#=GF ID   DUF6548
#=GF AC   PF20185.3
#=GF DE   Family of unknown function (DUF6548)
#=GF AU   Paysan-Lafosse T;0000-0001-5663-0894
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   MGnify-UniProt clustering
#=GF GA   27.30 27.30;
#=GF TC   27.30 28.20;
#=GF NC   26.80 26.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR046678;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is functionally uncharacterised. This
#=GF CC   family of proteins is found in bacteria. Proteins in this family
#=GF CC   are around 180 amino acids in length. They contain highly
#=GF CC   conserved motifs, YKxLD and I/LC at the N-terminal and LKxxRxxRN
#=GF CC   in the middle.
#=GF SQ   33
#=GS A0A1M6JHB8_PSEXY/11-124  AC A0A1M6JHB8.1
#=GS V1CGM3_9FIRM/6-190       AC V1CGM3.1
#=GS R6C2L9_9CLOT/7-167       AC R6C2L9.1
#=GS A0A1H6QVH4_9FIRM/6-149   AC A0A1H6QVH4.1
#=GS A0A1H5V1Q3_9FIRM/6-108   AC A0A1H5V1Q3.1
#=GS R5TSD0_9FIRM/1-161       AC R5TSD0.1
#=GS R5XL73_9FIRM/1-161       AC R5XL73.1
#=GS R6NMA6_9FIRM/6-177       AC R6NMA6.1
#=GS A0A1Y4TKC9_9FIRM/1-158   AC A0A1Y4TKC9.1
#=GS A0A1H5U213_9FIRM/6-165   AC A0A1H5U213.1
#=GS R5ED23_9FIRM/6-163       AC R5ED23.1
#=GS A0A1G4W8A2_9FIRM/2-161   AC A0A1G4W8A2.1
#=GS A0A810Q2P9_9FIRM/1-165   AC A0A810Q2P9.1
#=GS R5LBG8_9FIRM/6-158       AC R5LBG8.1
#=GS A0A1I0CH28_9FIRM/1-137   AC A0A1I0CH28.1
#=GS G2T341_ROSHA/7-209       AC G2T341.1
#=GS A0A8T4JPM3_9FIRM/2-160   AC A0A8T4JPM3.1
#=GS H1PKP0_9FIRM/1-161       AC H1PKP0.1
#=GS A0A1Y3TIF6_9FIRM/6-164   AC A0A1Y3TIF6.1
#=GS R5CWC5_9FIRM/6-159       AC R5CWC5.1
#=GS R6RRF0_9FIRM/6-165       AC R6RRF0.1
#=GS A0A1H7LFN3_9FIRM/9-128   AC A0A1H7LFN3.1
#=GS R6DZZ2_9FIRM/6-174       AC R6DZZ2.1
#=GS R6Q7Q8_9FIRM/1-159       AC R6Q7Q8.1
#=GS A0A4Z2H0T7_9TELE/10-89   AC A0A4Z2H0T7.1
#=GS A0A834N6M0_VESGE/10-85   AC A0A834N6M0.1
#=GS A0A1I0F9X2_9FIRM/6-184   AC A0A1I0F9X2.1
#=GS R5YY43_9FIRM/6-157       AC R5YY43.1
#=GS B1C312_9FIRM/6-147       AC B1C312.1
#=GS A0A143ZRW2_9FIRM/1-158   AC A0A143ZRW2.1
#=GS W7UWX5_RUMFL/6-171       AC W7UWX5.1
#=GS A0A1T4M2Y2_9FIRM/1-130   AC A0A1T4M2Y2.1
#=GS A0A4U7J7D2_9FIRM/1-155   AC A0A4U7J7D2.1
A0A1M6JHB8_PSEXY/11-124             ...................e-RFYDAYILFDDMLAQKFKL.....eEGGVAKYMAKMKECYTEAREHIPEWDDTFKRLQHLQARFNSLKDGKVAFEHFQGKDEDVVWMSVFKEKMDAEADVLSKYSKId................fS--KKK----------....................------------------------.----------------------kdegf.........................................
V1CGM3_9FIRM/6-190                  ....................MEFFDKYKDVDKFCGDMLSS......DSGISEYIDQMEKTPASERRYVPSWERDYRMLKHLRYVRNQIAHANNDV---ISTEEDFFELNEFYDRLLSGNHPFALIRINsk..............raERISKHSGVKNDGTSNtehtgysnydsrqhsydydnKIRSTDRNNYNHNSTNYGKNSGSP.LKILALSAFVIAVLLIAYYMS-q.............................................
