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KEGG   Homo sapiens (human): 2782
Entry
2782              CDS       T01001                                 
Symbol
GNB1, HG2A, MDS, MRD42
Name
(RefSeq) G protein subunit beta 1
  KO
K04536  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04062  Chemokine signaling pathway
hsa04081  Hormone signaling
hsa04151  PI3K-Akt signaling pathway
hsa04371  Apelin signaling pathway
hsa04713  Circadian entrainment
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04744  Phototransduction
hsa04926  Relaxin signaling pathway
hsa05032  Morphine addiction
hsa05034  Alcoholism
hsa05163  Human cytomegalovirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
  Element
N00152  CXCR-GNB/G-ERK signaling pathway
N00153  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00178  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00408  LPAR-GNB/G-Rho signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00413  CXCR4-GNB/G-PLCB-PKC signaling pathway
N00428  CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
N01657  GPCR-PI3K signaling pathway
N01746  CCR/CXCR-GNB/G-PI3K signaling pathway
N01769  CCR5-GNB/G-PLCB/G signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01771  CXCR4-GNB/G signaling pathway
Disease
H00773  Autosomal dominant intellectual developmental disorder
H01481  Myelodysplastic syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2782 (GNB1)
   04151 PI3K-Akt signaling pathway
    2782 (GNB1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    2782 (GNB1)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2782 (GNB1)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    2782 (GNB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    2782 (GNB1)
   04727 GABAergic synapse
    2782 (GNB1)
   04725 Cholinergic synapse
    2782 (GNB1)
   04728 Dopaminergic synapse
    2782 (GNB1)
   04726 Serotonergic synapse
    2782 (GNB1)
   04723 Retrograde endocannabinoid signaling
    2782 (GNB1)
  09157 Sensory system
   04740 Olfactory transduction
    2782 (GNB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2782 (GNB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2782 (GNB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    2782 (GNB1)
   05163 Human cytomegalovirus infection
    2782 (GNB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2782 (GNB1)
  09165 Substance dependence
   05032 Morphine addiction
    2782 (GNB1)
   05034 Alcoholism
    2782 (GNB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2782 (GNB1)
   04031 GTP-binding proteins [BR:hsa04031]
    2782 (GNB1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2782 (GNB1)
  Exosomal proteins of colorectal cancer cells
   2782 (GNB1)
  Exosomal proteins of melanoma cells
   2782 (GNB1)
GTP-binding proteins [BR:hsa04031]
 Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    2782 (GNB1)
SSDB
Motif
Pfam: WD40 WD40_Prp19 WD40_CDC20-Fz Beta-prop_CAF1B_HIR1 WD40_WDHD1_1st Beta-prop_EML_2 Beta-prop_TEP1_2nd EIF3I WDR55 ANAPC4_WD40 Beta-prop_WDR90_POC16_2nd Beta-prop_EML WD40_MABP1-WDR62_2nd Beta-prop_TEP1_C NBCH_WD40 Beta-prop_IFT122_1st Beta-prop_SCAP Beta-prop_WDR19_1st WD40_MABP1-WDR62_1st Beta-prop_WDR75_1st Beta-prop_RIG_2nd WDR90_beta-prop_4th Beta-prop_DCAF12 Beta-prop_SPT8 Beta-prop_Vps41 Beta-prop_IFT140_1st Beta-prop_DCAF4 Beta-prop_WDR35_TULP_N WD40_like Beta-prop_EIPR1 eIF2A WD40_RFWD3 Beta-prop_HPS5 Myc-LZ Cytochrom_D1 DUF4407 CaM_bind
Other DBs
NCBI-GeneID: 2782
NCBI-ProteinID: NP_001269468
OMIM: 139380
HGNC: 4396
Ensembl: ENSG00000078369
UniProt: P62873 A0A140VJJ8
Structure
Position
1:complement(1785286..1891087)
AA seq 340 aa
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
NT seq 1023 nt   +upstreamnt  +downstreamnt
atgagtgagcttgaccagttacggcaggaggccgagcaacttaagaaccagattcgagac
gccaggaaagcatgtgcagatgcaactctctctcagatcacaaacaacatcgacccagtg
ggaagaatccaaatgcgcacgaggaggacactgcgggggcacctggccaagatctacgcc
atgcactggggcacagactccaggcttctcgtcagtgcctcgcaggatggtaaacttatc
atctgggacagctacaccaccaacaaggtccacgccatccctctgcgctcctcctgggtc
atgacctgtgcatatgccccttctgggaactatgtggcctgcggtggcctggataacatt
tgctccatttacaatctgaaaactcgtgaggggaacgtgcgcgtgagtcgtgagctggca
ggacacacaggttacctgtcctgctgccgattcctggatgacaatcagatcgtcaccagc
tctggagacaccacgtgtgccctgtgggacatcgagaccggccagcagacgaccacgttt
accggacacactggagatgtcatgagcctttctcttgctcctgacaccagactgttcgtc
tctggtgcttgtgatgcttcagccaaactctgggatgtgcgagaaggcatgtgccggcag
accttcactggccacgagtctgacatcaatgccatttgcttctttccaaatggcaatgca
tttgccactggctcagacgacgccacctgcaggctgtttgaccttcgtgctgaccaggag
ctcatgacttactcccatgacaacatcatctgcgggatcacctctgtctccttctccaag
agcgggcgcctcctccttgctgggtacgacgacttcaactgcaacgtctgggatgcactc
aaagccgaccgggcaggtgtcttggctgggcatgacaaccgcgtcagctgcctgggcgtg
actgacgatggcatggctgtggcgacagggtcctgggatagcttcctcaagatctggaac
taa

  All links  
Disease (4)   
   OMIM (4)   
Gene (21)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (69)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (66)   
DNA sequence (108)   
   RefSeq(nuc) (66)   
   GenBank (21)   
   EMBL (21)   
3D Structure (809)   
   PDB (809)   
Protein domain (37)   
   Pfam (37)   
All databases (1048)   

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