ID   A0A673APV5_9TELE        Unreviewed;       460 AA.
AC   A0A673APV5;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   05-FEB-2025, entry version 20.
DE   RecName: Full=FIIND domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005030573.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005030573.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Wellcome Sanger Institute Data Sharing;
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSORP00005030573.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
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DR   AlphaFoldDB; A0A673APV5; -.
DR   Ensembl; ENSSORT00005031431.1; ENSSORP00005030573.1; ENSSORG00005014586.1.
DR   InParanoid; A0A673APV5; -.
DR   Proteomes; UP000472271; Chromosome 20.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08321; Pyrin_ASC-like; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50168; DED; 1.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271}.
FT   DOMAIN          69..364
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          368..460
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          375..458
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   REGION          15..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  51954 MW;  0AEDA8FD9485825E CRC64;
     MCHFIGLKEG PHVSLMSADS LHPPGPSTSD SDLKEVEDGG QDCVDRDPHL NPADPEKQQL
     VCTEVQARAS TWEEFTPEVS AESGLTSYRF RCPHSGAFRC TWTGLVFVVT REAGLKYRTV
     QWDEPLLRSA GRTPAGPLFS IDSPENAVCQ LHLPHCETKP GQRSKSLLSV VHITDDGMEF
     IEPLEITDTH VVIDVPHLSV FGLVWVWERI QNLISVGGQM DESTSQCSRS VLGQVLLFLK
     PPNPRKQRQK LDVLLLPVNV PVEDVKTFVQ QQWPDALYID VTPQCDLITN HKYRVECPEA
     CLIQPKENRF DLNFGPNYHK MFEIRLPTNT EEVTLTIRDQ ENSDVWTHEV DLPGPGTEEN
     LPRAVQNISP EEQSSTAETL LHILDQVAED DFKTFKFHLQ YVVRGNVQPI PVHRLENAER
     TTVVDLMVQT YEESGAVEVT KTLLQKIRRS DLVKKLTDIC
//