ID   A0A4W5N5K0_9TELE        Unreviewed;       302 AA.
AC   A0A4W5N5K0;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   05-FEB-2025, entry version 25.
DE   RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Hucho hucho (huchen).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Hucho.
OX   NCBI_TaxID=62062 {ECO:0000313|Ensembl:ENSHHUP00000046811.1, ECO:0000313|Proteomes:UP000314982};
RN   [1] {ECO:0000313|Proteomes:UP000314982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Macqueen D.J., Gundappa M.K.;
RT   "Genome assembly of Danube salmon.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSHHUP00000046811.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A4W5N5K0; -.
DR   STRING; 62062.ENSHHUP00000046811; -.
DR   Ensembl; ENSHHUT00000048528.1; ENSHHUP00000046811.1; ENSHHUG00000028479.1.
DR   GeneTree; ENSGT01120000272084; -.
DR   Proteomes; UP000314982; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08330; CARD_ASC_NALP1; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR051249; NLRP_Inflammasome.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS51830; FIIND; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314982}.
FT   DOMAIN          1..217
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          212..302
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
SQ   SEQUENCE   302 AA;  34627 MW;  910C89E904F44F95 CRC64;
     MGYRQGGPLL DIKIIEGKLK EVHLPHFACF GARVGDCYDP SIKQKVRVLH VEERGVSIEQ
     VDKVTRFHVK ILHPSFSLRG VILQALGCSV HCDFQIYRAR TAHLTLHAYL MPCDPALTQA
     VEKQERCHGS TRILKPRPEK SQWLTSDFYL TTSCPSDVNP RRLELAHDDP PNFFEVFIRD
     ADFDFSLNLS CKSRKQTIWN HEIREVEYRG PILTSDQHFV DLHQTALIDR VSQVDPILDR
     LLKSGVITAD GYSDVIAEKN NQKKMRELFD GPLKGCGPEG KDQFLEILTE LEPYLINHLK
     RE
//