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KEGG   Lemur catta (Ring-tailed lemur): 123625473
Entry
123625473         CDS       T08326                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat00562  Inositol phosphate metabolism
lcat01100  Metabolic pathways
lcat01521  EGFR tyrosine kinase inhibitor resistance
lcat04012  ErbB signaling pathway
lcat04014  Ras signaling pathway
lcat04020  Calcium signaling pathway
lcat04062  Chemokine signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04066  HIF-1 signaling pathway
lcat04070  Phosphatidylinositol signaling system
lcat04072  Phospholipase D signaling pathway
lcat04360  Axon guidance
lcat04370  VEGF signaling pathway
lcat04380  Osteoclast differentiation
lcat04611  Platelet activation
lcat04613  Neutrophil extracellular trap formation
lcat04625  C-type lectin receptor signaling pathway
lcat04650  Natural killer cell mediated cytotoxicity
lcat04662  B cell receptor signaling pathway
lcat04664  Fc epsilon RI signaling pathway
lcat04666  Fc gamma R-mediated phagocytosis
lcat04670  Leukocyte transendothelial migration
lcat04722  Neurotrophin signaling pathway
lcat04750  Inflammatory mediator regulation of TRP channels
lcat04919  Thyroid hormone signaling pathway
lcat04933  AGE-RAGE signaling pathway in diabetic complications
lcat04935  Growth hormone synthesis, secretion and action
lcat05167  Kaposi sarcoma-associated herpesvirus infection
lcat05169  Epstein-Barr virus infection
lcat05170  Human immunodeficiency virus 1 infection
lcat05171  Coronavirus disease - COVID-19
lcat05200  Pathways in cancer
lcat05205  Proteoglycans in cancer
lcat05206  MicroRNAs in cancer
lcat05214  Glioma
lcat05223  Non-small cell lung cancer
lcat05225  Hepatocellular carcinoma
Module
lcat_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123625473 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    123625473 (PLCG2)
   04064 NF-kappa B signaling pathway
    123625473 (PLCG2)
   04066 HIF-1 signaling pathway
    123625473 (PLCG2)
   04070 Phosphatidylinositol signaling system
    123625473 (PLCG2)
   04072 Phospholipase D signaling pathway
    123625473 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123625473 (PLCG2)
   04613 Neutrophil extracellular trap formation
    123625473 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    123625473 (PLCG2)
   04662 B cell receptor signaling pathway
    123625473 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    123625473 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    123625473 (PLCG2)
   04670 Leukocyte transendothelial migration
    123625473 (PLCG2)
   04062 Chemokine signaling pathway
    123625473 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    123625473 (PLCG2)
   04919 Thyroid hormone signaling pathway
    123625473 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    123625473 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123625473 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    123625473 (PLCG2)
   04380 Osteoclast differentiation
    123625473 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123625473 (PLCG2)
   05206 MicroRNAs in cancer
    123625473 (PLCG2)
   05205 Proteoglycans in cancer
    123625473 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    123625473 (PLCG2)
   05214 Glioma
    123625473 (PLCG2)
   05223 Non-small cell lung cancer
    123625473 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    123625473 (PLCG2)
   05171 Coronavirus disease - COVID-19
    123625473 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123625473 (PLCG2)
   05169 Epstein-Barr virus infection
    123625473 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    123625473 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123625473 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lcat04131]
    123625473 (PLCG2)
Enzymes [BR:lcat01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     123625473 (PLCG2)
Membrane trafficking [BR:lcat04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    123625473 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    123625473 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 SH3_1 C2 SH3_9 PH PH_12 SH2_1 EF-hand_PLCG1 SH3_2 PH_14 Adhesin_E GDPD
Other DBs
NCBI-GeneID: 123625473
NCBI-ProteinID: XP_045389994
Position
20:complement(12933096..13064333)
AA seq 1265 aa
MTTMVNMDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
KWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKLSSA
KFLKDKFVEMGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQNMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCVELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPLILSIEEHCSVEQQRHMAKT
FKEVFGDLLLVKPTEVSADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAVADAKLSFSDDIEQTVEEEAPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCTETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYY
LTDNLTFSSIYDLIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDML
MRIPRDGAFLIRRRDGSDSFAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVNYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIVRQKPLDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTETYHPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCSRRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgaccaccatggtcaacatggatgcccttccagaatatgagaagagtcagatcaagaga
gccctggagctggggacagtgatgaccgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaggaaatccgcccagggaagaattccaaa
gactttgagcgtgcgaaagccgtccgccagaaggaagactgctgcttcaccatcctgtac
ggcactcagttcgtcctcagcacgctcagcttggcagctgactctaaagaagatgcagtt
aagtggctctctggcttgaaaatcttacaccaagaagcgatgaatgcatccacacccacc
atgatcgagagttggctgagaaagcagatttattctgtggatcaaacgagaagaaacagc
atcagcctccgagagttgaagaccatcttgcccctggtcaacttcaaactgagcagcgcc
aagttcctcaaagataagtttgtggaaatgggtgcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaccttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcctcggtgttcatcctggggaacactgaccggcctgatgcctctgcc
gtttacctgcacgacttccagaggtttctcttacatgaacagcaggagctctgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcatcgacgacacgatgcgggaaacc
gcggagcctttcttgttcgtggacgagttcctcacctatctgttttcacgagaaaacagc
atctgggacgagaagtacgacgtggtggacatgcagaacatgaacaaccccctgtcccat
tactggatctcctcgtcccataacacgtacctcacaggggaccagctgcggagcgagtcg
tccccggaggcgtacatccgctgtctgcgcatgggctgtcgctgcgtcgagctggactgc
tgggacgggcccgacgggaagcctgtcatctaccacggctggacgcggaccaccaagatc
aagtttgatgatgttgtgcaggccatcaaagaccatgcctttgtcacctccagcttcccg
ctgatcctgtccatcgaggagcactgcagcgtggagcagcagcgccacatggccaagacc
ttcaaggaggtgttcggcgacctgctgctggtgaagcccacggaggtcagtgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgaacacaagcaacagggcgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccgtcgccgat
gccaagctgtccttcagtgacgacattgaacagactgtggaggaggaggcgccccaggat
ataccccccacagagctgcattttggggagaaatggttccacaagaaggtcgagaagagg
acgagtgccgagaagttgctgcaggaatactgcaccgagacggggggcaaggacggcacc
ttcttggtgcgggagagcgagaccttccccaacgactacaccctgtccttctggcgctcg
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccatgaagtactac
ctgactgacaacctcaccttctccagcatctacgacctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcaccgaccccgtgcccaaccccaacccc
cacgagtccaagccgtggtactacgacaggctgagccgaggagaagcagaggacatgctg
atgcgaattccccgggacggagccttcctgatccggaggcgggacggcagcgactccttc
gccatcaccttcagggctcggggcaaggtgaagcactgccgcatcaaccgggacggccgg
cacttcgtgctgggcacctccgcctattttgagagccttgtggagctcgtcaattactac
gagaagcacgccctctaccgaaagatgaggctgcgctaccccgtgacccccgagctcctg
gagcgctacaacatggaaagagatataaactccctctatgatgtcagcagaatgtacgtg
gatccgagtgaaatcaacccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcaaagcgatgagctgagcttctgccgtggcgccctcatccacaatgtctcc
aaggagcccgggggctggtggaagggagattacgggaccaggatccagcagtacttcccg
tccaattacgttgaggacatttccaccgctgacgtggaggagatggaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacacgggaaaaaccagaagccattcgtcttcatcctggagcccaagaag
cagggtgaccctccggtggagtttgccacagacagggtggaagagctctttgagtggttt
cagagcatccgggagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccaatccatcgccatcgagctctctgacctggtcgtctactgcaaaccaacc
agcaaaaccaaggataacttagaaaatcctgacttccgagaaatccgttcctttgtggag
acgaaggctgacagcatcgtcagacagaagcccctcgatctcttgaagtacaatcaaaag
ggcctgacccgtgtctaccccaagggacaaagagttgactcttcgaactacgatcccttc
cgcctctggctgtgtggctcccagatggtggcgctcaatttccagactgcagataagtac
atgcagatgaatcatgcgttgttttctctcaacgggcggacgggctatgtcctgcagccc
gagagcatgaggacagagacgtaccacccgatgccacccgagtcccagaggaaaatcctg
atgactctgactgtcaaggtcctcggtgcccgccatctccccaaacttgggcgaagtatt
gcttgtccctttgtcgaggtggaaatatgcggagccgagtatgacaacaacaagtttaag
acaacagtcgtgaatgataatggcctcagccctgtctgggctccaacacaggagaaggtg
acatttgagatttacgacccaaacctggcatttctacgctttgtggtttacgaggaagat
atgttcagtgaccccaactttcttgctcatgccacgtaccccattaaaggaatcaaatca
ggatttaggtctgtccctctgaagaatgggtacagtgaggacatcgagctcgcttccctc
ctggttttctgcgagatgcggccagtcctggagagcgaggaggaactctactcttcctgt
cgccagctgcggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaacgccaaccgggacgccctcattaaagagttcaatgtcaacgagaac
cagctccagctctaccaggagaagtgcagccggaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (15)   
   Pfam (15)   
All databases (74)   

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