ID A0A2K5MJF0_CERAT Unreviewed; 1450 AA.
AC A0A2K5MJF0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 05-FEB-2025, entry version 36.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSCATP00000025341.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSCATP00000025341.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000025341.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000025341.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR Ensembl; ENSCATT00000049571.1; ENSCATP00000025341.1; ENSCATG00000036133.1.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000233060; Unassembled WGS sequence.
DR Bgee; ENSCATG00000036133; Expressed in lymph node and 3 other cell types or tissues.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR FunFam; 1.10.533.10:FF:000013; Apoptosis-associated speck-like protein containing a CARD; 1.
DR FunFam; 1.10.533.10:FF:000049; NLR family pyrin domain containing 1; 1.
DR FunFam; 3.40.50.300:FF:000897; NLR family pyrin domain containing 1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR InterPro; IPR041075; NOD1/2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 332..641
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1056..1341
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1357..1440
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 162..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 162976 MW; 0718D623D44D5E7E CRC64;
MAGGAWGRLA CYLELLKKEE LKEFQLLFTS KVHSSGSSGE TPARPEKTSG MEVASYLVAQ
YGEQRAWDLA LRTWEQMGLW SLCTQAWEGA SYSPSFPYSP SEPHLGSPSQ PTSTAVLRPW
NRELPAECTQ GSERRVLRQL PDTSGHRWRE ISSSLLYQAF PSSPDFESPS QESPNAPTST
AVLASWGSPP QPSLAPREQE APGTQWPLDE TSGNYYTGIR EREREESEKG RPPWEAAVGT
PPQVHTSLQP HHHPWEPSAR ESLCSTWSWK NEDLNQNFTQ LLLLQRPHPR NHKPLVKGSW
PHDAEEDVEE DRGRLIEIRD LFGPGLDTQE PRIVILQGAA GIGKSTLARQ VREAWGRGQL
YGDRFQHVFY LSCRELAQCE AVSLAELIGK DWTAAQAPIR QILSRPERLL FILDGVDEPR
WVLQESSSEL CLHWSQPQPA DALLGSLLGK TILPEASFLI TARTTALQNL IPSLEQARWV
EVLGFSESSR REYFYKYFTD ERQAIRAFGL IKTNKELWAL CLVPWVSWLA CTCLMEQMKR
KEKLTLTSKT TTTLCLHYLS QALQAQPLGP QLGDVCSLAA EGIWQKKTLF SRDDLRKHEL
DGAIISTLLK MGILQEHPIP LSYSFIHLCF QEFFAAMSYA LEDKKGRSKH ANCIIDLEKL
LEAYGTHGLF GAPTTRFLLG LLSDEGKRAM ENIFNCRLSQ GRNLMQWVPS LWPLLQPHSL
DFLHCLYETQ NKMFLTQMMA NFQEMGMCVE TDMELLVCTF CIQFCRHVKK LQLIEGRQHR
PAWSPTGIVL FRWVPVTDAY WEILFSVFKV TRNLKELDLS GNSLSHSAVK SLCKTLRRPR
CLLETLRLAS CGLTAEDCKD LASGLRVNQN LTVLDLSFNV LTDAGARHLC QRLSWPRCTL
QRLQLVSCGL TSGCCQDLAS VLSASPFLME LDLQQNNLGD TGVRLLCEGL RHPACQLTRL
GKPTGMIPDE GLGTGETSNS TSSLKRQRLG SETESSHVAQ ADFKPLDWSN PPAKASQIAG
ITEGSSPEVE QVEPLCLPSP ASLGDQDTPL GTDDDFWGPT GPVATEVVDK ERSRYRVHFP
VAGSYRWPNT GLCFVVREAV TTEIEFCVWD QFLGEINPQH SWMVAGPLLD LKAEPGAVEA
VHLPHFVALQ GGHVDTSLFQ VAHFKEEGML LEKPARVELH HIVLENPSFS PLGVLLKVIH
GTLRFFPVNS LVLLYHRLHP EEVTFHLYLI PSDCSIRKAI DDEETKFQFV RIHKPPPLTP
LYMGCRYTVS GSGLGMLEIL PKELELCYRS PGEAQLFSEF YVGHLGSGIR LQMKDKKDET
LVWEALVKPG DLAPAATLVP PAPIALPSSL DAPGLLHFVD QYREQLIARV TSVEVVLDKL
YGQVLSQEQY ERVLAEDTRP SQMRKLFSLS QSWDRRCKDQ LYQALKETHP HLIMELWEKG
SKKGLLPLSS
//