LOCUS       XP_047278523            1015 aa            linear   PRI 25-AUG-2024
DEFINITION  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
            delta isoform isoform X3 [Homo sapiens].
ACCESSION   XP_047278523
VERSION     XP_047278523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047422567.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     Protein         1..1015
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform X3"
                     /calculated_mol_wt=116136
     Region          34..107
                     /region_name="PI3K_p85B"
                     /note="PI3-kinase family, p85-binding domain; pfam02192"
                     /db_xref="CDD:460483"
     Region          175..261
                     /region_name="PI3K_rbd"
                     /note="PI3-kinase family, ras-binding domain; pfam00794"
                     /db_xref="CDD:395642"
     Region          285..452
                     /region_name="C2_PI3K_class_I_beta_delta"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); cd08693"
                     /db_xref="CDD:176075"
     Region          474..655
                     /region_name="PI3Ka"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); smart00145"
                     /db_xref="CDD:214537"
     Region          647..1013
                     /region_name="PI3Kc_IA_delta"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; cd05174"
                     /db_xref="CDD:270718"
     Site            order(723,725..727,729,731,748,750,753,784,796..799,804,
                     807,869,871,881..882)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270718"
     Site            order(791..792,893..894,896,898,964,967)
                     /site_type="other"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:270718"
     Site            838
                     /site_type="other"
                     /note="Ras binding site [polypeptide binding]"
                     /db_xref="CDD:270718"
     Site            861..869
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     Site            882..906
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270718"
     CDS             1..1015
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /coded_by="XM_047422567.1:966..4013"
                     /db_xref="GeneID:5293"
                     /db_xref="HGNC:HGNC:8977"
                     /db_xref="MIM:602839"
ORIGIN      
        1 mppgvdcpme fwtkeenqsv vvdfllptgv ylnfpvsrna nlstikqllw hraqyeplfh
       61 mlsgpeayvf tcinqtaeqq eledeqrrlc dvqpflpvlr lvaregdrvk klinsqisll
      121 igkglhefds lcdpevndfr akmcqfceea aarrqqlgwe awlqysfplq lepsaqtwgp
      181 gtlrlpnral lvnvkfegse esftfqvstk dvplalmaca lrkkatvfrq plveqpedyt
      241 lqvngrheyl ygsyplcqfq snpapqvqkp rakpppipak kpssvslwsl eqpfrieliq
      301 gskvnaderm klvvqaglfh gnemlcktvs ssevsvcsep vwkqrlefdi nicdlprmar
      361 lcfalyavie kakkarstkk kskkadcpia wanlmlfdyk dqlktgercl ymwpsvpdek
      421 gellnptgtv rsnpntdsaa alliclpeva phpvyypale kilelgrhse cvhvteeeql
      481 qlreilerrg sgelyehekd lvwklrhevq ehfpealarl llvtkwnkhe dvaqmlyllc
      541 swpelpvlsa lelldfsfpd chvgsfaiks lrkltddelf qyllqlvqvl kyesyldcel
      601 tkflldrala nrkighflfw hlrsemhvps valrfglile aycrgsthhm kvlmkqgeal
      661 sklkalndfv klssqktpkp qtkelmhlcm rqeayleals hlqspldpst llaevcveqc
      721 tfmdskmkpl wimysneeag sggsvgiifk ngddlrqdml tlqmiqlmdv lwkqegldlr
      781 mtpygclptg drtglievvl rsdtianiql nksnmaataa fnkdallnwl ksknpgeald
      841 raieeftlsc agycvatyvl gigdrhsdni miresgqlfh idfghflgnf ktkfginrer
      901 vpfiltydfv hviqqgktnn sekferfrgy ceraytilrr hgllflhlfa lmraaglpel
      961 scskdiqylk dslalgktee ealkhfrvkf nealreswkt kvnwlahnvs kdnrq
//