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KEGG   Physeter macrocephalus (sperm whale): 102983230
Entry
102983230         CDS       T06011                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad00562  Inositol phosphate metabolism
pcad01100  Metabolic pathways
pcad01521  EGFR tyrosine kinase inhibitor resistance
pcad04012  ErbB signaling pathway
pcad04014  Ras signaling pathway
pcad04020  Calcium signaling pathway
pcad04062  Chemokine signaling pathway
pcad04064  NF-kappa B signaling pathway
pcad04066  HIF-1 signaling pathway
pcad04070  Phosphatidylinositol signaling system
pcad04072  Phospholipase D signaling pathway
pcad04360  Axon guidance
pcad04370  VEGF signaling pathway
pcad04380  Osteoclast differentiation
pcad04611  Platelet activation
pcad04613  Neutrophil extracellular trap formation
pcad04625  C-type lectin receptor signaling pathway
pcad04650  Natural killer cell mediated cytotoxicity
pcad04662  B cell receptor signaling pathway
pcad04664  Fc epsilon RI signaling pathway
pcad04666  Fc gamma R-mediated phagocytosis
pcad04670  Leukocyte transendothelial migration
pcad04722  Neurotrophin signaling pathway
pcad04750  Inflammatory mediator regulation of TRP channels
pcad04919  Thyroid hormone signaling pathway
pcad04933  AGE-RAGE signaling pathway in diabetic complications
pcad04935  Growth hormone synthesis, secretion and action
pcad05167  Kaposi sarcoma-associated herpesvirus infection
pcad05169  Epstein-Barr virus infection
pcad05170  Human immunodeficiency virus 1 infection
pcad05171  Coronavirus disease - COVID-19
pcad05200  Pathways in cancer
pcad05205  Proteoglycans in cancer
pcad05206  MicroRNAs in cancer
pcad05214  Glioma
pcad05223  Non-small cell lung cancer
pcad05225  Hepatocellular carcinoma
Module
pcad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102983230 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    102983230 (PLCG2)
   04064 NF-kappa B signaling pathway
    102983230 (PLCG2)
   04066 HIF-1 signaling pathway
    102983230 (PLCG2)
   04070 Phosphatidylinositol signaling system
    102983230 (PLCG2)
   04072 Phospholipase D signaling pathway
    102983230 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102983230 (PLCG2)
   04613 Neutrophil extracellular trap formation
    102983230 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    102983230 (PLCG2)
   04662 B cell receptor signaling pathway
    102983230 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    102983230 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    102983230 (PLCG2)
   04670 Leukocyte transendothelial migration
    102983230 (PLCG2)
   04062 Chemokine signaling pathway
    102983230 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    102983230 (PLCG2)
   04919 Thyroid hormone signaling pathway
    102983230 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102983230 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102983230 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    102983230 (PLCG2)
   04380 Osteoclast differentiation
    102983230 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102983230 (PLCG2)
   05206 MicroRNAs in cancer
    102983230 (PLCG2)
   05205 Proteoglycans in cancer
    102983230 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    102983230 (PLCG2)
   05214 Glioma
    102983230 (PLCG2)
   05223 Non-small cell lung cancer
    102983230 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102983230 (PLCG2)
   05171 Coronavirus disease - COVID-19
    102983230 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102983230 (PLCG2)
   05169 Epstein-Barr virus infection
    102983230 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102983230 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102983230 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcad04131]
    102983230 (PLCG2)
Enzymes [BR:pcad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102983230 (PLCG2)
Membrane trafficking [BR:pcad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102983230 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102983230 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like
Other DBs
NCBI-GeneID: 102983230
NCBI-ProteinID: XP_023980747
Ensembl: ENSPCTG00005017420
UniProt: A0A2Y9STJ9
Position
17:49571889..49744265
AA seq 1265 aa
MSTAVNVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETQQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEECCFTILYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKLILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLSHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDVQEMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FREVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEGEQPPDIAPTELHFGEKWFHKKVEKR
