Entry Name Prolactin signaling pathway
Description Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map ko04917 Prolactin signaling pathway
Ortholog table Other DBs Orthology K06279 SHC-transforming protein 1
K17447 SHC-transforming protein 2
K17448 SHC-transforming protein 3
K17449 SHC-transforming protein 4
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K09408 forkhead box protein O3
K00965 UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12 ]
K04364 growth factor receptor-bound protein 2
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04379 proto-oncogene protein c-fos
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04503 G1/S-specific cyclin-D1
K04701 cytokine inducible SH2-containing protein
K04694 suppressor of cytokine signaling 1
K04695 suppressor of cytokine signaling 2
K04696 suppressor of cytokine signaling 3
K04697 suppressor of cytokine signaling 4
K04698 suppressor of cytokine signaling 5
K04699 suppressor of cytokine signaling 6/7
K11220 signal transducer and activator of transcription 1
K04692 signal transducer and activator of transcription 3
K11223 signal transducer and activator of transcription 5A
K11224 signal transducer and activator of transcription 5B
K05473 tumor necrosis factor ligand superfamily member 11
K05147 tumor necrosis factor receptor superfamily member 11A
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K08522 glycoprotein hormones alpha chain
K04248 lutropin-choriogonadotropic hormone receptor
K08550 estrogen receptor alpha
K09444 interferon regulatory factor 1
K07593 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 2
K10151 G1/S-specific cyclin-D2
Compound C00355 3,4-Dihydroxy-L-phenylalanine
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Binart N, Bachelot A, Bouilly J
Title Impact of prolactin receptor isoforms on reproduction.
Journal Reference Authors Bachelot A, Binart N
Title Reproductive role of prolactin.
Journal Reference Authors Hennighausen L, Robinson GW
Title Information networks in the mammary gland.
Journal Reference Authors Bouilly J, Sonigo C, Auffret J, Gibori G, Binart N
Title Prolactin signaling mechanisms in ovary.
Journal Reference Authors Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ
Title Prolactin regulation of mammary gland development.
Journal Reference Authors Frasor J, Gibori G
Title Prolactin regulation of estrogen receptor expression.
Journal Reference Authors Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA
Title Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Journal Reference Authors Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL
Title Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.
Journal Reference Authors Grattan DR, Kokay IC
Title Prolactin: a pleiotropic neuroendocrine hormone.
Journal Reference Authors Yu-Lee LY, Luo G, Book ML, Morris SM
Title Lactogenic hormone signal transduction.
Journal Reference Authors Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ
Title Tissue-specific induction of SOCS gene expression by PRL.
Journal Reference Authors Halperin J, Devi SY, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman TG, Leslie ND, Le J, Binart N, Gibori G
Title Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Journal Reference Authors Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Title The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Journal Reference Authors Oakes SR, Hilton HN, Ormandy CJ
Title The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
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