ID A0A1S3WEU7_ERIEU Unreviewed; 883 AA.
AC A0A1S3WEU7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 05-FEB-2025, entry version 36.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|RefSeq:XP_016044807.1};
GN Name=GABBR2 {ECO:0000313|RefSeq:XP_016044807.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016044807.1};
RN [1] {ECO:0000313|RefSeq:XP_016044807.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (OCT-2024) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016044807.1; XM_016189321.1.
DR AlphaFoldDB; A0A1S3WEU7; -.
DR GeneID; 103115733; -.
DR CTD; 9568; -.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; A0A1S3WEU7; -.
DR OrthoDB; 2150267at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR FunFam; 3.40.50.2300:FF:000072; Gamma-aminobutyric acid type B receptor subunit 2; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_016044807.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 421..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 423..705
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 705..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 100095 MW; 9E6FFEF78C0B35F5 CRC64;
MGLMPLTKEV AKGSIGRGVL PAVELAIEQI RNESLLRPYF LDLRLYDTEC DNAKGLKAFY
DAIKYGPNHL MVFGGVCPSV TSIIAESLQG WNLVQLSFAA TTPVLADKKK YPYFFRTVPS
DNAVNPAILK LLKHYQWKRV GTLTQDVQRF SEVRNDLTGV LYGEDIEISD TESFSNDPCT
SVKKLKGNDV RIILGQFDQH MAAKVFCCAY EENMYGSKYQ WIIPGWYEPF WWEQVHMEAN
SSRCLRKNML AAMEGYIGVD FEPLSSKQIK TISGKTPQQY EREYNSKRSG VGPSKFHGYA
YDGIWVIAKT LQRAMETLHA SSRHQRIQDF NYTDHTLGRI ILNAMNETNF FGVTGQVVFR
NGERMGTIKF TQFQDSRELK VGEYNAVADT LEIINDTIRF QGSEPPKDKT IILEQLRKIS
LPLYSILSAL TILGMIMASA FLFFNIKNRN QKLIKMSSPY MNNLIILGGM LSYASIFLFG
LDGSFVSEKT FETLCTVRTW ILTVGYTTAF GAMFAKTWRV HAIFKNVKMK KKIIKDQKLL
VIVGGMLLID LCILICWQAV DPLRRTVERY SMEPDPAGRD ISIRPLLEHC ENTHMTIWLG
IVYAYKGLLM LFGCFLAWET RNVSIPALND SKYIGMSVYN VGIMCIIGAA VSFLTRDQPN
VQFCIVALVI IFCSTITLCL VFVPKLITLR TNPDAATQNR RFQFTQNQKK EDSKTSTSVT
SVNQASTSRL EGLQSENHRL RMKITELDKD LEEVTMQLQD TPEKTTYIKQ NHYQELDDIL
NLGNFTESTD GGKTILKNHL DQNPQLQWNT TEPSRTCKDP IEDINSPEHI QRRLSLQLPI
LHHAYLPSIG GVDASCVSPC VSPTASPRHR HVPPSFRVMV SGL
//