ID A0A673Z4J8_SALTR Unreviewed; 2188 AA.
AC A0A673Z4J8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 05-FEB-2025, entry version 22.
DE SubName: Full=Uncharacterized LOC115201125 {ECO:0000313|Ensembl:ENSSTUP00000041201.1};
GN Name=LOC115201125 {ECO:0000313|Ensembl:ENSSTUP00000041201.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000041201.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000041201.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
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DR Ensembl; ENSSTUT00000043044.1; ENSSTUP00000041201.1; ENSSTUG00000017486.1.
DR GeneTree; ENSGT00730000111912; -.
DR InParanoid; A0A673Z4J8; -.
DR OMA; HATFIVF; -.
DR Proteomes; UP000472277; Chromosome 10.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.20.58.1200; RNA silencing suppressor P21, N-terminal domain; 3.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR052090; Cytolytic_pore-forming_toxin.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR31594; AIG1-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31594:SF16; SI:CH211-281L24.3; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 4..79
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 208..329
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1813..2089
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 2096..2181
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
SQ SEQUENCE 2188 AA; 250032 MW; E4A1FB5A5D3C307F CRC64;
MASTEQSAVD YIQNGRRLLV DSLENPSLVI DHLHKHMVLN QEEVSYLSSM YEKSDRSRKM
LDMTVCKGEA ACYELLKILY TTRKVSLKQH MHYWISCFSF RDDPKLQSDF TPTDSKPCFK
YMKQLKLKAK QICEARRKKR MYWLKKSCTL KPFTYIPLVL DPDRSVFQKS KISKSKAYKK
SRSKKLQTYI PAFKRKLSPD NLLTGNEKKI LLVGKPGIGK TTVAQEILNL WAQKEDNAVS
YMFYFNESLM RSMSHSDDPT TLKSLLFGKY VKPEEGIEEI LQDIEQNSEN VIIVFDGIMD
TIRNSVVKRI LEKDLLCDAK IVTTCRPEAE DCGFLSDWPS YRVEVHGFND ESISSFFRWM
FDTDEDTICR ILNNPELFSL CHVPMYAFIV TGCICLSVSE AKDHPCTVTE MYVQIFRDSL
KICNDQTTEH LDKDMHDQKQ ALRSLAESAY QAMLGKTANV TRLDGKDHSV LDAFLTPSAA
KDTSTSSWAF LHNTLQEFWA SVFLLMTPDK ITQVLQQCQT EEGKYLKHIF SFLCGLCSQS
SNMVESIKFL ISEEEVRELS DQYIEKIIDS FIYCETQQDP DESNSDVENL LFICQCLYEH
QSPEACLLLL EKVGYKFNLS GEQLDPQQCC AVSYVINQSK DRNVRLDLED CSLSDPGLRL
ILRALENLTM LRLDSITQLQ MWKVALRSGL QSDCDNLLRL CESEIHLSVQ EQEVWKPAEE
VLKLKRPEHI HLCLHVGQGT QHITTSSMKI IFDCLSNIAN IRFIALNDQK THSWNEEVKS
FQMDLYIQGA LYEMTTGQKR VEGLRPVLAH LIHSDSIEEQ SKFMVRLYSK AHDTQEGVLP
VLQPVFQTTP AVWYIDLSEK GTSGVLEVLK FQNVKKPVEL WWSDEESERE LAIFLQCLPY
VSELRFNDCI PNTNDAIKVL VDLFICAATL EGETLNMLSS VCGYSAFPFA DRDNAGQCAF
LLDLYSHVSD YETQTGRSIL PALLPLYQTA PAVWSIDLSE RKASLLLEVL KLQPEKKPVE
LRGWPDDESD VRSFLQCLPY ISYLRFFYRQ DEGELPEEWR ITFFPWLCCL LLKVFLQGAV
NDILTGQRSV EALLSVLGLA HSYDSTEKCM LLLDLYSQAK DDEIQTGRSI LPALQPIYWS
TPAVWSIDLT ESKASLLLEV LKLQPVKKPV ELRGCSDDES DVRSFLQCLP YISYLICDCQ
FFLSMCDELS VGSEGDALLS HSLLQALQYT LTLSGWLPSV SCEAVGAVLG QSTADDELDV
TLTPQSISLQ GAKLLFEQVK ELHKLRMNEM ATVKLARMSL LCKRPMFVKE LTLVLSRPNP
TERVQCRVIS SLASLLTVWT IRSLDLTDCP IEGYLLATLL CHQGPLTIRL SEEILQQLAV
VVYEAQNEEL TQCFLEKVDG DLSNCRLDWD VLHYLLKSTT KRITVNLRRS RIRQQDMPHL
LPFLNNIRFQ RMNSHFERTA LKEIHKQRAG HMVITLVRSS DEWINLNNLV LKHDDCEALR
FGLHYSDGVK LNLLWTVIPK EEMGRFLTLL HRVSELRVDR KLLLELLHAW TGLITQTEAP
AALLRVLDHK LDLSCSSAMD LSGQEDDTVL SLSSGDCRAI SAAIDKADGD TELILHDCQI
EDAGLEEFYK ESILQRVHLS LGKPILLQLL HLIFVGDGGR SERLASLLSR ALGKELDLSH
TPLDLMACSS LALILEHSEG LSELDLSDCH LTDTHLEFLL THLHKAQVLN LCNNEITDEG
AVKLNLYMIG NSFTETVWLC NNKITEFDSF LADKRYKLWP AHVSGMQDRH VTNLGSTSVR
EETSKVFSKT KPIIKEFDPE IVEEVEESKI SYRFQCGIRG KFQCSATGLV FGMREPGTVE
YSVEHWDMHM LADTDSEPAC PVFKISCPEG HMYQLHLLHC ETEVYAAEAL SVAHICSNSL
EILVPNRVTH SHVIININGL SRWTLFRRKP KTKKRINGQV LLFLELNVTE GQHRLWVYLL
SRNVPYTEVM KRNKKLEFIR ACSDCYLRPE ARYRVTSDLE QGFSVHPKDK YLHIHSGPDQ
HATFIVFLDS KVTKLKLMIQ ELKRMGQKTA WRSQWFEPIF LKPGSNLTES DWLQNLCCIL
EHLSPKEIKR LKFLVRTSKE LPQPSISNND LECLEELHDL AELMVKSWGM NGSISATQLL
MKELPRRDEP VTSLLMPFLE QCVVLKGA
//