R6C2L9_9CLOT/7-167                  ...................y-VFFEEYKKISNLCNDMLQV......QNGVTEYINELEKIAG---RREPEAQSVLRQLKRMRHLRNLLAHGEGTFEQELCSAQDVEWIRDFHQKLLTQTDPLALYNQK..................KRRNQSGQQAEQQGRQ....................KEFERLQPKEVKNAGQNERESETG.ESVVIVGVVLGVVIWLILWII-y.............................................
A0A1H6QVH4_9FIRM/6-149              ...................v-KFFDEYKFVDNICRDMFQS......NQGVTEYIKQMEVMDAEGSRIVVNWREKYKKLKHLRWLRNKIAHESGAPD---LTENDLIELQNFHNQLLKQVDPLAELWKK..................RRVYKRNVVKQE----....................-------------YYNPESDDSAI.SVFILICIVIIVIGLFWIFAS-f.............................................
A0A1H5V1Q3_9FIRM/6-108              ....................MEFFDEYKKLDVTLKNKYST......KTGVTSYIENMERFSD-GEGFVPSWREDYKALKHYRWLRNKLAHEAGED--VNLDKSDLAGLKKFFANVSKNKDPYTLYLAS..................----------------....................------------------------.----------------------kkgk..........................................
R5TSD0_9FIRM/1-161                  ....................MNFIDSYKKLEKLCNEMYGD......KHGVSLYIDEMINTPV-GSRYVKSWNEDLKQLKHYRWARNQIVHEPGCTETNMCNRDDIQWINNFYIRMMSTSDPLALYRKT..................IRSNRKTHSSSGGK--....................SASRQCDDSQQKGKHSRFSQESHR.CGVFVWGTIIAVIVIFLFFKV-i.............................................
R5XL73_9FIRM/1-161                  ....................MSFTESYKQLEKLCGEIMND......DRRVSAYIDEMINTPR-GSYLVKGWDSDLKQLKHYRWIRNQIAHTPDCTEQNMCKPGDAEWLDGFYFRIMNQTDPLTLY---..................AKATAPKPTEKAAPTP...................kTKAETYPCSQQATKSKKTSKKAIG.FVIFAAMIALAVAVIFIISKS-f.............................................
R6NMA6_9FIRM/6-177                  ....................NEFYEAYKKSASFCDDLYQKereknyKSGIKYYIEDMEHTPFSVARMIPNWNSDLKKLKYLLYLRNQLSHDINTSPGSLATSDDTLWIQSFYQRLLNQSDPLALK---..................HQLLSPNRNTNTPAKSvs...............tpnQSMQHRTMPYNPLYANEADREPQN.MHFHWTWIVIAFIVLFFIYL--ga............................................
A0A1Y4TKC9_9FIRM/1-158              ....................MSFMQSYKRLDVLCRDMNGI......--GISGYIADMEQLTN-GRLFVAGWEEDYRLLKHYRHIRNRIAHDVDATEDALCTAEDAAWIEEFYGHILNQTDPLAVYCKA.................sLQQKSVRRTAES----....................------------------------.----------------------fssgiscappslprpncklnanlplivtllaggaavfillillflq
A0A1H5U213_9FIRM/6-165              ...................d-EFMEAFKHLDKICKEMFNA......EKGVTSYIDEMERISS-GPRYVPNWNYVLRRLKDLRHIRNTHSHEIGTSYGDICSPEDVQWLESFYSEIMNTTDPLAQY---..................RKATAPKPKPKMPTST....................QYNPNDFHTFTPQYEQEEEETISG.LAIFIICLVVVAVVVGVFFAVF..............................................
R5ED23_9FIRM/6-163                  ....................NEFFEEYKHLERLCSDMYSC......RDGIRQYLEDMECQFSEGKKTIPHWAQDYRKLRGLRRTRNTLAHNVSEYQ--VCTEQDVENVIDFVDRIMQQQDPLAMLNLY..................NS---KDEESETMDES....................-EVSVPGSFYYDAPRNEKKGKQLI.LGVVLLVITCVMVILVSILIS-h.............................................
A0A1G4W8A2_9FIRM/2-161              ...................k-EFIDAFKHLEKLCNDIYGE......QHGVTLYIKEMEDTPNYMAQKVFGWDHDLKALKRVRLIRNKWAHPDDEMD---YTFEDIEFLKNFYSRVMNQQDPLAMLRQK.................nKEVRSKNKAISEPVIP....................--YKPQDSARAYNIEEEGAELNRL.KTIAIFFIVLSAIIIVGAL---gwl...........................................
A0A810Q2P9_9FIRM/1-165              ....................MGFIDSYKRLEKLCGDVMGC......DRPVTAYIDEMKATPH-GAYYVAGWGSDLEMLKRYRWIRNQIAHEPGCTEANMCGAGDAAWIDQFYGRIMDQTDPLALYEKE..................MKRQRAEQAQRSRPES...................vRPAEKKPPQEPRKRESIEKAPRRKwGTVVLAFLLFAVIFLAS-----fagli.........................................
