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KEGG   Symphalangus syndactylus (siamang): 129493473
Entry
129493473         CDS       T10134                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ssyn  Symphalangus syndactylus (siamang)
Pathway
ssyn00562  Inositol phosphate metabolism
ssyn01100  Metabolic pathways
ssyn01521  EGFR tyrosine kinase inhibitor resistance
ssyn04012  ErbB signaling pathway
ssyn04014  Ras signaling pathway
ssyn04020  Calcium signaling pathway
ssyn04062  Chemokine signaling pathway
ssyn04064  NF-kappa B signaling pathway
ssyn04066  HIF-1 signaling pathway
ssyn04070  Phosphatidylinositol signaling system
ssyn04072  Phospholipase D signaling pathway
ssyn04360  Axon guidance
ssyn04370  VEGF signaling pathway
ssyn04380  Osteoclast differentiation
ssyn04611  Platelet activation
ssyn04613  Neutrophil extracellular trap formation
ssyn04625  C-type lectin receptor signaling pathway
ssyn04650  Natural killer cell mediated cytotoxicity
ssyn04662  B cell receptor signaling pathway
ssyn04664  Fc epsilon RI signaling pathway
ssyn04666  Fc gamma R-mediated phagocytosis
ssyn04670  Leukocyte transendothelial migration
ssyn04722  Neurotrophin signaling pathway
ssyn04750  Inflammatory mediator regulation of TRP channels
ssyn04919  Thyroid hormone signaling pathway
ssyn04933  AGE-RAGE signaling pathway in diabetic complications
ssyn04935  Growth hormone synthesis, secretion and action
ssyn05167  Kaposi sarcoma-associated herpesvirus infection
ssyn05169  Epstein-Barr virus infection
ssyn05170  Human immunodeficiency virus 1 infection
ssyn05171  Coronavirus disease - COVID-19
ssyn05200  Pathways in cancer
ssyn05205  Proteoglycans in cancer
ssyn05206  MicroRNAs in cancer
ssyn05214  Glioma
ssyn05223  Non-small cell lung cancer
ssyn05225  Hepatocellular carcinoma
Module
ssyn_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
Enzymes [BR:ssyn01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129493473 (PLCG2)
Membrane trafficking [BR:ssyn04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129493473 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129493473 (PLCG2)
SSDB
Other DBs
NCBI-GeneID: 129493473
NCBI-ProteinID: XP_055155673
Position
11:127191234..127369250
AA seq 1265 aa
MSTIVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFFLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgtccaccatagtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctgtat
ggcactcagttcttcctcagcacgctcagcttggcagctgactctaaagaagatgctgtt
aattggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattcttgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctccgcg
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgataccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacatacctgttttcacgagaaaacagc
atctgggatgagaagtatgatgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtctcataatacgtacctcacaggtgaccagctgcggagcgagtca
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccacggctggacgcggaccaccaagatc
aaatttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccattgaggagcactgcagcgtggaacagcagcgtcacatggccaaggcc
ttcaaggaagtgtttggcgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaagtgccccaggat
ataccccccacagagctacattttggggagaaatggttccacaagaaggtagagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ctgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgtggagaggcagaggacatgctg
atgaggattccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cactttgtgctggggacctctgcctattttgagagcctagtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgatgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaacggtgaaggctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggcgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatttcaactgcagatgtcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtt
gtgaaagcccctcagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acaaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgactcgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagtac
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaggtggagatctgtggagccgagtatgacaacaacaagttcaag
acaacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acgtttgaaatttatgacccaaacctggcatttctgcgctttgtggtttacgaagaagac
atgttcagcgatcccaactttctcgcccatgccacttaccccattaaagcaatcaaatca
ggattcaggtctgttcctctgaagaatgggtacagcgaggacatagaactggcttccctc
ctggttttctgtgagatgcggccggtactggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacgcac
cagaacttgcgcaatgccaaccgggatgccctgattaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttattcatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (20)   
   RefSeq(pep) (20)   
DNA sequence (20)   
   RefSeq(nuc) (20)   
All databases (96)   

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