#=GF ID   Pap_E4
#=GF AC   PF02711.19
#=GF DE   E4 protein
#=GF AU   Mian N;0000-0003-4284-4749
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1589 (release 5.5)
#=GF GA   27.00 27.00;
#=GF TC   43.60 40.60;
#=GF NC   26.70 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 81514348 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9454695
#=GF RT   Identification of conserved hydrophobic C-terminal residues of
#=GF RT   the human papillomavirus type 1 E1E4 protein necessary for E4
#=GF RT   oligomerisation in vivo. 
#=GF RA   Ashmole I, Gallimore PH, Roberts S; 
#=GF RL   Virology 1998;240:221-231.
#=GF DR   INTERPRO; IPR003861;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is is a family of Papillomavirus proteins, E4, coded for by
#=GF CC    ORF4. A splice variant, E1--E4, exists but neither the function
#=GF CC   of E4 or E1--E4 is known [1].
#=GF SQ   44
#=GS A0A386JT18_9PAPI/4-93    AC A0A386JT18.1
#=GS VE4_HPV28/3-97           AC P51896.2
#=GS Q6LCS2_HPV44/46-144      AC Q6LCS2.1
#=GS Q9JH47_HPV69/6-101       AC Q9JH47.1
#=GS Q6LCV5_HPV70/6-84        AC Q6LCV5.1
#=GS Q9WNM6_9PAPI/22-113      AC Q9WNM6.1
#=GS H9LB00_RHPV1/6-93        AC H9LB00.1
#=GS Q82001_HPV72/6-106       AC Q82001.1
#=GS C3PUA0_RHPV1/6-90        AC C3PUA0.1
#=GS A0A059U437_HPV72/6-108   AC A0A059U437.1
#=GS Q9IR55_HPV82/1-88        AC Q9IR55.1
#=GS Q2VJB6_9PAPI/22-120      AC Q2VJB6.1
#=GS B2WUZ0_HPV53/45-150      AC B2WUZ0.1
#=GS C3PU76_RHPV1/6-92        AC C3PU76.1
#=GS Q676U8_HPV62/6-104       AC Q676U8.1
#=GS D3VWC0_9PAPI/5-105       AC D3VWC0.1
#=GS A4U7F6_HPV67/4-97        AC A4U7F6.1
#=GS Q8JN97_9PAPI/7-102       AC Q8JN97.1
#=GS F8QPQ4_9PAPI/5-108       AC F8QPQ4.1
#=GS Q8B5W6_9PAPI/40-141      AC Q8B5W6.1
#=GS F8S5A0_HPV58/4-88        AC F8S5A0.1
#=GS Q9DIH3_9PAPI/81-174      AC Q9DIH3.1
#=GS Q705H6_HPV43/21-114      AC Q705H6.1
#=GS A0A0P0E6A0_HPV54/46-134  AC A0A0P0E6A0.1
#=GS F8S3X0_HPV33/3-83        AC F8S3X0.1
#=GS VE4_HPV6A/3-91           AC Q84295.2
#=GS A0A159DWL1_HPV40/17-109  AC A0A159DWL1.1
#=GS VE4_HPV11/3-90           AC P04016.2
#=GS VE4_HPV31/2-99           AC P17384.2
#=GS Q76QV7_HPV59/26-115      AC Q76QV7.1
#=GS Q705C8_HPV94/5-100       AC Q705C8.1
#=GS VE4_HPV29/3-110          AC P51897.2
#=GS A3F915_9PAPI/22-132      AC A3F915.1
#=GS VE4_PCPV1/11-108         AC Q02266.1
#=GS VE4_HPV18/3-88           AC P06791.2
#=GS VE4_HPV16/2-92           AC P06922.2
#=GS T2A5W2_HPV39/3-91        AC T2A5W2.1
#=GS D0QMD3_RHPV1/6-91        AC D0QMD3.1
#=GS Q91AX2_9PAPI/13-105      AC Q91AX2.1
#=GS A0A385AHE3_9PAPI/7-113   AC A0A385AHE3.1
#=GS Q8JTB9_9PAPI/22-117      AC Q8JTB9.1
#=GS VE4_MMPV1/6-91           AC P24832.1
#=GS A0A161HD54_9PAPI/4-95    AC A0A161HD54.1
#=GS Q2VJC3_9PAPI/33-131      AC Q2VJC3.1
A0A386JT18_9PAPI/4-93               ...lhLCLAR--.....NKYPLLNLLHQpP......HT........PDAPIQCQV.PSAPRKt..rGTAR.................RRLA.SDLS.......SC----SSSP-----..T.......AQFPWTVETTD..SSLTVTTTTREGTSVVVILRL.
