ID   A0A674D138_SALTR        Unreviewed;       367 AA.
AC   A0A674D138;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   05-FEB-2025, entry version 21.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 1b allele 3-like {ECO:0000313|Ensembl:ENSSTUP00000089463.1};
GN   Name=LOC115190792 {ECO:0000313|Ensembl:ENSSTUP00000089463.1};
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000089463.1, ECO:0000313|Proteomes:UP000472277};
RN   [1] {ECO:0000313|Ensembl:ENSSTUP00000089463.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A674D138; -.
DR   Ensembl; ENSSTUT00000095154.1; ENSSTUP00000089463.1; ENSSTUG00000039311.1.
DR   GeneTree; ENSGT00940000154395; -.
DR   Proteomes; UP000472277; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08325; CARD_CASP1-like; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472277}.
FT   DOMAIN          1..259
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          270..362
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   REGION          252..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  42259 MW;  F11CA7B6E5759068 CRC64;
     MFRHRTPKGS YECTVSGLRW LCERDVILKY HFRNWDPYSQ LLKDMQYTQG GPLLDITMEL
     GELEEVHLPH CVCLGTNPSL RNEMKILHVE EHGVSLEEVH EVTRFHAKIL HPKFSPIGPI
     LRLLSWDVDV HCELMLYLTV KRETLISRLY LFPWNPSQIQ AVEQQEKSHG SSRFLISRPE
     QSFKLNSSFR LNIPCSTSIN PPRIHFIQRD TTPSFFKAIV KMTGVDIEME LFSDDERTVW
     KEMVSHDEYV TDTRSTSAVS GAGRPAESSL TGSPEQQLRS VRTEFVKRVS GPVLNELLDR
     LLQHTVINQE EMESVKVIAE RTEKARDIID MVLRKGTESC SRMINLLGEL DHCLYTELQI
     NSVGVPT
//