#=GF ID   DUF6317
#=GF AC   PF19840.4
#=GF DE   Family of unknown function (DUF6317)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   27.40 27.40;
#=GF TC   27.60 27.40;
#=GF NC   27.10 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   29324854
#=GF RT   Characterization of the biosynthetic gene cluster for cryptic
#=GF RT   phthoxazolin A in Streptomyces avermitilis.
#=GF RA   Suroto DA, Kitani S, Arai M, Ikeda H, Nihira T;
#=GF RL   PLoS One. 2018;13:e0190973.
#=GF DR   INTERPRO; IPR045558;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0001740) is described by MIBiG as an example
#=GF CC   of the following biosynthetic classes, NRP (non-ribosomal
#=GF CC   peptide) and polyketide, in particular the phthoxazolin
#=GF CC   biosynthetic gene cluster from Streptomyces avermitilis [1]. 
#=GF SQ   49
#=GS A0A370I4T3_9NOCA/1-100  AC A0A370I4T3.1
#=GS A0A5A7S940_9NOCA/1-99   AC A0A5A7S940.1
#=GS A0A7Y7EAJ2_STRMO/1-100  AC A0A7Y7EAJ2.1
#=GS A0A6I1ZFD6_9ACTN/1-99   AC A0A6I1ZFD6.1
#=GS A0A197SHR4_9ACTN/1-96   AC A0A197SHR4.1
#=GS A0A1J4NYV9_9ACTN/1-100  AC A0A1J4NYV9.1
#=GS A0A931GQG3_9ACTN/1-100  AC A0A931GQG3.1
#=GS A0A5N5WD66_STRMB/1-100  AC A0A5N5WD66.1
#=GS A0A1B1AVB2_9ACTN/1-96   AC A0A1B1AVB2.1
#=GS A0A0M9YPC6_9ACTN/1-100  AC A0A0M9YPC6.1
#=GS A0A923QAF9_9ACTN/1-99   AC A0A923QAF9.1
#=GS A0A4R7MND9_9ACTN/1-98   AC A0A4R7MND9.1
#=GS A0A1J4PVD7_9ACTN/1-100  AC A0A1J4PVD7.1
#=GS A0A1K2FS40_9ACTN/1-100  AC A0A1K2FS40.1
#=GS D6ZCV5_SEGRD/1-100      AC D6ZCV5.1
#=GS A0A2G1XG12_STRCJ/1-100  AC A0A2G1XG12.1
#=GS A0A1S2QLU5_9ACTN/1-83   AC A0A1S2QLU5.1
#=GS A0A543CFX4_9ACTN/1-92   AC A0A543CFX4.1
#=GS A0A0K9XI58_9ACTN/1-100  AC A0A0K9XI58.1
#=GS A0A918G1Z1_9PSEU/1-95   AC A0A918G1Z1.1
#=GS A0A5A7SIV1_9NOCA/1-98   AC A0A5A7SIV1.1
#=GS A0A2A2Z1V8_9ACTN/1-100  AC A0A2A2Z1V8.1
#=GS A0A0L0KP23_9ACTN/1-98   AC A0A0L0KP23.1
#=GS A0A561UMN0_9ACTN/1-97   AC A0A561UMN0.1
#=GS A0A420XN06_9ACTN/1-98   AC A0A420XN06.1
#=GS A0A1M5WPA2_9ACTN/1-100  AC A0A1M5WPA2.1
#=GS A0A1H5DLL0_9ACTN/1-100  AC A0A1H5DLL0.1
#=GS F8JXD9_STREN/1-100      AC F8JXD9.1
#=GS A0A101TCB1_9ACTN/1-86   AC A0A101TCB1.1
#=GS A0A561UEV0_9ACTN/1-98   AC A0A561UEV0.1
#=GS A0A0Q9AE43_9ACTN/1-100  AC A0A0Q9AE43.1
