ID A0A1U7SSS4_CARSF Unreviewed; 451 AA.
AC A0A1U7SSS4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE SubName: Full=Tyrosine 3-monooxygenase {ECO:0000313|RefSeq:XP_008047208.1};
GN Name=TH {ECO:0000313|RefSeq:XP_008047208.1};
OS Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC Carlito.
OX NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_008047208.1};
RN [1] {ECO:0000313|RefSeq:XP_008047208.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR RefSeq; XP_008047208.1; XM_008049017.1.
DR AlphaFoldDB; A0A1U7SSS4; -.
DR STRING; 1868482.ENSTSYP00000019537; -.
DR GeneID; 103250431; -.
DR KEGG; csyr:103250431; -.
DR CTD; 7054; -.
DR OrthoDB; 983542at2759; -.
DR Proteomes; UP000189704; Unplaced.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR GO; GO:0007507; P:heart development; IEA:TreeGrafter.
DR GO; GO:0045471; P:response to ethanol; IEA:TreeGrafter.
DR GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter.
DR CDD; cd04930; ACT_TH; 1.
DR FunFam; 3.30.70.260:FF:000024; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR InterPro; IPR021164; Tyrosine_hydroxylase_CS.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR Pfam; PF21417; TH_ACT; 1.
DR Pfam; PF12549; TOH_N; 2.
DR PIRSF; PIRSF000336; TH; 2.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 2.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189704}.
FT DOMAIN 152..321
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT DOMAIN 323..451
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 329
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
SQ SEQUENCE 451 AA; 50740 MW; EA0046BDF6F4610E CRC64;
MPTPNAATPQ AKGFRRAVSE LDAKQAEAIM SPRFIGRRQS LIEDARKERE AAVAAAAAAA
ASSEPGDPLE AVAFEEKEGR AVLNLVFSLR GAKPSVLSRA VRVFETFEAR IHHLETRPAQ
RPRAGGAQLE YFVRCEVPRG DLVALLSSVR QVAEDVRSAR EDKAPWFPRK VSELDKCHHL
VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI AFQYKHGDPI PRVEYTAEEI ATWKEVYTTL
RSLYATHACR EHLEAFALLE RFSGYREDSI PQLEDVSRFL KERTGFQLRP VAGLLSARDF
LASLAFRVFQ CTQYIRHASS PMLYWFTVEF GLCKQNGEVK AYGAGLLSSY GELLHCLSEE
PEVRAFDPEA AAVQPYQDQT YQSVYFVSES FSDAKDKLRS YATRIQRPFS VKFDPYTLAV
DVLDSPHAVL RSLEGVQDEL HTLAHALSAI G
//