R5LBG8_9FIRM/6-158                  ....................NKFFEKYKELDSLCKDVLNS......NQGVTQYICEMEKTSGRGRYYVHSWDYDYKMLKHVRWVRNNIAHNNGGSE---CSENDIKYVKDFYQRIMQQKDPFSIIYQR..................-----QNEIKKRTVKQ....................---SEIKPNPYINNRKTTNKNRGY.TRLAVGIFIVIIVVLLMIMS--rl............................................
A0A1I0CH28_9FIRM/1-137              ....................----------------MYAA......SQGVTEYINRMEVFSNEGRYLIDKWNTDYYTLKHLRWLRNTIVHNLEETD---CSLEDLQSLKEFYQQILNRKDSLALLYMM..................KQKHL---TKEKLSIH....................-----QDKQILENVRYKKQNRRNL.FNITIVLIIAVLVMIVLNF---kif...........................................
G2T341_ROSHA/7-209                  ...................i-IFFDEYKKLDKLCSEMYGI.....nSGGVTCYLNDMMAVPVMQRNRIPEWNQTYDRLRELRHIRNQMAHGEGSFEDYPCSEEDVLWLFEFRSKIMHISDPLAVYRSQteesmhatrikedfpravDQSQTEESMHATRAKEdfllavdqsqtegniadhqrMKMDNVEVIDQEENDSFEKKHSML.KKIAVFGLIVLIVAAAVLIF--gn............................................
A0A8T4JPM3_9FIRM/2-160              ...................a-DFISSYKHLEKLCGDILQD......DRRISAYIDEMTKIAS-GSSAVHGWNEDLKKLKHYRWVRNQIVHDPDYEEEDLCGPNDVLWLENFYSRIMNQTDPLALYYHL.................tKKVGEDNRKKQESVRT....................---NTYDTYNRQPMPRREPEHSSG.GMILVVC-VIIIVACVLF----lgk...........................................
H1PKP0_9FIRM/1-161                  ....................MGFMDSYKHLEKLCGDMFGD......ERRISAYIDEMYENTE-GWDLVDGWESDLKKLKHYRWVRNRIVHEPDAYEDELCDAEDIEWLDDFYYRIIDREDPLNRY---..................YEIVRSRKSIKHASEQ...................rMDSASYGKNSSSQCSDDKPGKILP.GFLCFLCFFFAVVILFMILG--ei............................................
A0A1Y3TIF6_9FIRM/6-164              ....................NEFFEEYKRLDRLCSDMYSS......KNGVSRYIEDMESRSCRGADSILSWNTDYKLLKHLRWIRNRIAHDTDDYQ--ISSESDLKNMRNFYERIFSGQDPIALLEKS..................NADGGCREEEVQALKD....................---QKNMQYSHNPNKQKSFANGCL.VRVAVIALVFIAVGVVAAIA--fl............................................
R5CWC5_9FIRM/6-159                  ....................NDFFEEYKRLDRLCADMYSC......RNGVSEYIAQMENRFYQGQFRVPSWSSDHKMLKHVRWVRNQIAHDSGAYQ--ISEPSDLEFVLNFYERIFSGQDPLTLLRKA..................TEAEAERRKRQARSAT....................--------STPPDNESTGKPLGIV.IGIGIVALVLTIIFAAILLRS-l.............................................
R6RRF0_9FIRM/6-165                  ...................v-DFFETYKKLDRLCAQMYGL.....sGGGVTAYIDDMKDNWA-AAYGTDNWNETFNTLRRLRHMRNEMAHDEGAFDVLNCTMEDINWLNSFYYALMNGYDPLSCIR--..................KKAAEHYRQVKPPVNN....................--TYYVRNTRYTEPLDYGQKHHDT.GKVAAMIIDIVIILLALVYYI-f.............................................
A0A1H7LFN3_9FIRM/9-128              ...................e-NFYDEYQYFDSVLAKRFKI.....eENGVVRYIKEMKNAVIDVRDVLPEWDPTIARLQKMKVRYDSLDNAESSFDDFQGKDEDVVWIKVFLTKLESHADPLSKYSKLe...............ftYKKR------------....................------------------------.----------------------kksffqklka....................................
R6DZZ2_9FIRM/6-174                  ...................n-LFFEEYKKLDKLCSDIYND......KYGISTYIKDMEDNDYIGQKAVKSWHRVYKSLKHIRWLRSQIAHEVNTTG--ISTYDDIEFIQKFYNQIFASTDPISQLERLg...............kyNQTSSFKKSVQDIEYRny................ynEKTFNVDHADIHISTKSENKKGSK.KKIIAALVIITIMIMFILIS--ky............................................