VE4_HPV28/3-97                      ..dts---AH--.....EKYPLLDLCAP.-......VT........PPRRRPKPR.-WARPK....--DR.................SKND.SDSRhs..tgsSSSDSTPKPPPRKPL.nE.......QVNHWTLQGPA..-TVTLHVHTPSGTQVTLTVHL.
Q6LCS2_HPV44/46-144                 .....LYLVLC-.....KTYPLLGLLHT.Ppp..ppPP........PLHRPHPHC.PLAPPR...tAWTR.................RHVN.DPED.......--PPQTPTTPETPSV.sE.......TATPWTVQTTT..SSLTVTTVTKDGTTIIVQLRL.
Q9JH47_HPV69/6-101                  .....LYLVPPG.....TKYPLLKLLNH.Y.....qTT........PPRPPKPPVcPGAPKK....-PRR.................QRQQ.SDDD.......LVDPTPLSPPPVLQG..-.......PEVPWSIQTTC..YTVTVEATTREGARVVTRLCL.
Q6LCV5_HPV70/6-84                   .....LCTVPVT.....TQYPLLSLLQN.Y......NT........PPRPIPPQQ.PHAPKK....-LSR.................RRLA.SVES.......----PDPQK------..Q.......TECSWTLL---..---QVKAATNDGTSVVVTLHL.
Q9WNM6_9PAPI/22-113                 .....LYLAPRTp...cGKYPLLQLVPG.Y......HT........PQTPPPAPR.CWAPPRa..pPKCR.................RRLS.SDSD.......-SSGTDSSSPTQPRQ..S.......TKSTWTVVPTD..TAVTVSAQTPQGTQ-------.
H9LB00_RHPV1/6-93                   .....LCLALPS....aRDYPLLKLLTD.C......SR........PPSPPPPTP.--APRK....--TRgq.............apPRRP.NEGD.......--EETPEGT------..-.......PCGPWTLTAEH..CSLNLRVTTPQGTQVTVTVRL.
Q82001_HPV72/6-106                  .....LYLAPRTp...cEKYPLLKLLGD.C......QT........PPNPPPPPR.AWAPPRh..pPQCR.................RRLV.SDSD.......STETDCSSSPTLRKE.tS.......AGNGVTVLTSG..STVTVTAHNKQGTSVTVTVHL.
C3PUA0_RHPV1/6-90                   .....LCLALPV....aTRYPLLKLLQD.C......-T........PPKSQRR--.RWGTGD....-QQQ.................HHQP.NEQE.......---LQTPQTP-----..L.......QCGPWTITATH..CSLEVSAQTPEGVVITVKLRL.
A0A059U437_HPV72/6-108              .....LYLAPRTs...cEKYPLLKLLGE.C......QT........PHNPPPPPG.VWAPPRq..pPKCR.................RRLV.SDSEf....teTDSSSNPSSPTPQKT..T.......LPENVTVLTSG..TTVTVTAQNTKGTTITVTVHL.
Q9IR55_HPV82/1-88                   .....MYLVPTA.....PRHPLLQLLNS.Y......RT........PPRPIPIPP.PRAPQK....-PRH.................HNNE.NDSD.......LLSPTPPQSP-----..-.......-RCPWTPATTK..YTVELQAQTPEGTSVQLKLRL.
Q2VJB6_9PAPI/22-120                 .....LYLAPRTp...cQKYPLLQLVTG.Y......HT........PTNPPPAPR.CWAPPRa..pPKCR.................RRLV.SDSD.......-STETEQSSPTPPKN..N.......IKSGWTLVPTD..STVTLSAQNAQGTTVTVTIHL.
B2WUZ0_HPV53/45-150                 .....LCPVPLD.....PTYPLLKLLTN.-......TT........PIRPPPPPR.PWAPTKp.hhPCGR.................ENVS.EPQSptvptppHSPLPQPESPTHSVSqgT.......HTTQTTTPENT..SLVELRVTTPK-STVVIRLHL.
C3PU76_RHPV1/6-92                   .....LCLALPS....aREYPLLKLLTD.C......SR........PQSPPTPTP.--PPRKt..rGSAH.................NRQP.NEAD.......------AQTP---EA..T.......RCGPWTLTAEH..CCLELHVKTPQGT-VTVTVRL.
Q676U8_HPV62/6-104                  .....LYLAPRTl...cERYPLLKLLDC.Y......-T........PPNPPPVPS.TWAPPRppkpPRCR.................RRLV.SDSE.......STDTERSGSPPLQKR..-.......TAGSWTITSTG..PTVTLTAQ-KDDTCVTVALHL.
D3VWC0_9PAPI/5-105                  .....LYPALRKa...cQKYPLLQLVYP.Cp....aTT........PPRPPPPPR.ACAPPRl..pPRCR.................RRLL.SDSD.......-SEETEDSSPTPHKT..D.......ECGLWTTTNQG..QTITVTTQSGLGSRVTVTVHL.
