LOCUS NP_001274319 516 aa linear PRI 22-SEP-2024
DEFINITION kynurenine--oxoglutarate transaminase 1 isoform c [Homo sapiens].
ACCESSION NP_001274319 XP_005252351
VERSION NP_001274319.1
DBSOURCE REFSEQ: accession NM_001287390.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 516)
AUTHORS Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
Warscheid,B.
TITLE Quantitative high-confidence human mitochondrial proteome and its
dynamics in cellular context
JOURNAL Cell Metab 33 (12), 2464-2483 (2021)
PUBMED 34800366
REFERENCE 2 (residues 1 to 516)
AUTHORS Udupa,S., Nguyen,S., Hoang,G., Nguyen,T., Quinones,A., Pham,K.,
Asaka,R., Nguyen,K., Zhang,C., Elgogary,A., Jung,J.G., Xu,Q.,
Fu,J., Thomas,A.G., Tsukamoto,T., Hanes,J., Slusher,B.S.,
Cooper,A.J.L. and Le,A.
TITLE Upregulation of the Glutaminase II Pathway Contributes to Glutamate
Production upon Glutaminase 1 Inhibition in Pancreatic Cancer
JOURNAL Proteomics 19 (21-22), e1800451 (2019)
PUBMED 31231915
REMARK GeneRIF: genetic suppression of glutamine transaminase K (GTK), a
key enzyme of the glutaminase II pathway, leads to the complete
inhibition of pancreatic tumorigenesis in vivo unveiling GTK as a
new metabolic target for cancer therapy
REFERENCE 3 (residues 1 to 516)
AUTHORS Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
and Yu,H.
TITLE An interactome perturbation framework prioritizes damaging missense
mutations for developmental disorders
JOURNAL Nat Genet 50 (7), 1032-1040 (2018)
PUBMED 29892012
REFERENCE 4 (residues 1 to 516)
AUTHORS Matysik-Wozniak,A., Junemann,A., Turski,W.A., Wnorowski,A.,
Jozwiak,K., Paduch,R., Okuno,E., Moneta-Wielgos,J.,
Choragiewicz,T., Maciejewski,R. and Rejdak,R.
TITLE The presence of kynurenine aminotransferases in the human cornea:
Evidence from bioinformatics analysis of gene expression and
immunohistochemical staining
JOURNAL Mol Vis 23, 364-371 (2017)
PUBMED 28706436
REMARK GeneRIF: Immunohistochemical analysis revealed the presence of KAT
I, II, and III in all examined corneal sections.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 516)
AUTHORS Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
Kastenmuller,G., Spector,T.D. and Soranzo,N.
CONSRTM Multiple Tissue Human Expression Resource (MuTHER) Consortium
TITLE An atlas of genetic influences on human blood metabolites
JOURNAL Nat Genet 46 (6), 543-550 (2014)
PUBMED 24816252
REFERENCE 6 (residues 1 to 516)
AUTHORS Iyer,R.A. and Anders,M.W.
TITLE Cysteine conjugate beta-lyase-dependent biotransformation of the
cysteine S-conjugates of the sevoflurane degradation product
compound A in human, nonhuman primate, and rat kidney cytosol and
mitochondria
JOURNAL Anesthesiology 85 (6), 1454-1461 (1996)
PUBMED 8968194
REFERENCE 7 (residues 1 to 516)
AUTHORS Goldfarb,P., Perry,S., Harries,H., Scholfield,C., Lock,T., King,L.
and Gibson,G.
TITLE Molecular cloning and expression of cDNAs for rat and human kidney
cysteine conjugate beta-lyase
JOURNAL Biochem Soc Trans 24 (2), 330S (1996)
PUBMED 8736988
REFERENCE 8 (residues 1 to 516)
AUTHORS Perry,S., Harries,H., Scholfield,C., Lock,T., King,L., Gibson,G.
and Goldfarb,P.
