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KEGG   Pongo abelii (Sumatran orangutan): 100453904
Entry
100453904         CDS       T01416                                 
Symbol
CACNA1D
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1D isoform X5
  KO
K04851  voltage-dependent calcium channel L type alpha-1D
Organism
pon  Pongo abelii (Sumatran orangutan)
Pathway
pon04010  MAPK signaling pathway
pon04020  Calcium signaling pathway
pon04022  cGMP-PKG signaling pathway
pon04024  cAMP signaling pathway
pon04218  Cellular senescence
pon04260  Cardiac muscle contraction
pon04261  Adrenergic signaling in cardiomyocytes
pon04270  Vascular smooth muscle contraction
pon04530  Tight junction
pon04713  Circadian entrainment
pon04723  Retrograde endocannabinoid signaling
pon04724  Glutamatergic synapse
pon04725  Cholinergic synapse
pon04726  Serotonergic synapse
pon04727  GABAergic synapse
pon04728  Dopaminergic synapse
pon04911  Insulin secretion
pon04912  GnRH signaling pathway
pon04921  Oxytocin signaling pathway
pon04924  Renin secretion
pon04925  Aldosterone synthesis and secretion
pon04927  Cortisol synthesis and secretion
pon04929  GnRH secretion
pon04930  Type II diabetes mellitus
pon04934  Cushing syndrome
pon04935  Growth hormone synthesis, secretion and action
pon04973  Carbohydrate digestion and absorption
pon05010  Alzheimer disease
pon05020  Prion disease
pon05022  Pathways of neurodegeneration - multiple diseases
pon05031  Amphetamine addiction
pon05207  Chemical carcinogenesis - receptor activation
pon05410  Hypertrophic cardiomyopathy
pon05412  Arrhythmogenic right ventricular cardiomyopathy
pon05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:pon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    100453904 (CACNA1D)
   04022 cGMP-PKG signaling pathway
    100453904 (CACNA1D)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    100453904 (CACNA1D)
   04929 GnRH secretion
    100453904 (CACNA1D)
   04921 Oxytocin signaling pathway
    100453904 (CACNA1D)
   04935 Growth hormone synthesis, secretion and action
    100453904 (CACNA1D)
   04924 Renin secretion
    100453904 (CACNA1D)
   04925 Aldosterone synthesis and secretion
    100453904 (CACNA1D)
   04927 Cortisol synthesis and secretion
    100453904 (CACNA1D)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100453904 (CACNA1D)
  09156 Nervous system
   04724 Glutamatergic synapse
    100453904 (CACNA1D)
   04727 GABAergic synapse
    100453904 (CACNA1D)
   04725 Cholinergic synapse
    100453904 (CACNA1D)
   04728 Dopaminergic synapse
    100453904 (CACNA1D)
   04726 Serotonergic synapse
    100453904 (CACNA1D)
   04723 Retrograde endocannabinoid signaling
    100453904 (CACNA1D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100453904 (CACNA1D)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    100453904 (CACNA1D)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100453904 (CACNA1D)
   05020 Prion disease
    100453904 (CACNA1D)
   05022 Pathways of neurodegeneration - multiple diseases
    100453904 (CACNA1D)
  09165 Substance dependence
   05031 Amphetamine addiction
    100453904 (CACNA1D)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    100453904 (CACNA1D)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    100453904 (CACNA1D)
   05414 Dilated cardiomyopathy
    100453904 (CACNA1D)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100453904 (CACNA1D)
   04934 Cushing syndrome
    100453904 (CACNA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:pon04040]
    100453904 (CACNA1D)
Ion channels [BR:pon04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   100453904 (CACNA1D)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 100453904
NCBI-ProteinID: XP_024100485
Ensembl: ENSPPYG00000013787
Position
2:complement(100529652..100865494)
AA seq 2137 aa
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTI
