ID A0A2I3SPR1_PANTR Unreviewed; 537 AA.
AC A0A2I3SPR1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 05-FEB-2025, entry version 28.
DE SubName: Full=Caspase recruitment domain family member 8 {ECO:0000313|Ensembl:ENSPTRP00000078955.1};
GN Name=CARD8 {ECO:0000313|VGNC:VGNC:10941};
GN Synonyms=LOC129135367 {ECO:0000313|Ensembl:ENSPTRP00000078955.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078955.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078955.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000078955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR EMBL; AACZ04019567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3SPR1; -.
DR PaxDb; 9598-ENSPTRP00000044761; -.
DR Ensembl; ENSPTRT00000078404.1; ENSPTRP00000078955.1; ENSPTRG00000023499.5.
DR VGNC; VGNC:10941; CARD8.
DR GeneTree; ENSGT00830000128447; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000023499; Expressed in bone marrow and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR FunFam; 1.10.533.10:FF:000090; Caspase recruitment domain family member 8; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR051249; NLRP_Inflammasome.
DR PANTHER; PTHR46985:SF4; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 161..446
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 453..536
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 458..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 60662 MW; E93939B861AE48FB CRC64;
MEKKEFPEKS SSSEEELPRP HSGSSRNTDA SKLIRLQGPR KLLVDNSIRE LQYTKTGIFL
QAEACVTNDT VYRELPRVSE IRCDISHFFQ DDDETEAEPL LFRAVPECQL SGGDIPSVSE
EQESSEGQDS GDICSEENQI VSSYASKVCF EIEQDYKNHQ FLGPEGNVDV ELIDKSTNTY
SVWFPTAGWY LWSATGLGFL VRDAVTVTIA FGSWNQHLAL DLQHHEQWLV GGPLFDVTAE
PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKDEGMVLEY PARVEPFYAV LEKPSFSLMG
ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE EDRFHGVRLQ
TSPPVEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ HFSKFYAGQM KEPIQLEITE
KRHGTLVWDT EVKPVDLQLA AASAPPPFSG AAFVKENHRQ LQARMGDLKG VLDDLQDNEV
LTENEKELVE QEKTRQSKNE ALLSMVEKKG DRALDVLFRS ISERDPYLVS YLRQQNL
//