A4U7F6_HPV67/4-97                   ...lhLCLV---.....TKYPLLRLLPG.Y......HT........PQKRIPLPP.PRAPKK....---N.................RRLP.NDDD.......LTSQTSATTPSTPQSycA.......DNGPWTVHRWG..SSLDLSAQTKDGVCVHLTLHL.
Q8JN97_9PAPI/7-102                  .....LCLAPRTp..tkNRYPLLDLLTPhT......PT........NPTPPTPPR.CWAPRR....HTCR.................RRISvSDSD.......----TDISIPTPQK-..T.......GSSGWHVTTQG..TSVTLTAQSSTGTSVSVTVHL.
F8QPQ4_9PAPI/5-108                  .....LYLAPRT....pNKYPLLDLLRPdYtaenpfCT........PQRPPPEHN.GWAPPR...rRLGR.................QRNA.SGSE.......-SDLSSLQTLRSGCG..R.......NSGEWTVVSGP..SSVTLTAATSTGTAVTVTLHL.
Q8B5W6_9PAPI/40-141                 .....LYLVLC-.....KTYPLLGLLHT.P.....pPP........PLHRPPQQC.PLPPPR...iTWTR.................RPVK.DPEDvp...ptPTPPTTPTTPEAPCV.sQ.......TETPWTVQTTT..SSLTITTITKDGTTVTVELRL.
F8S5A0_HPV58/4-88                   ...lhLYLVI--.....-KYPLLKLLTQ.-......-R........PPRPPTTKV.------....----.................HRGQ.SDDD.......WIYQTPETTPSTPQS..I.......QTAPWTVDHEEedYTVQLTAHTKGGTCVVLKLHL.
Q9DIH3_9PAPI/81-174                 .....LYPVLREa...cQKYPLLQLLQS.Y......TT........PPPRPPLPP.PRKPPR....--CR.................RRLL.SDSD.......-LEETAPSSPILHRT..-.......SDHPWTVATHG..QTITLTTHSGHGTTVSVTVHL.
Q705H6_HPV43/21-114                 .....LYLVPS-.....VKYPLLRLLNL.-......-T........PDQRPPSQI.PRAPKKq..tARSK.................RRLE.SECD.......-STPTLPRSPTWPEL..L.......EEGQWTVQTRD..SCLSIRTTTLEGTTVEVTLRL.
A0A0P0E6A0_HPV54/46-134             .....LYLVPKR....hCQYPLLALLNT.-......--........PDQPIPHHV.PTTPQK...qSRAR.................RRLE.NELE.......STAQTSNHTA-----..-.......PQTPWAVTTTG..TSVTITTRTKDGTQVVVTLHL.
F8S3X0_HPV33/3-83                   .vlrl-YLA---.....TKYPLLKLLTY.R......--........-QTTITD--.------....--HH.................KQRP.NDDD.......LQTPQTPPSPLQSCS..V.......QTPPWTIEQ--..HVLQLTAQTSSGLCVVLTLHL.
VE4_HPV6A/3-91                      ..dds---ALH-.....KKYPFLNLLHT.-......--........PPHRPPPLC.PQAPRK....TQCK.................RRLE.NEHE.......-ESNSHLA---TPCV.wP.......TLDPWTVETTT..SSLTITTSTKEGTTVTVQLRL.
A0A159DWL1_HPV40/17-109             ..vll---VLSR....nKDYPLLRLLTP.D......--........-PRPLPPTP.QRPPKR...sAPPR.................HRPE.SDEE.......--TDTCPS-PLLWAN.hS.......EESTWTLQTEH..ARLTLKATTGTGTVVEVLLHL.
VE4_HPV11/3-90                      ..dds---ALY-.....EKYPLLNLLHT.-......-P........PHRPPPLQC.PPAPRK....TACR.................RRLG.SEHV.......---DRPLTTP---CV.wP.......TSDPWTVQSTT..SSLTITTSTKEGTTVTVQLRL.
VE4_HPV31/2-99                      .adpa----AV-.....TKYPLLGLLQS.Yq...qpTT........PPHRIPKPA.PWAPVK...vCGGR.................RRLL.SDQE.......--QSQSTETPTTPTS.cC.......EATPWTVSTVG..LSVQLHAQTKQGLSVVLQLHL.
Q76QV7_HPV59/26-115                 .....LCAVPVT.....SKYPLLDLLSN.Y......HT........PPQRPPKPR.TWAPKR....GTVR.................RRLE.SDQD.......SVDTHSTLSL-----..-.......PACQWTTVTTQ..SSVCIQATTRDGTSLAVTLRL.
