ID A0A669BCS4_ORENI Unreviewed; 585 AA.
AC A0A669BCS4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 05-FEB-2025, entry version 19.
DE RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000033311.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000033311.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR AlphaFoldDB; A0A669BCS4; -.
DR Ensembl; ENSONIT00000044649.1; ENSONIP00000033311.1; ENSONIG00000033419.1.
DR GeneTree; ENSGT00940000178015; -.
DR InParanoid; A0A669BCS4; -.
DR OMA; QQYHAEG; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 3.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF02758; PYRIN; 2.
DR SMART; SM01289; PYRIN; 2.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 122..205
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 308..585
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
SQ SEQUENCE 585 AA; 66271 MW; D5C893BF4026F6ED CRC64;
MGDMLETVQV WDSPNTPVEE GKEDVLLREL SKLPIVELWR IQWGLSQSAL LQDFPPIPPR
WLRSADACST AKTMMRCYQE DRAPAVLAAV QTLISGNHQV RPVRFTMIPL RPESDLKPVQ
GFVKTQRRKL ISRIQRPGPI LEALQCCRIF NTSEREAIAI YGACKDRNRA LVDLLLRKGE
EAQKVFYHAL GQSEPFLLQE LEEDHIRGKN ASDSVVIMEM LEFLVTDELK CFQWLVNKYM
TAESHSPIGG EQLEHADRRT TWRLLEKLFG SNRAERVAME ILMKIVPMLC LYFQAEAVTS
LTYSDIRLET NTPQVEITPE VSEDGSIFRL RCQQPGVFRC SLTGLVLEGF GDVVYEMVPW
DVDFLSSKGL QVAGALFRFH LLTGSFQRLH LPHCQLLSDG GRHFLSVAHV TGDCVDFITP
GQVTDSHVTV DISGFSCFGL VTPAPSDQIA GLVLIFSQPT NSTLFILLLP RNVCLTQVRK
EWKRRIGAEY IEAIPDCELI PNHTYKLIGE PVTVIQPETS KFVNFRDYNN FLPSFQVQLK
AGATQVRLQL RSHVAGSRLI GWLFGNKECE VWARVIQLKG NSHYM
//