TITLE Molecular cloning and expression of a cDNA for human kidney
cysteine conjugate beta-lyase
JOURNAL FEBS Lett 360 (3), 277-280 (1995)
PUBMED 7883047
REFERENCE 9 (residues 1 to 516)
AUTHORS Baran,H., Okuno,E., Kido,R. and Schwarcz,R.
TITLE Purification and characterization of kynurenine aminotransferase I
from human brain
JOURNAL J Neurochem 62 (2), 730-738 (1994)
PUBMED 8294935
REFERENCE 10 (residues 1 to 516)
AUTHORS Lash,L.H., Nelson,R.M., Van Dyke,R.A. and Anders,M.W.
TITLE Purification and characterization of human kidney cytosolic
cysteine conjugate beta-lyase activity
JOURNAL Drug Metab Dispos 18 (1), 50-54 (1990)
PUBMED 2139845
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL672142.9 and AL441992.17.
On Dec 13, 2013 this sequence version replaced XP_005252351.1.
Summary: This gene encodes a cytosolic enzyme that is responsible
for the metabolism of cysteine conjugates of certain halogenated
alkenes and alkanes. This metabolism can form reactive metabolites
leading to nephrotoxicity and neurotoxicity. Increased levels of
this enzyme have been linked to schizophrenia. Multiple transcript
variants that encode different isoforms have been identified for
this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (4) differs in the 5' UTR and CDS,
and uses an alternate upstream translation start, compared to
variant 1. The resulting protein (isoform c) has a longer
N-terminus, compared to isoform a. Variants 4 and 12 both encode
the same isoform (c).
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK297995.1, SRR1660805.255148.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..516
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34.11"
Protein 1..516
/product="kynurenine--oxoglutarate transaminase 1 isoform
c"
/EC_number="2.6.1.64"
/EC_number="2.6.1.7"
/EC_number="4.4.1.13"
/note="glutamine-phenylpyruvate aminotransferase;
glutamine transaminase K; kyneurenine aminotransferase;
cysteine conjugate-beta lyase; cytoplasmic (glutamine
transaminase K, kyneurenine aminotransferase);
beta-lysase, kidney; kynurenine aminotransferase I;
kynurenine--oxoglutarate transaminase 1;
cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate
transaminase; kynurenine--oxoglutarate transaminase I;
cysteine conjugate-beta lyase, cytoplasmic; cysteine
conjugate beta lyase 1"
/calculated_mol_wt=57538
Region 101..512
/region_name="AspB"
/note="Aspartate/methionine/tyrosine aminotransferase
[Amino acid transport and metabolism]; COG0436"
/db_xref="CDD:440205"
CDS 1..516
/gene="KYAT1"
/gene_synonym="CCBL1; GTK; KAT1; KATI"
/coded_by="NM_001287390.3:170..1720"
/note="isoform c is encoded by transcript variant 4"
/db_xref="CCDS:CCDS75915.1"
/db_xref="GeneID:883"
/db_xref="HGNC:HGNC:1564"
/db_xref="MIM:600547"
ORIGIN
1 mfrtaaaisv hlvgplqgrk agapltwflh qtqvaeknvg spaprptshl glanpqerkv
61 pqgpqspcev paaegilrtg gaklpiqghp aklamakqlq arrldgidyn pwvefvklas
121 ehdvvnlgqg fpdfpppdfa veafqhavsg dfmlnqytkt fgyppltkil asffgellgq
181 eidplrnvlv tvggygalft afqalvdegd eviiiepffd cyepmtmmag grpvfvslkp
241 gpiqngelgs ssnwqldpme lagkftsrtk alvlntpnnp lgkvfsreel elvaslcqqh
301 dvvcitdevy qwmvydghqh isiaslpgmw ertltigsag ktfsatgwkv gwvlgpdhim
361 khlrtvhqns vfhcptqsqa avaesfereq llfrqpssyf vqfpqamqrc rdhmirslqs
421 vglkpiipqg syflitdisd fkrkmpdlpg avdepydrrf vkwmiknkgl vaipvsifys
481 vphqkhfdhy irfcfvkdea tlqamdeklr kwkvel
//