Q705C8_HPV94/5-100                  .....LYLAH--.....EKYPLLDLCAP.-......AT........PPQRPPKPR.-WARPR....NRNKsd.............sdSRRS.TDSS.......SGSDKGPKIPPRKPV.nE.......RVDHWTVTAPG..CV-TLDVHSPSGLQVTLTVHL.
VE4_HPV29/3-110                     ..dns---AH--.....KKYPLLDLYTP.P......TT........PPARPPKPR.-WGLRR....--DRngndaglkqsglghsssSSSS.TSSS.......SSNRPRPTPPPRKPV.hE.......RVDQWTVTGPG..TV-TLQVKTPTGTQVILTVHL.
A3F915_9PAPI/22-132                 ....l-CLAPRPaprttNHYPLLELLYP.Qsq..pqSQpqqnqqeqEEQLRPPK-.RCAPPR....-RQR.................VRRP.SASG.......SSSDSSIPGPTLRER..S.......ERGKWSVTTSG..ASVTLTAQTPGGATVTLTLCL.
VE4_PCPV1/11-108                    .....LYLVLC-.....KKYPLLGLLHT.P......QP........PLHRPPAQC.HPSPQK...iVCKR.................RPIN.DFED......pPTVLENSKTPLTLCV.pR.......TVEPWTVKTTS..TITITTTTTSNGTTVTVVVHL.
VE4_HPV18/3-88                      ...dp--EVPVT.....TRYPLLSLLNS.Y......ST........PPHRIPAPC.PWAPQR....PTAR.................RRLL.HDLD.......TVDSRRSSIV-----..D.......LSTHFSVQ---..--LHLQATTKDGNSVVVTLRL.
VE4_HPV16/2-92                      adpaa------A.....TKYPLLKLLGS.Tw....pTT........PPRPIPKPS.PWAPKK....---H.................RRLS.SDQD.......--QSQTPETPATPLS.cC.......TETQWTVL--Q..SSLHLTAHTKDGLTVIVTLH-p
T2A5W2_HPV39/3-91                   .....LCAVPVT.....DRYPLLNLLPN.Y......QT........PPRPIPPQQ.PHAPKK....-QSR.................RRLE.SDLD.......SVQSQSPLSP-----..-.......TECPWTILTTH..STVTVQATTPDGTSVVVTLRL.
D0QMD3_RHPV1/6-91                   .....LCLALPT....aTNYPLLKLLAD.C......N-........PSTHHPPPP.TPAPRK....-TCG.................HRLQ.SE--.......CVGQTQVEI------..-.......QCGPWTVKAGQ..FFVDLRTTTPQGVPVTVTIRL.
Q91AX2_9PAPI/13-105                 .....LYPVLRE....eCRYPLLKLLHS.R......CT........PPPRPPPPP.PRKPPR....--CR.................RRLL.SDSG.......-SEATAYSSPTLQET..-.......SEHSWTVASQG..HKITLTSHSGRGTTVTVTVHL.
A0A385AHE3_9PAPI/7-113              .....LYLAP--.....SKYPLLQLLSS.Qt....pTT........PTRPIPAAApPGAPRK....DKSR.................RHLYlNDPD.......PDSDCSCSSPTLRRRrlErwdgwhpQQAPWTVSAKG..NTVTLTATGVNGPTVSVTLHL.
Q8JTB9_9PAPI/22-117                 .....LYLVPRTl...cEKYPLLQLVTG.Y......TT........PPHPLPAPT.VWAPPRq..pPRCR.................RRLI.SDSD.......-STETECSSP---PQ..Q.......HKSTWTVATGG..STVTLTAQNDSGSRIVVTLHL.
VE4_MMPV1/6-91                      .....LCLALPT....aTNYPLLKLLAD.C......NT........STHHPPPPT.-PAPRK....-TCG.................HRLQ.SE--.......CVGQTQVEI------..-.......QCGPWTVKAGQ..SFVDLHTTTLQGVPVTVTIRL.
A0A161HD54_9PAPI/4-95               ...lhLCLAA--.....TKYPLLKLLGS.Tw....pTT........PPRPIPKPS.PWAPKK....---H.................RRLS.SDQD.......--QSQTPETPATPTS.cC.......TETPWTVL--Q..SSLQLTAHTKDGLTVIVTLH-p
Q2VJC3_9PAPI/33-131                 .....LCLAPRTp..skNPYPLLDLLTHrT......PT........NPTPPPPPP.CWAPRR....PSCR.................RRLSvSDSD.......--TDLSTQSNRTQQG..T.......GVSGWHVTTQG..TSVTLTARTSTGTSVSVTVHL.
#=GC seq_cons                       .....LhLs........p+YPLLpLLss.h......pT........Psps.Psss.shAP.+.....tsR.................RRlt.SDp-........sspssspoP...t...t.......ppssWTVpsss..soloLospTtpGTsVsVTL+L.
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