#=GS A0A919HDM6_9ACTN/1-99   AC A0A919HDM6.1
#=GS A0A1H0UHH2_9ACTN/1-101  AC A0A1H0UHH2.1
#=GS A0A367H8A0_9ACTN/1-100  AC A0A367H8A0.1
#=GS A0A0C5FUA2_9ACTN/1-100  AC A0A0C5FUA2.1
#=GS A0A0L8LFK6_9ACTN/1-100  AC A0A0L8LFK6.1
#=GS A0A176L671_9ACTN/1-100  AC A0A176L671.1
#=GS A0A1H9UFI4_9ACTN/1-100  AC A0A1H9UFI4.1
#=GS A0A918Y4Q6_9ACTN/1-100  AC A0A918Y4Q6.1
#=GS S5UZE7_STRC3/1-99       AC S5UZE7.1
#=GS A0A8J3BZR8_9ACTN/1-102  AC A0A8J3BZR8.1
#=GS A0A931AZ76_9ACTN/1-85   AC A0A931AZ76.1
#=GS A0A540W8S9_9ACTN/1-101  AC A0A540W8S9.1
#=GS A0A916THL4_9ACTN/1-101  AC A0A916THL4.1
#=GS A0A940ML48_9ACTN/1-97   AC A0A940ML48.1
#=GS A0A117PY76_9ACTN/1-86   AC A0A117PY76.1
#=GS A0A1S2PRX2_9ACTN/1-99   AC A0A1S2PRX2.1
#=GS A0A919E055_9ACTN/1-100  AC A0A919E055.1
#=GS A0A0N1GW49_9ACTN/1-100  AC A0A0N1GW49.1
A0A370I4T3_9NOCA/1-100             ......MSDWFQVVLDDLKTMAKTFDDEAKTYEG.LVPKF..SP.APVDSGDATLNEAMKGAADLLQILHHQMVRTIQTHAEKLSYARDSYER.HD.ID.NRKLYDDLTKN--ld.....
A0A5A7S940_9NOCA/1-99              .....m--AGFEVVLEDLQSMATTFNEQAGAYRA.VTPKL..TP.AEADSGDGALNAVMHAVLELIGVLHQQLATSITQHSEKLATAHDSYQR.RD.ID.NRFLFDDLMKD--vd.....
A0A7Y7EAJ2_STRMO/1-100             ......MSDKLRATVDHIDDTGRAFQREAVDLGR.TAHLA..SP.PTPGVGDVALSSALLRLSDAFGAAHRMMTGLIDGHGSKLRKAAADYQN.TD.ID.LHGMFDDLIDKY-k......
A0A6I1ZFD6_9ACTN/1-99              ......MTADFKVIYDDLATLAKTFHDQASDYRK.LKPDV..TP.PVVSGGDPGLDSAIKEVADLIESLHLLLADRLDEHGDKAAYARDSFHR.HD.VD.IHGVFEDLTPE--d......
A0A197SHR4_9ACTN/1-96              ......MSADVKVILADLNSMASAFREEAGIYRG.MHANV..KP.GAAGSGDPGCDAAIKSMADLIAGLHDKLSDRLDDNSDKVKYAHDSMQR.ND.ID.VHGLFEDLM----.......
A0A1J4NYV9_9ACTN/1-100             ......MMADFQAVMSDLTAMTKTFHDQARDYRG.LGPDV..TP.PVADSGDGGCDHAIKEIADLIVALHIGFADRLDDHGDKVAYARDSFQR.HD.VD.VHGVFEDLMTGE-g......
A0A931GQG3_9ACTN/1-100             ....mn---GFSAQIDSLVEAGRRFQKVAVDYKG.DMPAG..GF.ERPSTGDGKSDAMLETTLKMIDLLHGALADAVWQHGEKLQLVAERYQTaED.EN.ITTLYQA------vneaat.
A0A5N5WD66_STRMB/1-100             ......MADRLRATVEHIDDAGKGFHREALEFGK.FKHLA..SP.ATPRVDDAGLSEALSVLSEAFGLAHQLLTGLVDTHGTNLRGAASDYHN.ED.ID.RGKLLNDLMGR--lk.....
A0A1B1AVB2_9ACTN/1-96              .....m--SDFKVVYDDLSTMAKTFHDQAGDYRK.LRPDV..AP.PVVSGGDAGLDSAIKEVADLIIALHIGMADRLDDHGDKVAYARDSFHR.HD.VD.VHGVFEDLM----g......
