LOCUS       XP_047278521            1043 aa            linear   PRI 25-AUG-2024
DEFINITION  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
            delta isoform isoform X2 [Homo sapiens].
ACCESSION   XP_047278521
VERSION     XP_047278521.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047422565.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     Protein         1..1043
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform isoform X2"
                     /calculated_mol_wt=119221
     Region          34..107
                     /region_name="PI3K_p85B"
                     /note="PI3-kinase family, p85-binding domain; pfam02192"
                     /db_xref="CDD:460483"
     Region          175..281
                     /region_name="PI3K_rbd"
                     /note="PI3-kinase family, ras-binding domain; pfam00794"
                     /db_xref="CDD:395642"
     Region          314..481
                     /region_name="C2_PI3K_class_I_beta_delta"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); cd08693"
                     /db_xref="CDD:176075"
     Region          505..683
                     /region_name="PI3Ka"
                     /note="Phosphoinositide 3-kinase family, accessory domain
                     (PIK domain); smart00145"
                     /db_xref="CDD:214537"
     Region          675..1041
                     /region_name="PI3Kc_IA_delta"
                     /note="Catalytic domain of Class IA Phosphoinositide
                     3-kinase delta; cd05174"
                     /db_xref="CDD:270718"
     Site            order(751,753..755,757,759,776,778,781,812,824..827,832,
                     835,897,899,909..910)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270718"
     Site            order(819..820,921..922,924,926,992,995)
                     /site_type="other"
                     /note="putative regulatory subunit interface [polypeptide
                     binding]"
                     /db_xref="CDD:270718"
     Site            866
                     /site_type="other"
                     /note="Ras binding site [polypeptide binding]"
                     /db_xref="CDD:270718"
     Site            889..897
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270718"
     Site            910..934
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270718"
     CDS             1..1043
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /coded_by="XM_047422565.1:105..3236"
                     /db_xref="GeneID:5293"
                     /db_xref="HGNC:HGNC:8977"
                     /db_xref="MIM:602839"
ORIGIN      
        1 mppgvdcpme fwtkeenqsv vvdfllptgv ylnfpvsrna nlstikqllw hraqyeplfh
       61 mlsgpeayvf tcinqtaeqq eledeqrrlc dvqpflpvlr lvaregdrvk klinsqisll
      121 igkglhefds lcdpevndfr akmcqfceea aarrqqlgwe awlqysfplq lepsaqtwgp
      181 gtlrlpnral lvnvkfegse esftfqvstk dvplalmaca lrkkatvfrq plveqpedyt
      241 lqvngrheyl ygsyplcqfq yicsclhsgl tphltmvhss silamrdeqs npapqvqkpr
      301 akpppipakk pssvslwsle qpfrieliqg skvnadermk lvvqaglfhg nemlcktvss
      361 sevsvcsepv wkqrlefdin icdlprmarl cfalyaviek akkarstkkk skkadcpiaw
      421 anlmlfdykd qlktgercly mwpsvpdekg ellnptgtvr snpntdsaaa lliclpevap
      481 hpvyypalek ilelgrhsec vhvteeelql reilerrgsg elyehekdlv wklrhevqeh
      541 fpealarlll vtkwnkhedv aqmlyllcsw pelpvlsale lldfsfpdch vgsfaikslr
      601 kltddelfqy llqlvqvlky esyldceltk flldralanr kighflfwhl rsemhvpsva
      661 lrfglileay crgsthhmkv lmkqgealsk lkalndfvkl ssqktpkpqt kelmhlcmrq
      721 eaylealshl qspldpstll aevcveqctf mdskmkplwi mysneeagsg gsvgiifkng
      781 ddlrqdmltl qmiqlmdvlw kqegldlrmt pygclptgdr tglievvlrs dtianiqlnk
      841 snmaataafn kdallnwlks knpgealdra ieeftlscag ycvatyvlgi gdrhsdnimi
      901 resgqlfhid fghflgnfkt kfginrervp filtydfvhv iqqgktnnse kferfrgyce
      961 raytilrrhg llflhlfalm raaglpelsc skdiqylkds lalgkteeea lkhfrvkfne
     1021 alreswktkv nwlahnvskd nrq
//