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KEGG   Pteronotus mesoamericanus (Parnell's mustached bat): 129075160
Entry
129075160         CDS       T09558                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ppam  Pteronotus mesoamericanus (Parnell's mustached bat)
Pathway
ppam00562  Inositol phosphate metabolism
ppam01100  Metabolic pathways
ppam01521  EGFR tyrosine kinase inhibitor resistance
ppam04012  ErbB signaling pathway
ppam04014  Ras signaling pathway
ppam04020  Calcium signaling pathway
ppam04062  Chemokine signaling pathway
ppam04064  NF-kappa B signaling pathway
ppam04066  HIF-1 signaling pathway
ppam04070  Phosphatidylinositol signaling system
ppam04072  Phospholipase D signaling pathway
ppam04360  Axon guidance
ppam04370  VEGF signaling pathway
ppam04380  Osteoclast differentiation
ppam04611  Platelet activation
ppam04613  Neutrophil extracellular trap formation
ppam04625  C-type lectin receptor signaling pathway
ppam04650  Natural killer cell mediated cytotoxicity
ppam04662  B cell receptor signaling pathway
ppam04664  Fc epsilon RI signaling pathway
ppam04666  Fc gamma R-mediated phagocytosis
ppam04670  Leukocyte transendothelial migration
ppam04722  Neurotrophin signaling pathway
ppam04750  Inflammatory mediator regulation of TRP channels
ppam04919  Thyroid hormone signaling pathway
ppam04933  AGE-RAGE signaling pathway in diabetic complications
ppam04935  Growth hormone synthesis, secretion and action
ppam05167  Kaposi sarcoma-associated herpesvirus infection
ppam05169  Epstein-Barr virus infection
ppam05170  Human immunodeficiency virus 1 infection
ppam05171  Coronavirus disease - COVID-19
ppam05200  Pathways in cancer
ppam05205  Proteoglycans in cancer
ppam05206  MicroRNAs in cancer
ppam05214  Glioma
ppam05223  Non-small cell lung cancer
ppam05225  Hepatocellular carcinoma
Module
ppam_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ppam00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129075160 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    129075160 (PLCG2)
   04064 NF-kappa B signaling pathway
    129075160 (PLCG2)
   04066 HIF-1 signaling pathway
    129075160 (PLCG2)
   04070 Phosphatidylinositol signaling system
    129075160 (PLCG2)
   04072 Phospholipase D signaling pathway
    129075160 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129075160 (PLCG2)
   04613 Neutrophil extracellular trap formation
    129075160 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    129075160 (PLCG2)
   04662 B cell receptor signaling pathway
    129075160 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    129075160 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    129075160 (PLCG2)
   04670 Leukocyte transendothelial migration
    129075160 (PLCG2)
   04062 Chemokine signaling pathway
    129075160 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    129075160 (PLCG2)
   04919 Thyroid hormone signaling pathway
    129075160 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    129075160 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129075160 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    129075160 (PLCG2)
   04380 Osteoclast differentiation
    129075160 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129075160 (PLCG2)
   05206 MicroRNAs in cancer
    129075160 (PLCG2)
   05205 Proteoglycans in cancer
    129075160 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    129075160 (PLCG2)
   05214 Glioma
    129075160 (PLCG2)
   05223 Non-small cell lung cancer
    129075160 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    129075160 (PLCG2)
   05171 Coronavirus disease - COVID-19
    129075160 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129075160 (PLCG2)
   05169 Epstein-Barr virus infection
    129075160 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    129075160 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129075160 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppam04131]
    129075160 (PLCG2)
Enzymes [BR:ppam01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     129075160 (PLCG2)
Membrane trafficking [BR:ppam04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    129075160 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    129075160 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 129075160
NCBI-ProteinID: XP_054435110
Position
Unknown
AA seq 1265 aa
MTAMVNVDALQEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIVEIKEIRPGKNSKDFERAKVVRQKEDCCFTILYGTQFTLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQEHWAQDLNKVRKRMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCGVEQQRYMARV
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDIDVDMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEELPQDTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCSETGGKDGTFLVRESERFPNDYTLSFWRSGRVQHCRIRSTMEDGVLRYY
LTDNLTFPSIYDLIQHYRGTHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGSDSYAITFRAKGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
RKHALYRKMKLRYPVTPELLERYSMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTVDVEDLEKQII
EDNPLGSLCRGILDLNAYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIRQITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVIRQKPIDLLKYNQKALTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNQALFSLNGRTGYVLQPESMRTEKYDPLPLESQRKIQMTLTVKVLGARHLPKPGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWASTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccgccatggtcaatgtggacgcccttcaggaatatgagaagagtcagatcaaaaga
gccttggagctgggcacggtgatgactgtgttcagcttccgcaagtccaccccggagcgc
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagtaagacagccgacaag
atcgaaggcttcttggatatcgtggaaataaaggaaatccgcccagggaagaactctaag
gattttgagcgtgctaaagtagtccgccagaaggaagactgctgcttcaccatcttgtat
ggcacccagttcaccctcagcacactcagtttagcagcggactctaaggaagatgcaacc
aagtggctctctggcttgaaaatcttacaccaagaagcaatgagcgcatccacacccacc
attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc
atcagcctccgagagttgaaggccatcttgcccctcgtcaacttcaaagtgagcagtgcc
aagttcctcaaggataagtttgtggaaataggcgcgcacaaagatgaactcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattcttgatgaa
ttcaaaaaagactcctctgtgttcatcctgggcaacactgaccggccggacgcctctgct
gttcacctgcacgacttccagcggtttctcttacatgaacagcaggaacattgggctcag
gatctgaacaaagtccgcaagaggatgacaaagtttatcgatgacacgatgagggaaact
gcggagcccttcttgtttgtcgatgagttcctcacatacctgttttcacgggagaacagc
atttgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtcccat
tactggatctcctcatcacataacacgtacctcacaggtgaccagctgcggagtgagtca
tccacggaggcatatatccgctgtctgcgcatgggctgtcgctgcattgagttggactgc
tgggacgggcccgacgggaagcccatcatctaccatggctggacacggaccaccaagatc
aagtttgatgatgttgtgcaggccatcaaagaccatgcctttgtcacctcgagcttccct
gtgatcctgtccatcgaggagcactgcggcgtggaacagcagcgctacatggccagagtg
tttaaggaggtgtttggcgacctgctgctgatgaagcccacggaggccagtgccgaccag
ctgccctcgcccagccagttgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacatcgacgtcgacatggaggacaagaaggacgaacacaagcagcagggcgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccatcgccgat
gccaagttgtccttcagcgatgacattgaacagaccatggaagaggaactgccccaggat
acgcccccaacagagctgcattttggagagaagtggttccataagaaggtagagaagagg
acaagtgctgagaagctgttgcaggagtactgctctgagacagggggcaaggatggaacc
ttcttggtgcgggagagcgagagattccccaatgactacaccctgtccttctggcggtct
ggccgggtccagcactgccggatccgctctaccatggaggacggggtgctgcggtactac
ctgactgacaacctcacgttccccagcatctacgacctcatccagcactaccgtgggacg
cacctgcgctgcgccgagttcgagctccggctcaccgaccccgtgcccaaccccaacccc
cacgaatcaaagccgtggtactatgacgggctgagccgtggagaagcagaggacatgctc
atgagagttccccgggacggcgccttcctcatccggaagcgggaaggcagcgactcctac
gccatcaccttcagggccaagggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cactttgtgctggggacctctgcctactttgagagtctggtggagctcgtcagttactac
aggaagcacgcgctgtaccgaaagatgaaactgcgctaccctgtgactcccgaactcctg
gagcgctacagtatggaaagagatataaactccctgtatgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccttctatgcctcagagaactgtgaaagctctatatgactac
aaagccaagcagagtgacgagctgagcttctgccgtggcgccctcattcacaacgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccagaatccagcagtatttccca
tccaattacgttgaagacatttcaacagttgatgtggaggatctggaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatactggatctcaatgcctataacgtt
gtgaaagcgccacagggcaaaaaccagaagccttttgtctttatcctggagcccaagaag
cagggtgaccctccagtggagtttgccacggacagggtggaggagctctttgaatggttt
cagagcatccggcagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtcgatcgccatcgagctctcagacctggtcgtctactgcaaaccaacc
agcaagaccaaagacaacttagaaaatcccgacttccgagaaatccgttcctttgtggag
acgaaggctgacagcgtcatcagacagaaacccatcgatctcctgaagtacaatcagaaa
gccctgacccgtgtttacccaaaggggcagagggtggactcctccaactacgatcccttc
cgcctctggctgtgcggctcccaaatggtggcactcaatttccagactgcagacaaatac
atgcagatgaatcaggccttgttctccctcaatgggaggaccggctacgtcctacagccc
gagagcatgaggacggagaagtacgaccccctgccactcgagtcccagaggaagattcag
atgaccctgacggtcaaggttctcggggctcgccatcttcccaagcctggacgaagcatt
gcgtgtccctttgtggaggtagaaatatgtggagccgaatatgacaataacaagtttaag
acaacggttgtgaatgacaatggcctaagccctgtttgggcttcgacacaggagaaggtg
acttttgaaatctatgatccaaacctcgcatttctgcgctttgtggtgtatgaggaagat
atgttcagcgatcccaactttctcgctcatgctacttaccccattaaaggaatcaaatca
ggatttagatctgttcctctgaagaatgggtacagcgaagacatcgagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactgtactcctcctgt
cgccagctgcggaggcggcaagaagagctgaacaaccagctctttctatatgacacacac
cagaacttgcgcaatgccaaccgggatgccctcattaaagagttcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttgagagagaagagagtcagcaac
agcaagttttactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (15)   
   Pfam (15)   
All databases (74)   

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