A0A0M9YPC6_9ACTN/1-100             ......MAADFKAILSDLSSMSKTFHDEAVNYRK.LHSDV..AP.PVAGGGDAGLDHAIKEVADLIVALHIGFADRLDDHGDKVTYAHDSFQR.HD.ID.VHGLFEDLMVGD-g......
A0A923QAF9_9ACTN/1-99              ......MAASFEVVLADLQSMAGTFHTEADGYRA.LVPGI..TP.TAVDAGDSGLNSVMASVFTSLASLHELMAESIAQHGDQLTKAHDAYAA.QE.ID.NRFLYDGLG----ret....
A0A4R7MND9_9ACTN/1-98              ......MGSGYQVVLGDLQRMADTYHSEADAYRG.LKPQV..AP.AVADGGDTGLNDSIQLIMAAIDSIHTKLADRIEEHGDKLAYVHGSYQR.RD.VD.VHGAFEDLMA---e......
A0A1J4PVD7_9ACTN/1-100             ......MTADFKVVYDDLTGLAKAFHEQAGDYRK.LAPDV..SP.AIVGGGDPALDSAIKEVADLIIGLHTGLADRMDDHGDKAAYARDSFHR.HD.VD.IHGVFEDLTEG--ld.....
A0A1K2FS40_9ACTN/1-100             ......MTADFKVIYDDLSTLAKTFHDQAGDYRK.LAPDV..SP.PIVSGGDPALDAAIKEVANLVIALHIGLADHLDDRGDKAAYARDSFHR.HD.VD.IHGVFEDLTEG--ld.....
D6ZCV5_SEGRD/1-100                 ......MGDWSKVVLDDLAAMSQQFEQGHADFEA.AVEAV..KA.EPVDTGDGTLNDYLQYVTGRIEELTIKSAELIKEHAGKVKYAHDSYER.HD.ID.NEELFEDMDFEYK.......
A0A2G1XG12_STRCJ/1-100             ......MSDELRTTVEHIDDAGKGFHREAIHLGE.FKHLA..SP.ATPGVGDLALSSALVQLSDAFGIAHELLTGLVDRHGTSLRGAAADYQD.QD.VD.IETLFRDMMGKAK.......
A0A1S2QLU5_9ACTN/1-83              ......--------------MASTFHTEAKSYAK.LHTSV..SP.AVAKSGDDGLDHTIGSMMDAISGLHARLAGRIEEHGDLLDAAVKHLTH.RD.ID.VHGLFEDLM----g......
A0A543CFX4_9ACTN/1-92              ...msg----YDVIFDDLVKASAEFSKQGEAYAN.LMPH-..KP.ACPAGGDDAIDKMLNVTLQALYEMHTVLAQSISAHAYKLDYAHRHYSK.VE.RD.V------------fdhive.
A0A0K9XI58_9ACTN/1-100             ......MADKLRATVEHIDEAGKGFHREALHLGE.FKHLA..SP.STPRVGDAGLSEALSVLSEAFGLAHELLTGLVDTHGTNLRGAASDYHH.ED.LD.RRKMFDDLMGRAK.......
A0A918G1Z1_9PSEU/1-95              ..mggf-----TARVDSLREAASAAGSLGEELRArAEGLL..TA.DTGDPGHAGLAQEMRAFAERLRALADGFTDEVDSIGERLTASAAAYTD.TD.GE.AAGVF--------taw....
A0A5A7SIV1_9NOCA/1-98              .....m--ADFKVVLDDLKLMANDFDQNSEVYRG.LARQV..SP.PAADTGNGDVNAVLRSITEAFAVLHEKLATSIQNHADKLYDAHDSYQD.RE.ID.NRFLFDEIVE---dl.....
A0A2A2Z1V8_9ACTN/1-100             ......MSVDFKAVLSDLTSMSKTFHDEAVNYRK.LHADV..AP.PLVSGGDAGLDHAIKEVADLIVALHIGFADRLDDHGDKVTYARDSFQR.HD.ID.VHGLFEDLMADD-g......
A0A0L0KP23_9ACTN/1-98              .....m---DFNVVLGDLTSMASTLHTEATNYRA.LHGQV..TP.AVVSGGDPALDHAVSEAAHLISGLHTLFADRMDDHGDKVAYARDSFHR.HD.ID.VHGLFEDLMKGE-g......
