF02758; PYRIN; 2.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM01289; PYRIN; 2.
DR   SUPFAM; SSF47986; DEATH domain; 3.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50824; DAPIN; 2.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000502089}.
FT   DOMAIN          9..91
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          156..238
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          558..846
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          849..932
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   REGION          459..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAB1344204.1"
SQ   SEQUENCE   933 AA;  106946 MW;  A84BE95503DF225F CRC64;
     RTLVFPALLL TTLEEMNPHE LKTFQSFLTS GLLPDCPPIP ESQLENADRQ VTVDQMVKTY
     GPERAVEITL RILRGMKRVD LAEKLETDHR GGNRTRMYIN LYITITVQWR YCLNLSPALS
     PTRPRSVLSP VWLPPISPLL SSSIFFPRML AVPALLLTTL EEMNPHELKT FQSFLTSGLL
     PDCPPIPESQ LENADRQVTV DQMVKTYGPE RAVEITLRIL RGMKRVDLAE KLETDHRGGN
     RTRMYINLYI TITVQCRSNQ KEHSTDSIIT FSRPLFYHFY SCCIQVTPLC LNSNPTFIIL
     HTYNYQYSRE DFTNRLDFLI MAVYLFLSFL IWKMNQNDLA EKLERDQRST ASTSPLCGYP
     PRPPFLYPGS SEEVLSLTSA GSSGNFISQR PQILSGSALL LTTPEELTEE QLTNDELLSV
     LSIPESQLEN ADIQVTVDQM ERYDSLRAMG ITETFDRYHS RGKKRRTNEP PSWPVLVSRD
     KKSEEDCVPL TDGAPPIIKH KETPKLEMDC PPILDIPLEM ANSVNTEVAV NTQENTQRMD
     EELGRERDSP LFLEHHHMSS PDEFTPEIHD QDNRREYQFQ CLRSGLFQCS ITGLVFRMEG
     EGEVLYRTVP WNRRLLAQSG KRPAGPLFKL TCLKGSVCQL HLPHCEIYNS GLPCDFLSVA
     HVTDENMEFI RPHKITETHV IIKISGFSAY GDVKDEDSPT VPIRALVLLF YKPPVVPKKR
     SILNVLLLPR NVVIREVQEE WIRRNEDRNI YIETNSHCQL TPNQEYNLST DLTDEYLIKP
     KDAEFVDFES YENYIPTFQL FIQTVVEQVN LLLKKKMVVI LIHNFPLPVS AVSPAAPPAN
     PSTLPGRGFI RNHRMALETR LGLLQPLFHR LQDHGVLIDE EREEVVSKSS KTLQNQALLD
     MVVRKGARAQ EHFYQVLKEV DPYLVEDLEE QTV
//