KEGG T01001: 185

Homo sapiens (human): 185

Entry

185               CDS       T01001

Symbol

AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R

Name

(RefSeq) angiotensin II receptor type 1

K04166

angiotensin II receptor type 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04081

Hormone signaling

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04270

Vascular smooth muscle contraction

hsa04371

Apelin signaling pathway

hsa04614

Renin-angiotensin system

hsa04924

Renin secretion

hsa04925

Aldosterone synthesis and secretion

hsa04927

Cortisol synthesis and secretion

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa04934

Cushing syndrome

hsa05171

Coronavirus disease - COVID-19

hsa05200

Pathways in cancer

hsa05415

Diabetic cardiomyopathy

Network

nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling

Element

N00301

Angiotensin-aldosterone signaling pathway

N01306

AngII-AT1R-NOX2 signaling pathway

N01307

SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway

N01640

GPCR-PLCB-ITPR signaling pathway

N01743

Renin-angiotensin signaling pathway

Disease

H00575

Renal tubular dysgenesis

H01633

High blood pressure

Drug target

Angiotensin II:

D00150 D02014 D11142<US>

Angiotensinamide:

D02939

Azilsartan (DG00351):

D08864<JP>

Azilsartan medoxomil (DG00351):

D08067 D08865<US>

Candesartan (DG00350):

D00522 D00626<JP/US>

Eprosartan (DG00349):

D02082 D04040

Fimasartan:

D10556

Forasartan:

D04243

Irbesartan:

D00523<JP/US>

Losartan (DG00348):

D00357<JP/US> D08146

Olmesartan (DG01544):

D05246

Olmesartan medoxomil:

D01204<JP/US>

Pratosartan:

D01922

Saprisartan potassium:

D05801

Saralasin acetate:

D04126

Sparsentan:

D11776<US>

Talfirastide:

D12942

Tasosartan:

D06010

Telmisartan:

D00627<JP/US>

Valsartan:

D00400<JP/US>

Valsartan and sacubitril:

D10226<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    185 (AGTR1)
   04022 cGMP-PKG signaling pathway
    185 (AGTR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    185 (AGTR1)
   04081 Hormone signaling
    185 (AGTR1)
09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    185 (AGTR1)
   04614 Renin-angiotensin system
    185 (AGTR1)
   04925 Aldosterone synthesis and secretion
    185 (AGTR1)
   04927 Cortisol synthesis and secretion
    185 (AGTR1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    185 (AGTR1)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    185 (AGTR1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    185 (AGTR1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    185 (AGTR1)
   04934 Cushing syndrome
    185 (AGTR1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    185 (AGTR1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    185 (AGTR1)
Membrane trafficking [BR:hsa04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    185 (AGTR1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Peptide
   Angiotensin
    185 (AGTR1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx DUF6814

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

3:148697903..148743003

AA seq 359 aa
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

NT seq 1080 nt +upstreamnt +downstreamnt
atgattctcaactcttctactgaagatggtattaaaagaatccaagatgattgtcccaaa
gctggaaggcataattacatatttgtcatgattcctactttatacagtatcatctttgtg
gtgggaatatttggaaacagcttggtggtgatagtcatttacttttatatgaagctgaag
actgtggccagtgtttttcttttgaatttagcactggctgacttatgctttttactgact
ttgccactatgggctgtctacacagctatggaataccgctggccctttggcaattaccta
tgtaagattgcttcagccagcgtcagtttcaacctgtacgctagtgtgtttctactcacg
tgtctcagcattgatcgatacctggctattgttcacccaatgaagtcccgccttcgacgc
acaatgcttgtagccaaagtcacctgcatcatcatttggctgctggcaggcttggccagt
ttgccagctataatccatcgaaatgtatttttcattgagaacaccaatattacagtttgt
gctttccattatgagtcccaaaattcaaccctcccgatagggctgggcctgaccaaaaat
atactgggtttcctgtttccttttctgatcattcttacaagttatactcttatttggaag
gccctaaagaaggcttatgaaattcagaagaacaaaccaagaaatgatgatatttttaag
ataattatggcaattgtgcttttctttttcttttcctggattccccaccaaatattcact
tttctggatgtattgattcaactaggcatcatacgtgactgtagaattgcagatattgtg
gacacggccatgcctatcaccatttgtatagcttattttaacaattgcctgaatcctctt
ttttatggctttctggggaaaaaatttaaaagatattttctccagcttctaaaatatatt
cccccaaaagccaaatcccactcaaacctttcaacaaaaatgagcacgctttcctaccgc
ccctcagataatgtaagctcatccaccaagaagcctgcaccatgttttgaggttgagtga

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