A0A561UMN0_9ACTN/1-97              ......MSAGYDVVLEDLRSMAATFHQEAQAYVK.LKTDV..AP.PIAASGDSGLDSSITSMMEAIAGLHAKLAGRIEGHGDKLQYAHDSYQR.HD.VD.EHGVYEDLM----n......
A0A420XN06_9ACTN/1-98              ......MADSFELVLADLQSMSGRFAKEADVYDA.SHSDV..TP.AQAATGDGSLDGTLRAVMEALDILHTSMGETIREHGEKLKAARESYER.HD.VD.VHGLFDDLME---g......
A0A1M5WPA2_9ACTN/1-100             ......MPPDFKAVLGDLTSMSKTFHDEAVNYRK.LHADV..AP.PLVSGGDAGLDHALKEVADLIVALHIGFADRLDDHGDKVTYASDSFQR.HD.ID.VHGLFEDLMAGD-g......
A0A1H5DLL0_9ACTN/1-100             ......MSADFKAVLSDLTSMATTFHDQATDYRK.LQPQV..SP.PVVSGGDAGLDDAIKEVAHLILGLHIGFADRLDDHGDKVAYARDSFHR.HD.VD.VHGVFEDLMVGD-g......
F8JXD9_STREN/1-100                 ......MTADLKAVLGDLKATGDAFHRAADDYRG.LTPHV..SP.ALADGGDPGLNDAIREVSDLIRALHTAFADRLRSHGDQVHHAHDAYQR.QD.DD.THQLFDDLMHGD-g......
A0A101TCB1_9ACTN/1-86              ......--------------MAKTFHEQAGDYRK.LHADV..AP.PVVSGGDPGLDAAIKEVADLIVALHLGMADRMDDHGDKVAYARDSFHR.HD.VD.VHGVFEDLMAGE-g......
A0A561UEV0_9ACTN/1-98              ....ms---QYTVVLDDLKGAADTFHQESKTFAG.IMPDD..GP.AQVDGGDGAVNAMMQTVFEALGGLHLAVAGSISNHGDNLQKAHDNYQN.CE.VS.VRELYDDIS----eps....
A0A0Q9AE43_9ACTN/1-100             ......MPPDFKAVLGDLTAMSTTFHDEAVNYRK.LHADV..AP.PLAGGGDAGLDHALKEVADLIVALHIGFADRLDDHGDKVTYARDSFRR.HD.ID.VHGLFEDLMTED-g......
A0A919HDM6_9ACTN/1-99              .....m--ADFKAVLGDLTSMSATFHREAGNYRG.LHAQV..AP.PVVSGGDGGLDHAIKEVADLIVALHTGFADRLDDHGDRVAYATASFRR.HD.ID.VHGLFEDLMVGE-g......
A0A1H0UHH2_9ACTN/1-101             ......MGDHFKVEVNDLDRLIKELHSSQDNMRK.ALNAL..KDvGPKSTGSEALDNACDEFHDSWDNAIKKIADGTEAIEERLKQTKNNYEQ.TE.QA.IRDAFEK------aektsq.
A0A367H8A0_9ACTN/1-100             ......MSVDVRLVLSDLSTMAATFHTEAENYRK.MHQNV..KP.AVAGSGDAGCDAAIKAMADLIAGLHDKLSDRLDDRSDKVKYAHDSMQR.HD.ID.VHGLFDDLMKD--rt.....
A0A0C5FUA2_9ACTN/1-100             ......MGDHFKVEVNDLDRLIKELHNSQDNMRK.AINAL..KDvGPKSTGSEALDNACDEFHDSWDNAIKKIADGTQAIEERLKQTKNNYEQ.TE.QA.IRDAF--------tqaenrk
A0A0L8LFK6_9ACTN/1-100             ......MPADFKAILSDLTSMSRTFHDEAVNYRK.LHTDV..AP.PVADGGDAGLDHALKEVAELIVGLHTGFADRLDDHGDNVAHARDSFQR.HD.ID.VHGLFEDLTVGD-g......
