ID A0A091K3V0_COLST Unreviewed; 394 AA.
AC A0A091K3V0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-NOV-2024, entry version 30.
DE RecName: Full=Tyrosine 3-monooxygenase {ECO:0000256|ARBA:ARBA00017181};
DE EC=1.14.16.2 {ECO:0000256|ARBA:ARBA00011993};
DE AltName: Full=Tyrosine 3-hydroxylase {ECO:0000256|ARBA:ARBA00032379};
DE Flags: Fragment;
GN ORFNames=N325_11722 {ECO:0000313|EMBL:KFP30863.1};
OS Colius striatus (Speckled mousebird).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Coliiformes; Coliidae; Colius.
OX NCBI_TaxID=57412 {ECO:0000313|EMBL:KFP30863.1, ECO:0000313|Proteomes:UP000053615};
RN [1] {ECO:0000313|EMBL:KFP30863.1, ECO:0000313|Proteomes:UP000053615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N325 {ECO:0000313|EMBL:KFP30863.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine
CC from L-tyrosine: step 1/2. {ECO:0000256|ARBA:ARBA00004700}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; KK540948; KFP30863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091K3V0; -.
DR UniPathway; UPA00747; UER00733.
DR Proteomes; UP000053615; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter.
DR CDD; cd03345; eu_TyrOH; 1.
DR FunFam; 1.10.800.10:FF:000002; Tyrosine 3-monooxygenase; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR041903; Eu_TyrOH_cat.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR005962; Tyr_3_mOase.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR NCBIfam; TIGR01269; Tyr_3_monoox; 1.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR Pfam; PF21417; TH_ACT; 1.
DR PIRSF; PIRSF000336; TH; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Catecholamine biosynthesis {ECO:0000256|ARBA:ARBA00022584};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:KFP30863.1};
KW Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053615}.
FT DOMAIN 48..394
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 227
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 232
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 272
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFP30863.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:KFP30863.1"
SQ SEQUENCE 394 AA; 45421 MW; CF836FBE8FF1FB65 CRC64;
KTFEAKIHHL ETRLSRKPRE GTTELEYFVR CEVHSSDLNT FISSIKRVAE DVRTTKEDKF
HWFPRKICEL DKCHHLVTKF DPDLDLDHPG YSDQVYRQRR KSIAEIAFHY KHGDPIPHVE
YTAEEIATWK EVYSTLKSLY PTHACKEYLE AFNLLEKFCG YNENNIPQLE EVSRFLKERT
GFQLRPVAGL LSARDFLASL AFRVFQCTQY IRHASSPMHS PEPDCCHELL GHVPMLADKT
FAQFSQDIGL ASLGATDEEI EKLATLYWFT VEFGLCRQNG IVKAYGAGLL SSYGELIHSL
SDEPEVRDFD PDAAAVQPYQ DQNYQPVYFV SESFSDAKNK LRSYAAHIKR PFSVKYEPYT
HSIELLDSPQ TICHSLENVR DELHSLINAL NVIS
//