UniProt: M3Y393

Database: UniProt
Entry: M3Y393_MUSPF

LinkDB:  M3Y393_MUSPF 
Original site:  M3Y393_MUSPF

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Ontology (29)   
   GO (29)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (10)   
   EMBL (10)   
Protein domain (6)   
   InterPro (3)   
   Pfam (2)   
   PROSITE (1)   
All databases (51)   

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ID   M3Y393_MUSPF            Unreviewed;       188 AA.
AC   M3Y393;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   18-JUN-2025, entry version 60.
DE   RecName: Full=COMM domain-containing protein 1 {ECO:0000256|ARBA:ARBA00016551};
GN   Name=COMMD1 {ECO:0000313|Ensembl:ENSMPUP00000005794.1,
GN   ECO:0000313|RefSeq:XP_004742092.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005794.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000005794.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2024) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004742092.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004742092.1};
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
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DR   EMBL; AEYP01010113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01010122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004742092.1; XM_004742035.3.
DR   FunCoup; M3Y393; 13.
DR   STRING; 9669.ENSMPUP00000005794; -.
DR   Ensembl; ENSMPUT00000005894.1; ENSMPUP00000005794.1; ENSMPUG00000005842.1.
DR   GeneID; 101670987; -.
DR   KEGG; mpuf:101670987; -.
DR   CTD; 150684; -.
DR   eggNOG; ENOG502RXN6; Eukaryota.
DR   HOGENOM; CLU_126878_0_0_1; -.
DR   OMA; MPTAIVE; -.
DR   OrthoDB; 10251426at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0055070; P:copper ion homeostasis; IEA:Ensembl.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:Ensembl.
DR   GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:1902072; P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway; IEA:Ensembl.
DR   GO; GO:2000009; P:negative regulation of protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:1902306; P:negative regulation of sodium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:Ensembl.
DR   GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR   GO; GO:1904109; P:positive regulation of cholesterol import; IEA:Ensembl.
DR   GO; GO:1905751; P:positive regulation of endosome to plasma membrane protein transport; IEA:Ensembl.
DR   GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR   GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   CDD; cd04749; Commd1_MURR1; 1.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR033776; COMMD1_N.
DR   InterPro; IPR037351; Murr1.
DR   PANTHER; PTHR21199; COMM DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR21199:SF1; COMM DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   Pfam; PF17221; COMMD1_N; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT   DOMAIN          117..185
FT                   /note="COMM"
FT                   /evidence="ECO:0000259|PROSITE:PS51269"
SQ   SEQUENCE   188 AA;  21004 MW;  0484AC270755BD35 CRC64;
     MAGELESSKA LSGLLNGLAQ EAFYGHQGIT EELLRSQLYP EVSLEEFRPF LAKMRGILKS
     IASADMDFNQ LEAFLTAQTK KQGGISSDQA AVISKFWKSH KIKIRESLMN QSRWDSGLRG
     LSWRVDGKSQ SRHSAQIHTP VAIMELEIGK SGQESEFLCL EFDEVKVNQL LKKLSEVEES
     ISTLMQPA
//

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