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDM
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVA
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
PKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEG
IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQA
VLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLI
INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP
LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA
VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN
TTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNS
DRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTN
ANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRSDSGDEQLPTIC
REDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDFERPRGY
HHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPLSPIFP
HRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVE
QSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEA
VLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSH
RQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL
NT seq 6414 nt   +upstreamnt  +downstreamnt
atgatgatgatgatgatgatgaaaaaaatgcagcatcaacggcagcagcaagcggaccac
gcgaacgaggcaaactatgcaagaggcaccagactccctctttctggtgaaggaccaact
tctcagccgaatagctccaagcaaactgtcctgtcttggcaagctgcaatcgatgctgct
agacaggccaaggctgcccaaactatgagcacctctgcacccccacctgtaggatctctc
tcccaaagaaaacgtcagcaatacgccaagagcaaaaaacagggtaactcgtccaacagc
cgacctgcccgcgcccttttctgtttatcactcaataaccccatccgaagagcctgcatt
agtatagtggaatggaaaccatttgacatatttatattattggctatttttgccaattgt
gtggccttagctatttacatcccattccctgaagatgattctaattcaacaaatcataac
ttggaaaaagtagaatatgccttcctgattatttttacagttgagacatttttgaagatt
atagcttatggattattgctacatcctaatgcttatgttaggaatggatggaatttactg
gattttgttatagtaatagtaggattgtttagtgtaattttggaacaattaaccaaagaa
acagaaggcgggaaccactctagcggcaaatctggaggctttgatgtcaaagccctccgt
gcctttcgagtgttgcgaccacttcgactagtgtcaggagtgcccagtttacaagttgtc
ctgaactccattataaaagccatggttcccctccttcacatagcccttttggtattattt
gtaatcataatctatgctattataggattggaactttttattggaaaaatgcacaaaaca
tgtttttttgctgactcagatatcgtagctgaagaggacccagctccatgtgcgttctca
gggaatggacgccagtgtactgccaatggcacagaatgtaggagtggctgggttggcccg
aacggaggcatcaccaattttgataactttgcctttgccatgctcactgtgtttcagtgc
atcaccatggagggctggacagacgtgctctactggatgaatgatgctatgggatttgaa
ttgccctgggtgtattttgtcagtctcgtcatctttgggtcatttttcgtactaaatctt
gtacttggtgtattgagcggagaattctcaaaggaaagagagaaggcaaaagcgcgggga
gatttccagaagctccgggagaagcagcagctggaggaggatctaaagggctacttggat
tggatcacccaagctgaggacatcgatcctgagaacgaggaagaaggaggagaggaaggc
aaacgaaatactagcatgcccaccagcgagactgagtctgtgaacacagagaacgtcagc
ggcgaaggcgagaaccgaggctgctgtggaagtctctgtcaagccatctcaaaatccaaa
ctcagccgacgctggcgtcgctggaaccgattcaatcgcagaagatgtagggctgccgtg
aagtctgtcacgttttactggctggttatcgtcctggtgtttctgaacaccttaaccatt
tcctctgagcactacaatcagccagattggttgacacagattcaagatattgccaacaaa
gtcctcttggctctgttcacctgcgagatgctggtaaaaatgtacagcttgggcctccaa
gcatatttcgtctctcttttcaaccggtttgattgcttcgtggtgtgtggtggaatcact
gagacgatcttggtggaactggaaatcatgtctcccctggggatctctgtgtttcggtgt
gtgcgcctcttaagaatcttcaaagtgaccaggcactggacttccctgagcaacttagtg
gcatccttgttaaactccatgaagtccatcgcttcgctgttgcttctgctttttctcttc
attatcatcttttccttgcttgggatgcagctgtttggcggcaagtttaattttgatgaa
acgcaaaccaagcggagcacctttgacaatttccctcaagcacttctcacagtgttccag
atcctgacaggtgaagactggaacgctgtgatgtacgatggcatcatggcttacgggggc
ccgtcctcttcaggaatgattgtctgcatctacttcatcatcctcttcatttgtggtaac
tatattctactgaatgtcttcttggccatcgctgtagacaatttggctgatgctgaaagt
ttgaacactgctcagaaagaagaagcggaagaaaaggagaggaaaaagattgcaagaaaa
gagagcctagaaaataaaaagaacaacaaaccagaagtcaaccagatagccaacagtgac
aacaaggttacaattgatgactatagagaagaggatgaagacaaggacccctacccgcct
tgcgatgtgccagtaggggaagaggaagaggaagaggaggaggatgaacctgaggttcct
gccggaccccgtcctcgaaggatctcggagttgaacatgaaggaaaaaattgcccccatc
cctgaagggagcgctttcttcattcttagcaagaccaacccgatccgcgtaggctgccac
aagctcatcaaccaccacatcttcaccaacctcatcctcgtcttcatcatgctgagcagc
gctgccctggccgcagaggaccccatccgcagccactccttccggaacacaatactgggt
