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KEGG   Phyllostomus hastatus (greater spear-nosed bat): 123805718
Entry
123805718         CDS       T07912                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
phas  Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas00562  Inositol phosphate metabolism
phas01100  Metabolic pathways
phas01521  EGFR tyrosine kinase inhibitor resistance
phas04012  ErbB signaling pathway
phas04014  Ras signaling pathway
phas04020  Calcium signaling pathway
phas04062  Chemokine signaling pathway
phas04064  NF-kappa B signaling pathway
phas04066  HIF-1 signaling pathway
phas04070  Phosphatidylinositol signaling system
phas04072  Phospholipase D signaling pathway
phas04360  Axon guidance
phas04370  VEGF signaling pathway
phas04380  Osteoclast differentiation
phas04611  Platelet activation
phas04613  Neutrophil extracellular trap formation
phas04625  C-type lectin receptor signaling pathway
phas04650  Natural killer cell mediated cytotoxicity
phas04662  B cell receptor signaling pathway
phas04664  Fc epsilon RI signaling pathway
phas04666  Fc gamma R-mediated phagocytosis
phas04670  Leukocyte transendothelial migration
phas04722  Neurotrophin signaling pathway
phas04750  Inflammatory mediator regulation of TRP channels
phas04919  Thyroid hormone signaling pathway
phas04933  AGE-RAGE signaling pathway in diabetic complications
phas04935  Growth hormone synthesis, secretion and action
phas05167  Kaposi sarcoma-associated herpesvirus infection
phas05169  Epstein-Barr virus infection
phas05170  Human immunodeficiency virus 1 infection
phas05171  Coronavirus disease - COVID-19
phas05200  Pathways in cancer
phas05205  Proteoglycans in cancer
phas05206  MicroRNAs in cancer
phas05214  Glioma
phas05223  Non-small cell lung cancer
phas05225  Hepatocellular carcinoma
Module
phas_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:phas00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123805718 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    123805718 (PLCG2)
   04064 NF-kappa B signaling pathway
    123805718 (PLCG2)
   04066 HIF-1 signaling pathway
    123805718 (PLCG2)
   04070 Phosphatidylinositol signaling system
    123805718 (PLCG2)
   04072 Phospholipase D signaling pathway
    123805718 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123805718 (PLCG2)
   04613 Neutrophil extracellular trap formation
    123805718 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    123805718 (PLCG2)
   04662 B cell receptor signaling pathway
    123805718 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    123805718 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    123805718 (PLCG2)
   04670 Leukocyte transendothelial migration
    123805718 (PLCG2)
   04062 Chemokine signaling pathway
    123805718 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    123805718 (PLCG2)
   04919 Thyroid hormone signaling pathway
    123805718 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    123805718 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123805718 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    123805718 (PLCG2)
   04380 Osteoclast differentiation
    123805718 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123805718 (PLCG2)
   05206 MicroRNAs in cancer
    123805718 (PLCG2)
   05205 Proteoglycans in cancer
    123805718 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    123805718 (PLCG2)
   05214 Glioma
    123805718 (PLCG2)
   05223 Non-small cell lung cancer
    123805718 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123805718 (PLCG2)
   05171 Coronavirus disease - COVID-19
    123805718 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123805718 (PLCG2)
   05169 Epstein-Barr virus infection
    123805718 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123805718 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123805718 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:phas04131]
    123805718 (PLCG2)
Enzymes [BR:phas01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123805718 (PLCG2)
Membrane trafficking [BR:phas04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123805718 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123805718 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 PH_14 SH3_2 Adhesin_E GDPD EF-hand_like
Other DBs
NCBI-GeneID: 123805718
NCBI-ProteinID: XP_045674372
Position
Unknown
AA seq 1265 aa
MTTMVNVDGLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKCSKDFERAKAVRQKEDCCFTILYGTQFTLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRKNSISLRELKTVLPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNRVRKRMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVVLSIEEHCGVEQQRYMARV
FKEVFGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVDMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCSEMGGKDGTFLVRESERFPNDYTLSFWRSGRVQHCRIRSTMEDGVMKYY
LTDNLMFPSIYALIQYYRGTHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGSDSYAITFRAKGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
KKHALYRKMKLRYPVTPELLERYSMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFYRGALIHNVSKEPGGWWKGDYGTKIQQYFPSNYVEDISSADVEDLEKQII
EDNPLGSLCRGILDLNAYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIRQITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKALTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNQALFSLNGRTGYVLQPESMRTDKYDPMPPESQRKIQMTLTVKVLGARHLPKPGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccaccatggtcaatgtggacggccttccggagtatgagaagagtcagatcaagaga
gccctggagctgggcacagtgatgaccgtgttcagcttccgcaagtccaccccggagcgc
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagtaagacggccgacaag
atcgaaggtttcttggatatcatggaaataaaggaaatccgcccggggaagtgctccaag
gattttgagcgtgcaaaagcagtgcgccagaaggaagactgctgcttcaccatcctgtac
ggcacccagttcaccctcagcacactcagtttagcagctgactctaaggaagatgcaacc
aagtggctctccggcttgaaaatcttacaccaagaagcaatgagtgcgtccacacccacc
attattgagagttggctgagaaagcagatttattcagtggaccaaaccagaaaaaacagc
atcagcctccgagagctgaagaccgtcttgcccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaggacaagtttgtggaaataggcgcgcacaaagacgaactcagctttgag
cagttccatctcttctataaaaaactaatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaagactcctccgtgttcatcttggggaacactgaccggccggacgcctctgct
gttcacctgcacgacttccagcggtttctcttacatgaacagcaggagctctgggctcag
gatctgaacagagtccgcaagaggatgacaaagtttatcgacgacacaatgagggaaact
gcggagccctttctgttcgttgatgagttcctcacgtacctgttttcacgggagaacagc
atttgggatgagaagtatgatgtggtggacatgcaggacatgaacaaccccttgtctcat
tactggatctcctcatcacataacacgtacctcacaggtgaccagctgcggagtgagtcg
tccacggaggcatacatccgctgtctgcgcatgggctgtcgctgcattgagttggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccacgcctttgtcacctcgagcttccct
gtggtcctgtccatcgaggagcactgtggcgtggaacagcagcgctacatggccagagtg
ttcaaggaggtgtttggtgacatgctgctgacgaagcccacggaggccagtgccgaccag
ctgccctcacccagccagctgcgggaaaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcgacatggaggacaagaaagatgagcacaagcaacagggtgaa
ctgtacatgtgggactccatcgaccagaaatggactcggcactattgcgccatcgccgat
gccaagctgtccttcagcgatgacattgaacagaccatggaagaagaagtgccccaggat
acaccccctaccgagctgcattttggagagaagtggttccacaagaaggtggagaagagg
acgagtgccgagaagctgctgcaggagtactgctccgagatggggggcaaggacgggacc
ttcttggtgcgggagagcgagaggttccccaatgactacaccctgtccttctggcggtca
ggccgcgtccagcactgccggatccgctccaccatggaggacggggtcatgaagtactac
ctgactgacaacctcatgttccccagcatctacgccctcatccagtactaccgcgggacg
cacctgcgctgtgccgagttcgagctgcgcctcacggaccctgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgacgggctgagccgtggagaagcggaggacatgctg
atgagagttccccgggacggtgccttcctcatccggaagcgggaaggcagcgactcctat
gccatcaccttcagggccaagggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cacttcgtgctggggacctccgcctacttcgagagcctggtggagctcgtcagttactac
aagaagcacgcgctgtaccggaagatgaaactgcgctaccccgtgactcccgaactcctg
gagcgctacagcatggaaagagacataaactccctgtatgacgtcagcagaatgtatgtg
gaccccagcgaaatcaatccttctatgcctcagagaactgtgaaagctctgtatgactac
aaagccaagcagagtgatgagctgagcttctaccgtggcgccctcattcacaacgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaaaatccagcagtacttcccg
tccaattacgtcgaggacatttcatcggctgatgtggaggatctggagaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatactggatctcaatgcctataatgtt
gtgaaagccccacagggcaaaaaccagaagcctttcgtctttatcctggaacccaagaag
cagggggaccctccggtggagtttgccacagacagggtggaggagctcttcgaatggttc
cagagcatccggcagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtcgatcgccatcgagctgtcagacctggtcgtctactgcaagccaacc
agcaagaccaaagacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcgtcgtcaggcagaagcccatcgatctcctgaagtacaatcagaag
gccctgacccgcgtgtacccgaagggacagagggtggactcctccaactacgatcccttc
cgcctctggctgtgtggctcccaaatggtggcactcaatttccagactgcagacaagtac
atgcagatgaatcaggccttgttctcgctcaatgggaggaccggctacgtcctacagcct
gagagcatgaggacggataagtatgaccccatgccacccgagtcccagaggaagattcag
atgaccttgacggtcaaggttctcggggctcgccatcttcccaagcctggacgaagcatc
gcatgtccctttgtggaggtggaaatatgtggagctgaatatgacaacaacaagtttaag
acgacggttgtgaatgacaatggcctaagccccgtttgggctccaacacaggagaaggtg
acattcgaaatttatgatccaaacctcgcgttcctgcgctttgtggtgtacgaggaagat
atgttcagcgatcccaactttcttgctcatgccacttaccctattaaaggaatcaaatca
ggatttagatctgttcctctgaagaatgggtacagcgaagacattgagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactctactcctcctgt
cgccagctgcggaggcggcaagaagagctgaacaaccagctctttctctacgacacacac
cagaacttgcgcaatgccaaccgggatgccctcattaaagaattcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (16)   
   Pfam (16)   
All databases (75)   

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