TSAEKLLQEYCAETGGKDGTFLVRESETYPNDYTLSFWRSGRVQHCRIRSTVEGGTLKYY
LTDNLMFTSIYALIQHYSETHLRCAEFELRLTDPVPNPSPHKSKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADGEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPNDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
LQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPEAQRKILMTLTVKVLGARHLPKPGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATFPIKGIKSGFRSVPLKNGYSEDLELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVREFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgagcaccgcggtcaatgttgacgcccttccggagtacgagaagagtcagatcaagagg
gccctggagctgggcacggtgatgacagtgttcagcttccgcaagtccaccccggagcgg
aggaccgtccaggtgatcatggagacccagcaggtggcctggagcaagacggccgataag
atcgagggcttcctggatatcatggaaataaaggaaatccgcccagggaagaactccaag
gattttgagcgtgcgaaagcagtccgccagaaggaagagtgctgcttcaccatcttgtac
ggcacccagttcgtcctcagcacgctcagcttagcagccgactctaaagaagatgcaact
aagtggctctctggcttgaagatcttacaccaggaagtgatgagcgcatccacccccacc
atcattgagagttggttgagaaagcagatttattctgtggatcaaaccagaagaaacagc
atcagcctccgagagttgaagaccatcttgcccctggtcaacttcaaagtgagcagcgcc
aagttcctcaaagataagttcgtggaaataggcgcacacaaagatgaactcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaattgattcttgacgaa
ttcaaaaaggattcctccgtgttcatcttgggcaacaccgaccggccggatgcctccgct
gttcacctgcacgacttccagaggtttctctcacatgaacagcaggagctttgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgagaaact
gccgagcccttcctgtttgtggatgagttcctcacgtacctgttttcccgggagaacagc
atttgggacgagaagtatgacgtggtggatgtgcaggaaatgaacaaccccttgtcgcat
tactggatctcctcatcacataacacgtacctcacgggtgaccagcttcggagcgagtcg
tccccggaggcctatatccgctgtctgcggatgggctgccgctgcattgagctggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacgcggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacctcgagcttcccc
gtgatcctgtccatcgaggagcactgctgcgtggagcagcagcgccacatggcccgggtg
ttcagggaggtgttcggcgacctgctgctgaccaagcccacggaggccagtgccgaccag
ctgccgtcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacatggaggacaagaaagatgaacacaagcagcagggtgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgtgccattgctgat
gccaagctgtccttcagcgatgacattgaacagactgtggaaggtgaacagcccccggat
atagcccccacggagctgcattttggggagaagtggttccacaagaaggtggagaagagg
acaagtgccgagaagctgctgcaggaatactgcgccgagacggggggcaaggatgggacc
ttcttggtgcgggagagcgagacctaccccaatgactacaccctgtccttctggcggtcg
ggccgcgtccagcactgccggatccgctccaccgtggagggcgggaccctgaagtattac
ctgactgacaacctcatgtttaccagcatctacgccctcatccagcactacagcgagacg
cacctgcgctgtgccgagttcgagctccggctcaccgacccagttcccaaccccagcccg
cacaagtcgaagccgtggtactacgatgggctgagccgtggagaagcggaggacatgctg
atgagggttccccgggatggcgccttcctgatccggaagcgggaaggtaccgactcctac
gccatcaccttcagggccaggggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cacttcgtgctgggcacctccgcctacttcgagagcctcgtggagctggtcagctactac
gagaagcacgcactctaccggaagatgagactgcgctaccccgtgacccccgagctcctg
gagcggtacaacatggaaagagatataaactccctctatgacgtcagcaggatgtatgtg
gatcccagtgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcaaagcgatgagctgagcttctgccgtggtgccctcatccacaacgtctcc
aaggagcctgggggctggtggaaaggagactacggaaccagaatccagcagtacttcccg
tccaattacgttgaagacatttcaacagctgatggagaggagctggaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatactggatctcaacacctataatgtt
gtaaaagccccacaggggaagaaccagaaacctttcgtctttatcttggagcccaagaag
cagggtgaccctccggtggagtttgccacagacaaggtggaggagctgttcgagtggttc
cagagcatccgggagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaaaccgacc
agcaagaccaaggacaacctagaaaaccccgacttccgagaaatccgctccttcgtggag
acaaaggctgacagcgtcgtcagacagaaacccaacgatctcttgaaatacaatcaaaag
ggcctgacccgcgtttaccccaagggacagcgggtggactcctccaactacgaccccttc
cgcctctggctgtgtggctcccagatggtggcactcaatttccagactccagataagtac
ctgcagatgaatcacgccctgttttccctcaacgggcggactggctacgtcctgcagccc
gagagcatgagggcggagaagtacgaccccatgccgcccgaggcgcagaggaagatcctg
atgactctgacggtcaaggttctgggggctcgtcatctccccaaacctggacgaagtatc
gcatgtccctttgtggaggtggaaatatgcggagccgaatatgacaacaacaagttcaaa
acaacagttgtgaatgacaacggcctaagccctgtttgggctccgacacaggagaaggtg
acgtttgaaatttatgacccaaacctcgcgtttctgcgctttgtggtttacgaggaagat
atgttcagcgatcccaactttctcgcgcatgccactttccccattaaaggaatcaagtca
ggatttagatctgttcctctgaagaacggctacagtgaagacctggagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggagctttactcctcctgc
cgccagctgcggaggcggcaagaagagctgaacaaccagctctttctgtacgacacacac
cagaacctgcgcaacgccaaccgggacgccctggtcagagagttcaacgtcaacgagaac
cagctgcagctgtaccaggagaagtgcaaccgcaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (14)   
   Pfam (14)   
All databases (75)   

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