tactttgactatgccttcacagccatctttactgttgagatcctgttgaagatgacaact
tttggagctttcctccacaaaggggccttctgcaggaactacttcaatttgctggatatg
ctggtggttggggtgtctctggtgtcatttgggattcaatccagtgccatctccgttgtg
aagattctgagggtcttaagggtcctgcggcccctcagggccatcaacagagcaaaagga
cttaagcacgtggtccagtgcgtcttcgtggccatccggaccatcggcaacatcatgatc
gtcaccaccctcctccagttcatgtttgcctgtatcggggtccagttgttcaaggggaag
ttttatcgctgtacagatgaagccaaaagtaaccctgaagaatgcaggggacttttcatc
ctctacaaggatggggatgttgacagtcctgtggtccgtgagcggatctggcaaaacagt
gatttcaacttcgacaacgtcctctctgctatgatggcgctcttcacggtctccacattt
gagggctggcctgcgttgctgtataaagccatcgactcgaatggagagaacatcggccca
atctacaaccaccgcgtggagatctccatcttcttcatcatctacatcatcattgtagct
ttcttcatgatgaacatctttgtgggctttgtcatcgttacatttcaggagcaaggagaa
aaagagtataagaactgtgagctggacaaaaatcagcgtcagtgtgttgaatacgccttg
aaagcacgtcccttgcggagatacatccccaaaaacccctaccagtacaagttctggtac
gtggtgaactcttcgcctttcgaatacatgatgtttgtcctcatcatgctcaacacactc
tgcttggccatgcagcactacgagcagtccaagatgttcaatgatgccatggacattctg
aacatggtcttcactggggtgttcaccgtcgagatggttttgaaagtcatcgcatttaag
cctaaggggtattttagtgacgcctggaacacgtttgactccctcatcgtaatcggcagc
attatagacgtggccctcagcgaagcagacaactctgaagagagcaatagaatctccatc
acctttttccgtcttttccgagtgatgcgattggtgaagcttctcagcaggggggaaggc
atccggacattgctgtggacttttattaagtcttttcaggcgctcccgtatgtggccctc
ctcatagccatgctgttcttcatctatgcggtcattggcatgcagatgtttgggaaagtt
gccatgagagataacaaccagatcaataggaacaataacttccagacgtttccccaggcg
gtgctgctgctcttcaggtgtgcgacaggtgaggcctggcaggagatcatgctggcctgt
ctccctgggaaactctgtgaccctgagtcagattacaatcccggggaggagtatacatgt
ggaagcaactttgccattgtctatttcatcagtttttacatgctctgtgcgtttctgatc
atcaatctgtttgtggctgtcatcatggataatttcgactatctgacccgggactggtct
attttggggcctcaccatttagatgaattcaaaagaatatggtcagaatatgaccctgag
gcaaagggaaggataaaacaccttgacgtggtcactctgcttcgacgcatccagcctccc
ctggggtttgggaagttatgtccacacagagtagcgtgcaagagattagttgccatgaac
atgcctctcaacagtgatgggacagtcatgtttaatgcaaccctgtttgctttggttcga
acggctcttaagatcaagaccgaagggaacctggagcaagctaatgaagaacttcgggct
gtgataaagaaaatttggaagaaaaccagcatgaaattacttgaccaagttgtccctcca
gctggtgatgatgaggtaaccgtggggaagttctatgccactttcctgatacaggactac
tttaggaaattcaagaaacggaaagaacaaggactggtgggaaagtaccctgcgaagaac
accacaattgccctacaggcgggattaaggacactgcatgacattgggccagaaatccgg
cgtgctatatcgtgtgatttgcaagatgacgagcctgaggaaacaaaacgagaagaagaa
gatgatgtgttcaaaagaaatggtgccctgcttggaaaccatgtcaatcatgttaatagt
gataggagagattcccttcagcagaccaataccacccaccgtcccctgcatgtccaaagg
ccttcaattccacctgcaagtgatactgagaaaccgctgtttcctccagcaggaaattcg
gtgtgtcataaccatcataaccataattccataggaaagcaagttcccacctcaacaaat
gccaatctcaataatgccaatatgtccaaagctgcccatggaaagcggcccagcattggg
aaccttgagcatgtgtctgaaaatgggcatcattcttcccacaagcatgaccgggagcct
cagagaaggtccagtgtgaaaaggtccgactcaggagatgaacagctcccaactatttgc
cgggaagacccagagatacatggctatttcagggacccccactgcttgggggagcaggag
tatttcagtagtgaggaatgctacgaggacgacagctcgcccacctggagcaggcaaaac
tatggctactacagcagatacccaggcagaaacatcgactttgagaggccccgaggctac
catcaccctcaaggattcttggaggacgatgactcgcccgtttgctatgattcacggaga
tctccaaggagacgcctactacctcccaccccagcatcccaccggagatcctccttcaac
tttgagtgcctgcgccggcagagcagccaggaagaggtcccgctgtctcccatcttcccc
caccgcacggccctgcctctgcatctgatgcagcaacagatcatggcagttgccggccta
gattcaagtaaagcccagaagtactcaccgagtcactcgacccggtcgtgggccacccct
ccagcaacccctccctaccgggactggacaccgtgctatacccccctgatccaagtggag
cagtcagaggccctggaccaggtgaacggcagcctgccgtctctgcaccgcagctcctgg
tacacagacgagcccgacatctcctaccggactttcacaccagccagcctgaccgtcccc
agcagcttccggaacaaaaacagcgacaagcagaggagcgcggacagcttggtggaggca
gtcctgatatccgaaggcttgggacgctatgcaagggacccaaaatttgtgtcagcaaca
aaacacgaaatcgctgatgcctgtgacctcaccatcgacgagatggagagtgcagccagc
accctgcttaatgggaacgtgcgtccccgagccaacggggatgtgggccccctctcacat
cggcaggactatgagctacaggactttggtcctggctacagcgacgaagagccagaccct
gggagggatgaggaggacctggcagatgaaatgatatgcatcaccaccttgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (35)   
   KEGG PATHWAY (35)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (5)   
   Pfam (5)   
All databases (60)   

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