R6Q7Q8_9FIRM/1-159                  ....................MSFIESYKHLDKICGEMFET......QYGVSAYIEEMLNNPH-GSYLVRGWENDLKQLKHYRWIRNQIVHEPDCYEETMCEAGDDEWLDDFYERIINQTDPLAMY---..................FQATKPHPVAKSAQNH....................-EPARLQYTYSKQPSQPKHKSKKV.VRWIVFSIIVAIVLLYLVLKY-f.............................................
A0A4Z2H0T7_9TELE/10-89              .....qrgdkrrdlrnkksn--------------------......----------------------------------------------------------------------------------..................KKAEDEEGEE-----Edee..............egeEEEGGEEEGDNDKAEERNKQKKKK.KHIIIIIIIIITIIIIIIIIM-fqr...........................................
A0A834N6M0_VESGE/10-85              rlisslnvyfkndggfsrfe--------------------......----------------------------------------------------------------------------------..................-----NKKENKKRKK-....................-KKEKKKVKKKDKKRKEKKRKSTI.IIIIIIIIILIIIIIIIIII--iki...........................................
A0A1I0F9X2_9FIRM/6-184              ...................i-IFFEEYKKLENICRQMYDG......NSGVTSYIEDMEDTAISIHLNIRGWDHTLDYLKRVRHIRNQLAHD-ATFDIELSTQEDIDWVRDFYDKILHTRDPLALRYQMeq.............prkNEAKKVHDSSTKQTSQssqtm.........pinrtgQGVNEDKFTRMDNQIRHGLEKNKI.AGLAMTIFIVLIVVIVLVLLV-l.............................................
R5YY43_9FIRM/6-157                  ...................i-IFFEEYKKLDNLCKDLLGS......NQGITQYVNEMEQIPFEKSKLVESWQYDYKMLKHIRWIRNNIAHNNGDSE---CSESDVQYVKNFYQRIINRTDSFSLINVE..................IRKAEDNQASKNITNE....................---------NVDNVVSRDNSNNVF.IGITMIALIIILVIFVLMIHY-f.............................................
B1C312_9FIRM/6-147                  ....................IEFLEEYKRLDRLCQDMLST......LQGVSEYINRMELLFEQGEEFVDEWTINYKMLKHLRWLRNRIVHSVEETE---CSLKEIEMITNFYHQILIQQDPLALLYKI..................NQKIYKNKTTNQEKNK....................-------------------NIDNS.SKITMLITIVLIIIFVLFIA--gi............................................
A0A143ZRW2_9FIRM/1-158              ....................MEFMNSYKRLDNLCRDMNGI......--GITGYIEDMEIAAN-GAYYVHGWKEDYLQLKRYRHIRNRIAHENDIDEFDICSDQDEIWLRAFYQRIMTQEDPLGLY---..................YKATRLHATDKASSVQ....................ETYGDSPNVSNHSNTEKNIRKSVG.CSIFLLFSIVIIVLVAVVLRM-l.............................................
W7UWX5_RUMFL/6-171                  ...................v-DFMDLYKRTDRFIKDAYSS......SEGVSEYIRSMESCFYRGTANIKGWKSDYDNLKHIRWIRNQLAHEVS-YDSDICSESDYEWLKDFYNRLFSSTDPLGGLRTF..................-EKTVPSNKPKPPTINip................qqSPRAVYPPPQTIQQRPSVNRSSGC.LSAFIMLLILSVFLFLLLF---fml...........................................
A0A1T4M2Y2_9FIRM/1-130              ....................MEFLTVYKKLDNLCKDLLNT......DRGISTYISIMEDKSS-AAYFIQNWSDDYKALKHYRWVRNQLAHEDNVYEEDLCTEADIQWIIRFHKRILNHQDPLALYYKT..................---KRKVKTPIKPVQT....................------------------------.----------------------tiikkkdsksffqkff..............................
A0A4U7J7D2_9FIRM/1-155              ....................MSFFQQYKRLDNLCKDLFHS......DKGISTYIENMEKCGY-NAWRIVGFDTDLQMLKRYRHIRNLIAHEDDANESDYCDKSDEEWIIYFHERIIRCDDPLALYRKTiy..............apAEISKAEKETNK----....................------PSTPIPIYK-DNPNSSII.PHAVAFGFLIAIVVLFCMF---tk............................................
#=GC seq_cons                       .....................pFh-pYK+LDpLCpDhass......ppGVopYIc-MEptst.uphhl.sWspDh+tLK+hRalRNplAHpsssh-..hCotpDlpalpsFYp+IhsppDPLulh.t...................tptpptpppppp.stp................................t.ppptppppth.htlhhhhhllhllllhhhhh..h.............................................
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