A0A176L671_9ACTN/1-100             ......MSADFKVIYDDLSTLAKTFHDEAGDFRK.LHGDV..AP.PVVSGGDPGLDSAIKEVSHLIIGLHVLLADRMDAHGDKVAYARDSFHR.HD.VD.VHGVFEDLMPDE-d......
A0A1H9UFI4_9ACTN/1-100             ......MPPDFKAVLGDLTAMSKTFHDEAVNYRK.LHADV..AP.PLVSGGDTGLDHALKEVADLIVALHTGFADRLDDHGDKVTYARDSFQR.HD.ID.VHGLFDDLMEGD-g......
A0A918Y4Q6_9ACTN/1-100             ......MPADFKAVMGDLTSLARTLHEQARAYRE.LGPSL..SP.PGASGGDAGLDAALREVALLISALHCGFADRLDDHGDLVAKSRDAFQR.HD.ID.VHGLFDDLMPE--gg.....
S5UZE7_STRC3/1-99                  .....m--SDFKAVYDDLAAMARTFHEQAGDYRK.LRPDV..AP.PVAAGGDAALDSAIKEVADLIVALHAGMADRMDDHGDKVAYARDSFHR.HD.VD.VHGVFEDLMAGE-g......
A0A8J3BZR8_9ACTN/1-102             ......MGDDYHVAVSRGTALADTFARAQDPLLR.LAAPLrgAC.EAIRTGDAGLDAETAAVARRVDGLYRLMAQVFATLSANVSDAVADYRD.AD.EA.VAAAFRELMSDD-t......
A0A931AZ76_9ACTN/1-85              ......--------------MAKTYHTQADDYRS.LKMQV..TP.PLADGGDPGFNDALQTIMNAVDSLHTKVGDRIADHGDKLGYAHDSYQR.RD.VD.VHGVFEDLMPD--s......
A0A540W8S9_9ACTN/1-101             msgsgy-----GVLLGDLQALADDFGTEAKAVQQ.LHGDV..DL.KPVSTGDANLDATLGAVLMNLKGLIDGTAKQLGDHGSKMQSCHDNYKS.SD.SD.HARLLDSLMSA--an.....
A0A916THL4_9ACTN/1-101             .....m--SDLHVVLGDLDGLSSRFAQQADAYQA.LIPKM..SP.PAAGTGNGSVNATVAAVMDLFTLLHPQMVASIESHSKKLHNAREAYNR.TEeVNrNRFLYDDLVEG--fk.....
A0A940ML48_9ACTN/1-97              ..mgkp---DYQVVLGDLGAMATRFKKEAVAYHG.LHHEV..KP.SVAASGDAGLDSMIKAMADLIAGLHDKLGDRIADHGDALQYAHDSYHR.HD.VD.VHGVFEDLM----.......
A0A117PY76_9ACTN/1-86              ......--------------MAKTFHDEAGDYRK.LHPDV..AP.PVVSGGDAGLDSAVKEVADLIISLHIGMADRMDDHGDKVAYARDSFHR.HD.VD.VHGVFEDLMAGE-s......
A0A1S2PRX2_9ACTN/1-99              ......MTADFKVIYDDLATLAKTFHDESGNYRK.LAPDV..TP.AVVSGGDPGLDDTIKAVADLITSMHLALADRLDEHGDKAGYARDSFHR.HD.VD.VHGVFEDLTPE--d......
A0A919E055_9ACTN/1-100             ......MPADFKAVMSDLTSMAETFHDQARAYRE.LRPSV..TP.PVADGGDGGLDSAVKEVAHLISALHLGFADRLDDHGDLVAKSRDSFRR.HD.ID.VHGLFEDLMVGD-g......
A0A0N1GW49_9ACTN/1-100             ......MTVDFKAVLSDLASMSRTFHDEAVNYRK.LHADV..SP.PLAGGGDAGLDHAVKEVADLIVALHIGFADRLDDHGDKVTYARDSFQR.HD.ID.VHGLFEDLMAGD-g......
#=GC seq_cons                      ......Mssca+sllsDLsshucTFHcpAssYRp.LpssV..uP.sssuuGDuGLDsAl+plu-hIsuLHtthAD+l--HGDKlsaA+DSapR.+D.lD.lHGlF-DLM.t..s......
//