ID   A0A672S050_SINGR        Unreviewed;       331 AA.
AC   A0A672S050;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   05-FEB-2025, entry version 20.
DE   SubName: Full=NOD-like receptor family B, member 5 {ECO:0000313|Ensembl:ENSSGRP00000094625.1};
OS   Sinocyclocheilus grahami (Dianchi golden-line fish) (Barbus grahami).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Sinocyclocheilus.
OX   NCBI_TaxID=75366 {ECO:0000313|Ensembl:ENSSGRP00000094625.1, ECO:0000313|Proteomes:UP000472262};
RN   [1] {ECO:0000313|Ensembl:ENSSGRP00000094625.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
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DR   AlphaFoldDB; A0A672S050; -.
DR   Ensembl; ENSSGRT00000100693.1; ENSSGRP00000094625.1; ENSSGRG00000047329.1.
DR   Proteomes; UP000472262; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472262}.
FT   DOMAIN          1..239
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          241..331
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
SQ   SEQUENCE   331 AA;  37705 MW;  6F3260FC75404F49 CRC64;
     MEGEGEVLYS VVSWDPGLLH SLGQMRPAGP LYNIDCSAKS VLRLHLPHCV IFSEEDKDGL
     AVAHFTGGNI EIIQPLKVTE THVIIDIREL SRFGLIWIKT ILGFPIDGQV LLFLRPVTVE
     QEQKILNVHL LPGNVPVTEV QRLHHNKSYI ETTSKCRLFT DREYSLCCQP EDCEVQPMRE
     MFQLDNFGPN YHPTFEVFLD VNIKEVRLAV LDKTEDGKEV WPRRRIPLTA PSKGVEPPAH
     RRIPETEFVN THGDKLIQRV SSVMAIADSL KSKNIITPEM WSKIHVAETR QEKMRLLLNA
     LESKGDNAKI EFCRLLKKNE SDLVNELGPH L
//