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KEGG   Panthera pardus (leopard): 109245637
Entry
109245637         CDS       T06062                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00562  Inositol phosphate metabolism
ppad01100  Metabolic pathways
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04020  Calcium signaling pathway
ppad04062  Chemokine signaling pathway
ppad04064  NF-kappa B signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04070  Phosphatidylinositol signaling system
ppad04072  Phospholipase D signaling pathway
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04380  Osteoclast differentiation
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04625  C-type lectin receptor signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04670  Leukocyte transendothelial migration
ppad04722  Neurotrophin signaling pathway
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04919  Thyroid hormone signaling pathway
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04935  Growth hormone synthesis, secretion and action
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05169  Epstein-Barr virus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05171  Coronavirus disease - COVID-19
ppad05200  Pathways in cancer
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05214  Glioma
ppad05223  Non-small cell lung cancer
ppad05225  Hepatocellular carcinoma
Module
ppad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109245637 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    109245637 (PLCG2)
   04064 NF-kappa B signaling pathway
    109245637 (PLCG2)
   04066 HIF-1 signaling pathway
    109245637 (PLCG2)
   04070 Phosphatidylinositol signaling system
    109245637 (PLCG2)
   04072 Phospholipase D signaling pathway
    109245637 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109245637 (PLCG2)
   04613 Neutrophil extracellular trap formation
    109245637 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    109245637 (PLCG2)
   04662 B cell receptor signaling pathway
    109245637 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    109245637 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    109245637 (PLCG2)
   04670 Leukocyte transendothelial migration
    109245637 (PLCG2)
   04062 Chemokine signaling pathway
    109245637 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    109245637 (PLCG2)
   04919 Thyroid hormone signaling pathway
    109245637 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    109245637 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109245637 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    109245637 (PLCG2)
   04380 Osteoclast differentiation
    109245637 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109245637 (PLCG2)
   05206 MicroRNAs in cancer
    109245637 (PLCG2)
   05205 Proteoglycans in cancer
    109245637 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    109245637 (PLCG2)
   05214 Glioma
    109245637 (PLCG2)
   05223 Non-small cell lung cancer
    109245637 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    109245637 (PLCG2)
   05171 Coronavirus disease - COVID-19
    109245637 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109245637 (PLCG2)
   05169 Epstein-Barr virus infection
    109245637 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109245637 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109245637 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109245637 (PLCG2)
Enzymes [BR:ppad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     109245637 (PLCG2)
Membrane trafficking [BR:ppad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    109245637 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    109245637 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 PH_14 SH3_2 GDPD
Other DBs
NCBI-GeneID: 109245637
NCBI-ProteinID: XP_019268617
Ensembl: ENSPPRG00000011326
UniProt: A0A9V1DVX2
Position
Unknown
AA seq 1265 aa
MTAMVNMDTLPEYEKSQIKRTLELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAARQKEDCCFTILYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSITLRELKTILPLVNFKVNSA
KFLKDKFVEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQEVWAQDLNKVRERMTKFIDDTLRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDIQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
TNAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSVMEGGTMKYF
LTDNIMFTSIYDLIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRNDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNQALFSLNGRTGYVLQPESMRTEKYDPMPPEAQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccgccatggtcaacatggacacccttcctgaatatgagaagagtcagatcaagaga
accctggagctgggcacggtgatgaccgtgttcagctttcgtaagtctacccccgagcgg
aggactgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggctgacaag
attgaaggcttcttggatatcatggaaatcaaggaaatccgccccgggaagaactccaag
gattttgagcgcgcgaaggcagcccgccagaaggaggactgctgtttcaccatcttgtac
ggcacccagttcgtcctgagcactctgagtttggcagctgattctaaagaagatgccact
aagtggctctctggcttgaaaatcttacaccaggaagcgatgagtgcctctacgcccacc
attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc
atcaccctccgggagctgaagaccatcttgcccctggtcaacttcaaagtgaacagtgcc
aagttcctcaaagataagtttgtggaaatcggcgctcacaaagatgaactcagctttgag
cagttccaccttttctataaaaatcttatgtttgagcagcaaaagtcgattcttgatgaa
ttcaaaaaagattcttccgtgttcatcttgggcaacaccgaccggccggatgcctccgct
gtttacctgcacgacttccagcggtttctcctacacgaacagcaggaggtttgggctcag
gatctgaacaaagtccgcgagcggatgacaaagtttatcgatgacaccctgagggagacc
gccgagcccttcttgtttgttgatgagttcctcacgtacctgttttcgcgggagaacagc
atctgggacgagaagtacgacgtcgtggacatacaggacatgaacaaccccttgtcccat
tactggatctcctcctcacataacacgtacctcaccggtgaccagctgcggagtgagtcg
tccacggaggcatacatccgctgcctgcgcatgggctgtcgctgcatcgagctggactgc
tgggacgggcccgatgggaagcccatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgacgtcgtgcaggccatcaaagaccatgcctttgtcacctcaagcttcccg
gtgatcctgtccatcgaagagcactgctgtgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgacctgctgttgacaaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgatgtggatgtcaacgtggaagataagaaagatgagcacaagcaacagggtgaa
ctgtacatgtgggattccattgaccagaaatggacccggcactactgtgccatcgctgat
gccaagctgtcgttcagcgatgacattgagcagactgcagaggaggagctgccccaggat
ataccccccacggagctgcattttggggaggagtggttccacaagaaggtggagaagaga
acaaatgccgagaagctgcttcaggaatactgtgccgagacggggggcaaagatgggacc
ttcttggtgcgggagagcaagaccttccccaacgactacaccctgtccttctggcggtcc
ggccgggtccagcactgccggatccgctccgtcatggagggcgggaccatgaagtacttc
ctgactgacaacatcatgttcaccagcatctatgacctcatccagcactaccgtgagacg
cacctgcgctgtgccgagttcgagctccggctcaccgaccccgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgatggcctgagccgcggggaagcagaggacatgctg
atgagagttccccgggacggggccttcctgatccggaggcgggaaggtaccgactcctac
gccatcaccttcagggccaggggcaaagtaaagcattgccgcatccatcgggacggccgg
cactttgtgctggggacctctgcctacttcgagagcctcgtcgagctggtcagttactac
gagaagcacgcgctctaccggaagatgcggctgcgctatcccgtgacgcctgagctgctg
gagcgctacaatatggaacgagatatcaactccctctatgacgtcagcaggatgtatgtg
gatcccagtgaaatcaacccgtccatgcctcagaggaccgtcaaagctctgtatgactac
aaagccaagcgaaacgatgagctgagcttctgccgtggggccctcattcacaacgtctcc
aaggagccctggggctggtggaaaggagactatgggaccaggatccagcaatactttcca
tccaactacgttgaggacatttcaacggtcgatgtggaagaactggaaaagcagattatt
gaagacaatcccttagggtctctttgcaggggaatactggatctcaacacctataacgtc
gtgaaagccccgcaggggaaaaaccagaaggcgttcgtgttcatcctggagcccaagaag
caaggcgaccctccggtggagtttgccacagacagggtcgaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatggacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtagtctactgcaagccgacc
agcaagaccaaggacaatttagaaaaccccgacttccgagaaatccgctccttcgtggag
acgaaggctgacagtgtcgtcagacagaaaccggtcgacctcctcaagtacaatcagaag
ggcctgacccgtgtctacccgaagggacagagggtggactcctccaactatgaccccttt
cgcctctggctgtgtggctcccagatggtggcactcaatttccagactccagacaagtac
atgcagatgaatcaagccttgttctcactcaacgggcggacaggctacgtcctgcagccc
gagagcatgaggacggagaagtacgaccccatgccgcccgaagcccagcggaagattttg
atgactctgacagtcaaggttctcggggctcgccatctccccaaacttggccgaagcatc
gcatgtccctttgtggaggtggaaatctgcggggctgaatatgacaacaacaagtttaag
accacagttgtgaatgacaatggcctaagccccgtttgggctccgacacaggagaaggtg
acctttgaaatttatgacccaaacctcgcgtttctgcgctttgtggtctacgaggaagat
atgttcagtgatcctaacttcctcgctcatgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagtgaagatatcgagctggcttccctc
ctggtgttctgtgagatgcagccagtcctggagagtgaagaggaactctactcctcctgc
cgccagctgcgaaggcggcaggaagagctgaacaaccagctgttcctgtacgacacgcac
cagaatctgcgcaatgccaaccgggatgccctcgtgaaagagttcaacgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagttagcaac
agtaggttttactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (14)   
   Pfam (14)   
All databases (75)   

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